Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]
, 1996 We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA +6 more
core
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4. [PDF]
, 2017 While it is recognized that aquaporin-4 (AQP4)-specific T cells and antibodies participate in the pathogenesis of neuromyelitis optica (NMO), a human central nervous system (CNS) autoimmune demyelinating disease, creation of an AQP4-targeted model with ...
Cruz-Herranz, Andrés +7 more
core +1 more source
iScience, 2020 Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate into
Mohammad Haque +10 more
doaj
Frontiers in Immunology, 2018 CPT-11 is a first-line chemotherapeutic agent for the treatment of colorectal cancer in clinic. Previous studies including ours have demonstrated that CPT-11 is, however, toxic to the intestinal epithelium and resident peritoneal macrophages.
Wen-Jing Bai +8 more
doaj +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]
, 1990 Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Jonjic, Stipan +4 more
core
Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12 [PDF]
, 2011 Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours.
Alaniz +69 more
core +1 more source
The Golden Retriever Rule: Alaska’s Identity Privilege for Animal Adoption Agencies and for Adoptive Animal Owners [PDF]
, 2004 Sedan 1900-talets mitt har användandet av tegelkonstruktioner i bostadsbyggandet minskat kraftigt; materialet har under modernismen upplevts otidsenligt och byggnadssättet har ansetts ineffektivt.
Tiemessen, John J., Weiner, Jason A.
core +2 more sources
Adoptive Transfer of Monocytes Sorted from Bone Marrow
Bio-Protocol, 2019 Inflammatory Ly6Chi monocytes can give rise to distinct mononuclear myeloid cells in the tumor microenvironment, such as monocytic myeloid-derived suppressor cells (Mo-MDSC), immature macrophages, M2-like tumor-associated macrophages (TAMs), M1-like TAMs
Damya Laoui +4 more
doaj +1 more source
Successful adoptive transfer and in vivo expansion of haploidentical γδ T cells
Journal of Translational Medicine, 2014 BackgroundThe primary aim of this pilot study was to determine the feasibility and safety of an adoptive transfer and in vivo expansion of human haploidentical γδ T lymphocytes.MethodsPatients with advanced haematological malignancies who are not ...
M. Wilhelm +6 more
semanticscholar +1 more source