Results 21 to 30 of about 3,239,660 (397)

Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model. [PDF]

PLoS ONE, 2015
Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used the non-viral piggyBac transposon system to gene modify human T cells for potential immunotherapy.
Daniel L Galvan, Richard T O'Neil, Aaron E Foster, Leslie Huye, Adham Bear, Cliona M Rooney, Matthew H Wilson   +6 more
doaj   +1 more source

Adoptive transfer of acute lung injury [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000
In this study, we describe a novel adoptive transfer protocol to study acute lung injury in the rat. We show that bronchoalveolar lavage (BAL) cells isolated from rats 5 h after intratracheal administration of lipopolysaccharide (LPS) induce a lung injury when transferred to normal control recipient rats.
Tracey L. Baird, John A. Corbett, Michael A. Moxley   +2 more
openaire   +3 more sources

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor–transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

Journal of immunotherapy, 2019
A deletion variant of epidermal growth factor receptor (EGFRvIII) is a known driver mutation in a subset of primary and secondary glioblastoma multiforme.
Stephanie L. Goff, R. Morgan, J. Yang, R. Sherry, P. Robbins, N. Restifo, S. Feldman, Yong-Chen Lu, Lily Lu, Zhili Zheng, L. Xi, Monica Epstein, Lori S. McIntyre, Parisa Malekzadeh, M. Raffeld, H. Fine, S. Rosenberg   +16 more
semanticscholar   +1 more source

Role of contrasuppression in the adoptive transfer of immunity. [PDF]

The Journal of experimental medicine, 1983
The data presented in this paper show that the population of cells that adoptively transfer contact hypersensitivity are Lyt-1+ 2-, I-J- and nonadherent to V. villosa lectin. However, the adoptive transfer of immunity by this population of cells is successful only when the recipient has been treated in such a way as to impair the host immunosuppression
Iverson, M, Ptak, W, Green, D R, Gershon, R K   +3 more
openaire   +3 more sources

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA–peptide tetramers [PDF]

, 2005
Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the early posttransplant period, and reactivation of cytomegalovirus (CMV) remains a significant ...
Assenmacher, Mario, Billingham, Lucinda, Chakraverty, Ronjon, Cobbold, Mark, Craddock, Charles, Crawley, Charles, Goldman, John, Khan, Naeem, Mahendra, Premini, McDonald, Dorothy, Moss, Paul A. H., Olavarria, Eduardo, Osman, Husam, Pourgheysari, Batoul, Steward, Colin, Tauro, Sudhir   +15 more
core   +5 more sources

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy [PDF]

, 2020
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly ...
Adair, Jennifer E., DeBerg, Hannah A., Enstrom, Mark R., Gersuk, Vivian, Gottardo, Raphaël, Hanafi, Laïla-Aïcha, Hawkins, Reed, Kiem, Hans-Peter, Linsley, Peter S., Maloney, David G., Pande, Dnyanada, Riddell, Stanley R., Sheih, Alyssa, Turtle, Cameron J., Voillet, Valentin, Wohlfahrt, Martin E., Yajima, Masanao   +16 more
core   +1 more source

Immune cell labelling and tracking: implications for adoptive cell transfer therapies

EJNMMI Radiopharmacy and Chemistry, 2021
Background The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer.
Filippo Galli, Michela Varani, Chiara Lauri, Guido Gentiloni Silveri, Livia Onofrio, Alberto Signore   +5 more
doaj   +1 more source

A phase II clinical trial of adoptive transfer of haploidentical natural killer cells for consolidation therapy of pediatric acute myeloid leukemia

Journal of Immunotherapy for Cancer, 2019
Consolidation therapies for children with intermediate- or high-risk acute myeloid leukemia (AML) are urgently needed to achieve higher cure rates while limiting therapy-related toxicities.
R. Nguyen, Huiyun Wu, S. Pounds, H. Inaba, R. Ribeiro, David L Cullins, Barbara Rooney, Teresa Bell, Norman J. Lacayo, K. Heym, B. Degar, D. Schiff, W. Janssen, B. Triplett, C. Pui, W. Leung, J. Rubnitz   +16 more
semanticscholar   +1 more source

Rank aggregation of independent genetic screen results highlights new strategies for adoptive cellular transfer therapy of cancer

Frontiers in Immunology, 2023
Efficient intratumoral infiltration of adoptively transferred cells is a significant barrier to effectively treating solid tumors with adoptive cellular transfer (ACT) therapies. Our recent forward genetic, whole-genome screen identified T cell-intrinsic
Vianca V. Vianzon, Rylee M. Hanson, Ishita Garg, Gwenyth J. Joseph, Laura M. Rogers   +4 more
doaj   +1 more source