Results 21 to 30 of about 109,574 (350)

Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Is Transfer Dose-Dependent. [PDF]

PLoS ONE, 2016
In this study, we compared two lines of transgenic CD8+ T cells specific for the same KdM282-90 epitope of respiratory syncytial virus in the CB6F1 hybrid mouse model. Here we found that these two transgenic lines had similar in vivo abilities to control
Kaitlyn M Morabito, Noam Erez, Barney S Graham, Tracy J Ruckwardt   +3 more
doaj   +1 more source

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Assenmacher, Mario, Billingham, Lucinda, Chakraverty, Ronjon, Cobbold, Mark, Craddock, Charles, Crawley, Charles, Goldman, John, Khan, Naeem, Mahendra, Premini, McDonald, Dorothy, Moss, Paul A. H., Olavarria, Eduardo, Osman, Husam, Pourgheysari, Batoul, Steward, Colin, Tauro, Sudhir   +15 more
core   +6 more sources

Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HBV Replication through Production of IFN-γ and TNF-⍺

iScience, 2020
Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate into
Mohammad Haque, Fengyang Lei, Xiaofang Xiong, Yijie Ren, Anil Kumar, Jugal Kishore Das, Xingcong Ren, Deyu Fang, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song   +10 more
doaj   +1 more source

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
A Abe, A Duguet, A Hoshino, A Vazquez-Tello, A Vazquez-Tello, AG Besnard, AG Besnard, AI Caceres, AJ Coyle, AR Brasier, AR Sousa, AS Saffar, AT Hastie, B Korkmaz, Benjamin T. Suratt, BJ Canning, C Sutton, C Taube, D Stejskal, Daniel J. Weiss, DB Corry, DC Newcomb, DC Newcomb, DC Newcomb, DH Broide, E Goleva, F Kirstein, GJ Zijlstra, H Fujie, H Koga, H Wakashin, Hong Wei Chu, I Tillie-Leblond, J Agbetile, J Chang, J Seok, J Sunyer, J Zhao, JB Cowland, Jennifer L. Ather, JH Bates, JH Lee, JL Ather, JL Ather, John F. Alcorn, JR Karlsen, JV Fahy, K Raemdonck, K Yang, L McKinley, LA Cooney, Laura Hoyt, Lennart K. A. Lundblad, LJ Akinbami, LK Lundblad, LK Lundblad, LK Lundblad, LL Reber, M Bevelander, M Kawaguchi, M Kudo, M Leppkes, M Suzukawa, MA Willart, Matthew E. Poynter, ME Poynter, ME Poynter, ME Poynter, MH Brutsche, MH Shaw, MW Kinyanjui, N Schmitz, PA Wark, PL Delamater, PS Foster, PW Hellings, Q Wang, R He, RA Martin, Rebecca A. Martin, Rebecca Daggett, RH Wilson, S Ano, S Dragon, S Ferretti, S Haak, S Lajoie, S Molet, S Schnyder-Candrian, S Suzuki, S Wenzel, SJ Ballantyne, SM Hu, SP Chapoval, SR Hodgkins, T Li, VJ Johnson, W Al-Ramli, WP Arend, WW Lee, X Yao, XY Chi, Y Chung, Y Liu, Y Takenoue, Y Zhao, YH Wang   +106 more
core   +3 more sources

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy [PDF]

, 2020
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly ...
Adair, Jennifer E., DeBerg, Hannah A., Enstrom, Mark R., Gersuk, Vivian, Gottardo, Raphaël, Hanafi, Laïla-Aïcha, Hawkins, Reed, Kiem, Hans-Peter, Linsley, Peter S., Maloney, David G., Pande, Dnyanada, Riddell, Stanley R., Sheih, Alyssa, Turtle, Cameron J., Voillet, Valentin, Wohlfahrt, Martin E., Yajima, Masanao   +16 more
core   +1 more source

Adoptive cell transfer therapy for hepatocellular carcinoma [PDF]

Frontiers of Medicine, 2019
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed.
Renyu, Zhang, Zhao, Zhang, Zekun, Liu, Ding, Wei, Xiaodong, Wu, Huijie, Bian, Zhinan, Chen   +6 more
openaire   +2 more sources

MAIT Cell Adoptive Transfer v1 [PDF]

, 2020
This is part 3.2 of the "Study of MAIT Cell Activation in Viral Infections In Vivo" collection of protocols. Collection Abstract: MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR), which recognizes microbially derived small intermediate molecules from the riboflavin ...
Timothy S C Hinks, Bonnie van Wilgenburg, Huimeng Wang, Liyen Loh, Marios Koutsakos, Katherine Kedzierska, Alexandra J. Corbett, Zhenjun Chen   +7 more
openaire   +1 more source

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]

, 2015
Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace, Alastair Watson, Anika Fischer, Atreya, Babyatsky, Baumgart, Canavan, Caroline Voskens, Christoph Becker, Clemens Neufert, Danese, Desreumaux, Dustin, Egawa, Fantini, Feagan, Fuss, Gerlach, Gerold Schuler, Ghosh, Haddad, Hamann, Hesterberg, Hoshino, Imke Atreya, Jovani, Kanai, Kempster, Kim, Ley, Li, Macdonald, Markus F Neurath, Matsuzaki, Maul, Neurath, Neurath, Nguyen, Nourshargh, Oki, Papadakis, Picarella, Podolsky, Pryde, Raja Atreya, Rocío López-Posadas, Rott, Rutgeerts, Sandborn, Sandborn, Sebastian Zundler, Shultz, Simon Hirschmann, Strober, Thomas, Tidswell, Timo Rath, Van Assche, Vermeire, Villablanca, Wang, Weninger, Wirtz, Wyant, Wyant   +64 more
core   +1 more source

Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12 [PDF]

, 2011
Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours.
Alaniz, Almand, Appay, Barajas, Bell, Beyer, Bluestone, Brodsky, Bronte, Caruso, Catalina Atorrasagasti, Clark, Colombo, Colvin, Croci, Curiel, Dieckmann, Elkord, Ferlay, Flavia Piccioni, Gabrilovich, Gabrilovich, Ghiringhelli, Ghiringhelli, Gomez, Guillermo Mazzolini, Haigh, Huang, Jaime A. Espinoza, Jorge B. Aquino, Juan Bayo, Kerkar, Ko, Larmonier, Laura Alaniz, Leonard, Lorenz, Malvicini, Manuel Gidekel, Mariana Garcia, Mariana Ingolotti, Mariana Malvicini, Matar, Mazzolini, Mazzolini, Mazzolini, Medina-Echeverz, Melero, Nestle, O. Graciela Scharovsky, Onishi, Ormandy, Pablo Matar, Proietti, Putzer, Rabinovich, Sakaguchi, Sangro, Shapira, Spaapen, Suzuki, Takahashi, Tang, Thornton, Trinchieri, Vignali, Yokoyama, Zou, Zou, Zwirner   +69 more
core   +1 more source

ADOPTIVE CELL THERAPY: CURRENT ADVANCES

Южно-Российский онкологический журнал, 2020
The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT).
T. V. Shamova, A. O. Sitkovskaya, L. N. Vashchenko, E. E. Kechedzhieva   +3 more
doaj   +1 more source