Results 21 to 30 of about 60,986 (304)
OncoImmunology, 2012 During the last two decades, several approaches for the activation of the immune system against cancer have been developed. These include rather unselective maneuvers such as the systemic administration of immunostimulatory agents (e.g., interleukin-2) as well as targeted interventions, encompassing highly specific monoclonal antibodies, vaccines and ...
Jérôme Galon +8 more
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Anti-telomerase T cells adoptive transfer
Aging, 2017 Commentary on the application of TERT-specific T cell adoptive cell therapy for cancer ...
De Sanctis, Francesco +2 more
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ADOPTIVE CELL THERAPY: CURRENT ADVANCES
Южно-Российский онкологический журнал, 2020 The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT).
T. V. Shamova +3 more
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Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Journal for ImmunoTherapy of Cancer, 2020 Background Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human
Nathalie Labarrière +17 more
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Journal of Hematology & Oncology, 2019 Background Allogeneic hematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality.
Theresa Kaeuferle +4 more
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Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors. [PDF]
PLoS ONE, 2012 Adoptive T cell therapy has proven to be beneficial in a number of tumor systems by targeting the relevant tumor antigen. The tumor antigen targeted in our model is Mammaglobin-A, expressed by approximately 80% of human breast tumors.
Nadine M Lerret +3 more
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Is there a future for adoptive cell transfer in melanoma patients? [PDF]
Oncoimmunology, 2013 The adoptive transfer of tumor-infiltrating lymphocytes (TILs) can yield durable responses in patients affected by metastatic melanoma. In particular, we have recently reported an 80% 3 year survival rate among patients who responded to this immunotherapeutic regimen.
Besser MJ.
europepmc +5 more sources
Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. [PDF]
PLoS ONE, 2018 Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients.
Folashade Otegbeye +6 more
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TARGETING TUMOURS BY ADOPTIVE TRANSFER OF IMMUNE CELLS [PDF]
Clinical and Experimental Pharmacology and Physiology, 2006 1. Surgery, radiotherapy and chemotherapy are the most widely used and well-established modalities for treating malignant diseases. Surgery is used to excise solid tumours and radiotherapy/chemotherapy are used for the treatment of liquid tumours and for solid tumours where there is a risk of micrometastases.
Paul A. MacAry, Xihu Dai, CT Too
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Adoptive cell transfer therapy for hepatocellular carcinoma [PDF]
Frontiers of Medicine, 2019 Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed.
Ding Wei +6 more
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