Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer. [PDF]
Oncotarget, 2017 Adoptive cell transfer (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs) has been successful in treating a considerable proportion of patients with metastatic melanoma.
Lee HJ +18 more
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Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors. [PDF]
Proc Natl Acad Sci U S A, 2017 Xin G +6 more
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Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Is Transfer Dose-Dependent. [PDF]
PLoS ONE, 2016 In this study, we compared two lines of transgenic CD8+ T cells specific for the same KdM282-90 epitope of respiratory syncytial virus in the CB6F1 hybrid mouse model. Here we found that these two transgenic lines had similar in vivo abilities to control
Kaitlyn M Morabito +3 more
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Metastasectomy Following Immunotherapy with Adoptive Cell Transfer for Patients with Advanced Melanoma. [PDF]
Ann Surg Oncol, 2017 BackgroundImmunotherapeutic treatment strategies including adoptive cell transfer (ACT) for metastatic melanoma are capable of mediating complete and durable responses, as well as partial responses and prolonged disease stabilization. Unfortunately, many
Klemen ND +8 more
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ADOPTIVE CELL THERAPY: CURRENT ADVANCES
Южно-Российский онкологический журнал, 2020 The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT).
T. V. Shamova +3 more
doaj +1 more source
Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Journal for ImmunoTherapy of Cancer, 2020 Background Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human
Nathalie Labarrière +17 more
doaj +1 more source
Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors. [PDF]
PLoS ONE, 2012 Adoptive T cell therapy has proven to be beneficial in a number of tumor systems by targeting the relevant tumor antigen. The tumor antigen targeted in our model is Mammaglobin-A, expressed by approximately 80% of human breast tumors.
Nadine M Lerret +3 more
doaj +1 more source
Prospectives of T-cells genetic programming in adoptive immunotherapy of malignancies
Сеченовский вестник, 2022 The article reviews the literature on adoptive T-cell therapy of malignancies. Adoptive T-cell transfer allows treatment of metastatic disease on the late stages of certain tumors.
O. L. Morozova +2 more
doaj
Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. [PDF]
PLoS ONE, 2018 Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients.
Folashade Otegbeye +6 more
doaj +1 more source
Trial Watch: Adoptive cell transfer for oncological indications. [PDF]
Oncoimmunology, 2015 One particular paradigm of anticancer immunotherapy relies on the administration of (potentially) tumor-reactive immune effector cells. Generally, these cells are obtained from autologous peripheral blood lymphocytes (PBLs) ex vivo (in the context of ...
Aranda F +13 more
europepmc +2 more sources