Results 31 to 40 of about 377,496 (294)

Adoptive cell transfer therapy for hepatocellular carcinoma

Frontiers in Medicine, 2019
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed.
Renyu Zhang, Zhao Zhang, Zekun Liu, D. Wei, Xiaodong Wu, H. Bian, Zhi-Nan Chen   +6 more
semanticscholar   +1 more source

Focus on Adoptive T Cell Transfer Trials in Melanoma

Clinical and Developmental Immunology, 2010
Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with lymphodepletion has proven to be an effective treatment for metastatic melanoma patients, with an objective response rate in 50%–70% of the patients.
Liat Hershkovitz, Jacob Schachter, Avraham J. Treves, Michal J. Besser   +3 more
doaj   +1 more source

Natural Killer Cell-Mediated Cellular Therapy of Hematological Malignancies

Clinical Hematology International, 2019
Our understanding on the mechanisms of graft versus tumor/leukemia (GvT/GvL) and graft versus host (GvH) effects has tremendously evolved within the past decades.
Ugur Sahin, Meral Beksac
doaj   +1 more source

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma.

Journal of Clinical Oncology, 2005
PURPOSE We investigated the combination of lymphodepleting chemotherapy followed by the adoptive transfer of autologous tumor reactive lymphocytes for the treatment of patients with refractory metastatic melanoma.
M. Dudley, J. Wunderlich, J. Yang, R. Sherry, S. Topalian, N. Restifo, R. Royal, U. Kammula, D. White, S. Mavroukakis, L. Rogers, Gerald J Gracia, S. Jones, David P. Mangiameli, M. M. Pelletier, J. Gea-Banacloche, M. Robinson, D. Berman, A. Filie, A. Abati, S. Rosenberg   +20 more
semanticscholar   +1 more source

Beyond the antigen receptor: editing the genome of T-cells for cancer adoptive cellular therapies

Frontiers in Immunology, 2013
Recent early-stage clinical trials evaluating the adoptive transfer of patient CD8+ T-cells re-directed with antigen receptors recognising tumours have shown very encouraging results.
Angharad eLloyd, Owen Niall Vickery, Bruno eLaugel   +2 more
doaj   +1 more source

Enhanced neointima formation following arterial injury in immune deficient Rag-1-/- mice is attenuated by adoptive transfer of CD8 T cells. [PDF]

PLoS ONE, 2011
T cells modulate neointima formation after arterial injury but the specific T cell population that is activated in response to arterial injury remains unknown.
Paul C Dimayuga, Kuang-Yuh Chyu, Jonathan Kirzner, Juliana Yano, Xiaoning Zhao, Jianchang Zhou, Prediman K Shah, Bojan Cercek   +7 more
doaj   +1 more source

VSSP-activated macrophages mediate senescence and tumor inhibition in a preclinical model of advanced prostate cancer

Cell Communication and Signaling, 2023
Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an important fraction of the patients progresses to castration-resistant prostate cancer (CRPC).
Rydell Alvarez-Arzola, Nicoló Bancaro, Ping Lai, Giuseppe Attanasio, Laura Pellegrini, Martina Troiani, Manuel Colucci, Simone Mosole, Emiliano Pasquini, Andrea Alimonti, Circe Mesa   +10 more
doaj   +1 more source

Adoptive Cell Therapy in Hepatocellular Carcinoma: Biological Rationale and First Results in Early Phase Clinical Trials

Cancers, 2021
Simple Summary The mortality of hepatocellular carcinoma (HCC) is quickly increasing worldwide. Immunotherapy enables the immune defense of the organism to target liver cancer cells.
P. Rochigneux, B. Chanez, Bernadette De Rauglaudre, E. Mitry, C. Chabannon, M. Gilabert   +5 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Development of allogeneic NK cell adoptive transfer therapy in metastatic melanoma patients: in vitro preclinical optimization studies. [PDF]

PLoS ONE, 2013
Natural killer (NK) cells have long been considered as potential agents for adoptive cell therapy for solid cancer patients. Until today most studies utilized autologous NK cells and yielded disappointing results.
Michal J Besser, Tsipi Shoham, Orit Harari-Steinberg, Naama Zabari, Rona Ortenberg, Arkadi Yakirevitch, Arnon Nagler, Ron Loewenthal, Jacob Schachter, Gal Markel   +9 more
doaj   +1 more source