Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Journal for ImmunoTherapy of Cancer, 2020 Background Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human
Nathalie Labarrière +17 more
doaj +1 more source
Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives [PDF]
, 2003 While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant.
Biagi, Ettore +3 more
core +5 more sources
Journal of Hematology & Oncology, 2019 Background Allogeneic hematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality.
Theresa Kaeuferle +4 more
doaj +1 more source
Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands [PDF]
, 1992 Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a ...
Jonjic, Stipan +4 more
core +2 more sources
Anti-telomerase T cells adoptive transfer
Aging, 2017 Commentary on the application of TERT-specific T cell adoptive cell therapy for cancer ...
De Sanctis, Francesco +2 more
openaire +2 more sources
Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors. [PDF]
PLoS ONE, 2012 Adoptive T cell therapy has proven to be beneficial in a number of tumor systems by targeting the relevant tumor antigen. The tumor antigen targeted in our model is Mammaglobin-A, expressed by approximately 80% of human breast tumors.
Nadine M Lerret +3 more
doaj +1 more source
Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host [PDF]
, 1988 We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the ...
Busch, Friedrich W. +4 more
core +2 more sources
Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis
American Journal of Respiratory Cell and Molecular Biology, 2020 Patients with lymphangioleiomyomatosis (LAM) develop pulmonary cysts associated with neoplastic, smooth muscle-like cells that feature neuroendocrine cell markers. The disease preferentially affects premenopausal women. Existing therapeutics do not cure LAM.
Fei Han +10 more
openaire +3 more sources
Reenergized Adoptive Cell Transfer Immunotherapy
The FASEB Journal, 2018 Immunotherapy, in treating solid tumors, has seen increased efficacy due to the development of novel strategies of implementation. One innovative strategy, in development by Dr. Weiguo Cui and his colleagues, combines adoptive cell transfer (ACT) with pathogen‐based vaccine techniques in what is called Reenergized ACT (ReACT).
Carl Kaiser +7 more
openaire +1 more source
Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. [PDF]
PLoS ONE, 2018 Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients.
Folashade Otegbeye +6 more
doaj +1 more source