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Impact of Prior Treatment on the Efficacy of Adoptive Transfer of Tumor-Infiltrating Lymphocytes in Patients with Metastatic Melanoma. [PDF]
Purpose: Adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes (TIL) can mediate durable responses in patients with metastatic melanoma.
Seitter SJ+14 more
europepmc +2 more sources
Adoptive Transfer of Memory B Cells [PDF]
The adoptive transfer of antigen-specific B cells into mice that cannot recognize that specific antigen has two main advantages. The first is determining exactly when the B cells were transferred and exposed to antigen.
Griselda Zuccarino-Catania+1 more
doaj +4 more sources
Adoptive Tolerance; Transfer of the Tolerant State [PDF]
Summary Lymphoid cells from tolerant mice can be successfully transferred to a new environment without affecting their tolerant behavior. In such transfer, both the original host and donor cells are transferred, with the establishment of a chimeric state in the irradiated recipients.
Bertie F. Argyris
openalex +3 more sources
Background Allogeneic hematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality.
Theresa Kaeuferle+4 more
doaj +2 more sources
Is It Feasible to Use CMV-Specific T-Cell Adoptive Transfer as Treatment Against Infection in SOT Recipients? [PDF]
During the last decade, many studies have demonstrated the role of CMV specific T-cell immune response on controlling CMV replication and dissemination. In fact, it is well established that transplanted patients lacking CMV-specific T-cell immunity have ...
Estéfani García-Ríos+3 more
doaj +2 more sources
Adoptive Cellular Transfer Immunotherapies for Cancer
Patients with cancer require efficient treatment approaches as the mortality rate due to their disease is high. Conventional therapies, like chemotherapy and radiation, have severe side effects.
Panagiotis Parsonidis+1 more
doaj +3 more sources
Adoptive Transfer of Immunologic Tolerance into Normal Mice [PDF]
Abstract Preimmunization tolerance induced by injecting mice with moderate quantities of purified protein antigens in saline and preventing later attempted induction of delayed hypersensitivity by injection of these antigens in Freund's adjuvant could be broken by adoptive transfer of spleen cells from sensitized donors but not by cells ...
Alfred J. Crowle, Chengping Hu
openalex +4 more sources
Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury
ObjectiveThe aim of this study is to clarify the role of regulatory T cell (Treg) in triptolide (TP)-induced hepatotoxicity. MethodsFemale C57BL/6 mice received either adoptive transfer of Tregs or depletion of Tregs, then underwent TP administration and
Xinzhi eWang+3 more
doaj +2 more sources
Focus on Adoptive T Cell Transfer Trials in Melanoma [PDF]
Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with lymphodepletion has proven to be an effective treatment for metastatic melanoma patients, with an objective response rate in 50%–70% of the patients.
Liat Hershkovitz+3 more
doaj +4 more sources
Adoptive Transfer of Isolated Bone Marrow Neutrophils [PDF]
Adoptive transfer experiments of specific cell populations are widely used methods to assess the role of the injected population on an ongoing process.
Jimena Boari, Eva Rodríguez
doaj +5 more sources