Results 161 to 170 of about 4,726 (204)

Purification and Characterization of ADP-Ribosyl Cyclase from Euglena gracilis

Journal of Biochemistry, 1999
ADP-ribosyl cyclase, which catalyzes the conversion from NAD+ to cyclic adenosine diphosphoribose (cADPR), is proposed to participate in cell cycle regulation in Euglena gracilis. This enzyme, which was found as a membrane-bound protein, was purified almost the homogeneity after solubilization with deoxycholate, and found to be a monomeric protein with
W, Masuda, S, Takenaka, S, Tsuyama, H, Inui, K, Miyatake, Y, Nakano   +5 more
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GTP stabilization of adenylate cyclase activated and ADP-ribosylated by choleragen

Biochemical and Biophysical Research Communications, 1981
Abstract Choleragen activates adenylate cyclase in human skin fibroblasts by catalyzing the ADP-ribosylation of the 42,000 and 47,000 dalton guanyl nucleotide-binding regulatory components (G) of adenylate cyclase. The ADP-ribose linkage to 42,000 and 47,000 dalton proteins was stable at 30°C for 1 h with or without GTP, whereas GTP was required to ...
S, Nakaya, P A, Watkins, A J, Bitonti, L M, Hjelmeland, J, Moss, M, Vaughan   +5 more
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ADP-ribosyl cyclase couples to cyclic AMP signaling in the cardiomyocytes

Biochemical and Biophysical Research Communications, 2005
ADP-ribosyl cyclase (ADPR-cyclase) produces a Ca(2+)-mobilizing second messenger cyclic ADP-ribose (cADPR) from beta-NAD(+). In this study, we examined the molecular basis of which beta-adrenergic receptor (betaAR) stimulation induces cADPR formation and characterized cardiac ADPR-cyclase.
Guang-Hua, Xie, So-Young, Rah, Sang-Jin, Kim, Tae-Sik, Nam, Ki-Chan, Ha, Soo-Wan, Chae, Mie-Jae, Im, Uh-Hyun, Kim   +7 more
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NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases

Biochemical and Biophysical Research Communications, 2006
ADP-ribosyl cyclases (ADPRCs) are present from lower Metazoa to mammals and synthesize the Ca2+-active (di)nucleotides cyclic ADP-ribose (cADPR), NAADP+, and ADP-ribose (ADPR), involved in the regulation of important cellular functions. NAADP+ can be synthesized by ADPRCs from NADP+ through a base-exchange reaction, which substitutes nicotinamide for ...
Moreschi, Iliana, Bruzzone, Santina, Melone, Luca, De Flora, Antonio, Zocchi, Elena   +4 more
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Altered Regulation of Adenylate Cyclase after Toxin-Catalyzed ADP-Ribosylation

1985
Publisher Summary This chapter presents an analysis of three types of ADP-Ribosylation, namely, ADP-ribosylation of Gs by choleragen, ADP-ribosylation of Gi by pertussis toxin, and ADP-ribosylation of transducin. The other known ADP-ribosyltransferases are bacteriophage products or bacterial toxins whose functions should probably be described as ...
M, Vaughan, J, Moss
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Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD+ glycohydrolases

Biochemical Journal, 2000
Highly purified Aplysia californica ADP-ribosyl cyclase was found to be a multifunctional enzyme. In addition to the known transformation of NAD+ into cADP-ribose this enzyme is able to catalyse the solvolysis (hydrolysis and methanolysis) of cADP-ribose.
C, Cakir-Kiefer, H, Muller-Steffner, F, Schuber   +2 more
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ADP-ribosylation of brain synaptosomal proteins correlates with adenylate cyclase activation

Biochemical and Biophysical Research Communications, 1982
Abstract ADP-ribosylation of the adenylate cyclase G F regulatory subunit by cholera toxin is a major tool for the study of this enzyme. Investigation of the brain enzyme has been hampered up to now by the failure to demonstrate cholera toxin-dependent ADP-ribosylation of membrane-bound proteins.
G, Berthillier, J, d'Alayer, A, Monneron
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Catalytic properties of the retinal rod outer segment disk ADP-ribosyl cyclase

Visual Neuroscience, 2011
AbstractCyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role. ROS ADP-ribosyl cyclase (ADPR-cyclase) was localized in the membrane fraction.
A. Fabiano, I. Panfoli, D. Calzia, M. Bruschi, S. Ravera, A. Bachi, A. Cattaneo, A. Morelli, G. Candiano.   +8 more
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A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis

Nature Cell Biology, 1999
Nucleoplasmic calcium ions (Ca2+) influence nuclear functions as critical as gene transcription, apoptosis, DNA repair, topoisomerase activation and polymerase unfolding. Although both inositol trisphosphate receptors and ryanodine receptors, types of Ca2+ channel, are present in the nuclear membrane, their role in the homeostasis of nuclear Ca2 ...
O A, Adebanjo, H K, Anandatheerthavarada, A P, Koval, B S, Moonga, G, Biswas, L, Sun, B R, Sodam, P J, Bevis, C L, Huang, S, Epstein, F A, Lai, N G, Avadhani, M, Zaidi   +12 more
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Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase

Nature, 1986
Although cholera toxin induces a marked stimulation of adenylate cyclase activity in rat adipocyte plasma membranes, the holotoxin induces only a slight increase of cyclic AMP accumulation in intact cells. A similar apparent anomaly is seen with pertussis toxin, which has been shown to inhibit the Gi subunit of adenylate cyclase, and has a greater ...
C, Jacquemin, H, Thibout, B, Lambert, C, Correze   +3 more
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