Results 31 to 40 of about 306,104 (338)

Adoptive Immunotherapy for Cancer or Viruses [PDF]

Annual Review of Immunology, 2014
Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy.
Michael Kalos, Bruce L. Levine, Joseph A. Fraietta, Carl H. June, Yangbing Zhao, Marcela V. Maus   +5 more
openaire   +3 more sources

Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model. [PDF]

PLoS ONE, 2012
Both adoptive immunotherapy and gene therapy hold a great promise for treatment of malignancies. However, these strategies exhibit limited anti-tumor activity, when they are used alone.
Zhi Yang, Qianzhen Zhang, Ke Xu, Juanjuan Shan, Junjie Shen, Limei Liu, Yanmin Xu, Feng Xia, Ping Bie, Xia Zhang, Youhong Cui, Xiu-Wu Bian, Cheng Qian   +12 more
doaj   +1 more source

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing

Frontiers in Immunology, 2019
CAR-NK cells may represent a valuable tool, complementary to CAR-T cells, in adoptive immunotherapy of leukemia and solid tumors. However, gene transfer to human NK cells is a challenging task, particularly with non-virus-based techniques.
Tiziano Ingegnere, Francesca Romana Mariotti, Andrea Pelosi, Concetta Quintarelli, Concetta Quintarelli, Biagio De Angelis, Nicola Tumino, Francesca Besi, Claudia Cantoni, Franco Locatelli, Paola Vacca, Lorenzo Moretta   +11 more
doaj   +1 more source

Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy

eLife, 2016
The combined-immunotherapy of adoptive cell therapy (ACT) and cyclophosphamide (CTX) is one of the most efficient treatments for melanoma patients. However, no synergistic effects of CTX and ACT on the spatio-temporal dynamics of immunocytes in vivo have
Shuhong Qi, Hui Li, Lisen Lu, Zhongyang Qi, Lei Liu, Lu Chen, Guanxin Shen, Ling Fu, Qingming Luo, Zhihong Zhang   +9 more
doaj   +1 more source

Application of Immunotherapy in Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma is one of the most common malignancies globally. It not only has a hidden onset but also progresses rapidly. Most HCC patients are already in the advanced stage of cancer when they are diagnosed, and have even lost the ...
Lele Miao, Lele Miao, Zhengchao Zhang, Zhengchao Zhang, Zhijian Ren, Zhijian Ren, Yumin Li, Yumin Li   +7 more
doaj   +1 more source

Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells.

Blood, 2019
Chimeric antigen receptor (CAR) T cells have emerged as a promising class of cell-based immunotherapy in refractory malignancies. Neurotoxicity represents a common and potentially life-threatening adverse effect of CAR T cells, and clinical experience is
P. Karschnia, P. Karschnia, J. Jordan, D. Forst, I. Arrillaga-Romany, T. Batchelor, J. Baehring, Nathan F. Clement, L. Castro, A. Herlopian, M. Maus, Michaela H. Schwaiblmair, J. Soumerai, R. Takvorian, E. Hochberg, J. Barnes, J. Abramson, M. Frigault, J. Dietrich   +18 more
semanticscholar   +1 more source

A 9L Gliosarcoma Transplantation Model for Studying Adoptive Immunotherapy into the Brains of Conscious Rats

Cell Transplantation, 1992
A rat model for brain tumor immunotherapy is described that closely mimics the type of treatment that could be administered to humans. It involves surgical implantation of a permanent cannula in the brain, through which tumor cells and various effector ...
Monika Fleshner, Linda R. Watkins, Joan M. Redd, Carol A Kruse, Donald Bellgrau   +4 more
doaj   +1 more source

Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy

Frontiers in Immunology
Invariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
doaj   +1 more source

The State of Cellular Adoptive Immunotherapy for Neuroblastoma and Other Pediatric Solid Tumors

Frontiers in Immunology, 2017
Research on adult cancer immunotherapy is proceeding at a rapid pace resulting in an impressive success rate exemplified by a few high profile cases. However, this momentum is not readily extended to pediatric immunotherapy, and it is not for lack of ...
Thanh-Phuong Le, To-Ha Thai
doaj   +1 more source

Chimeric Antigen Receptor T Cell Therapy in Hematology

Turkish Journal of Hematology, 2015
It is well demonstrated that the immune system can control and eliminate cancer cells. Immune-mediated elimination of tumor cells has been discovered and is the basis of both cancer vaccines and cellular therapies including hematopoietic stem cell ...
Pınar Ataca, Önder Arslan
doaj   +1 more source