Results 161 to 170 of about 4,754 (181)

NAADP+ synthesis from cADPRP and nicotinic acid by ADP-ribosyl cyclases

Biochemical and Biophysical Research Communications, 2006
ADP-ribosyl cyclases (ADPRCs) are present from lower Metazoa to mammals and synthesize the Ca2+-active (di)nucleotides cyclic ADP-ribose (cADPR), NAADP+, and ADP-ribose (ADPR), involved in the regulation of important cellular functions. NAADP+ can be synthesized by ADPRCs from NADP+ through a base-exchange reaction, which substitutes nicotinamide for ...
Moreschi, Iliana, Bruzzone, Santina, Melone, Luca, De Flora, Antonio, Zocchi, Elena   +4 more
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Altered Regulation of Adenylate Cyclase after Toxin-Catalyzed ADP-Ribosylation

1985
Publisher Summary This chapter presents an analysis of three types of ADP-Ribosylation, namely, ADP-ribosylation of Gs by choleragen, ADP-ribosylation of Gi by pertussis toxin, and ADP-ribosylation of transducin. The other known ADP-ribosyltransferases are bacteriophage products or bacterial toxins whose functions should probably be described as ...
M, Vaughan, J, Moss
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Unifying mechanism for Aplysia ADP-ribosyl cyclase and CD38/NAD+ glycohydrolases

Biochemical Journal, 2000
Highly purified Aplysia californica ADP-ribosyl cyclase was found to be a multifunctional enzyme. In addition to the known transformation of NAD+ into cADP-ribose this enzyme is able to catalyse the solvolysis (hydrolysis and methanolysis) of cADP-ribose.
C, Cakir-Kiefer, H, Muller-Steffner, F, Schuber   +2 more
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ADP-ribosylation of brain synaptosomal proteins correlates with adenylate cyclase activation

Biochemical and Biophysical Research Communications, 1982
Abstract ADP-ribosylation of the adenylate cyclase G F regulatory subunit by cholera toxin is a major tool for the study of this enzyme. Investigation of the brain enzyme has been hampered up to now by the failure to demonstrate cholera toxin-dependent ADP-ribosylation of membrane-bound proteins.
G, Berthillier, J, d'Alayer, A, Monneron
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Catalytic properties of the retinal rod outer segment disk ADP-ribosyl cyclase

Visual Neuroscience, 2011
AbstractCyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role. ROS ADP-ribosyl cyclase (ADPR-cyclase) was localized in the membrane fraction.
A. Fabiano, I. Panfoli, D. Calzia, M. Bruschi, S. Ravera, A. Bachi, A. Cattaneo, A. Morelli, G. Candiano.   +8 more
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A new function for CD38/ADP-ribosyl cyclase in nuclear Ca2+ homeostasis

Nature Cell Biology, 1999
Nucleoplasmic calcium ions (Ca2+) influence nuclear functions as critical as gene transcription, apoptosis, DNA repair, topoisomerase activation and polymerase unfolding. Although both inositol trisphosphate receptors and ryanodine receptors, types of Ca2+ channel, are present in the nuclear membrane, their role in the homeostasis of nuclear Ca2 ...
O A, Adebanjo, H K, Anandatheerthavarada, A P, Koval, B S, Moonga, G, Biswas, L, Sun, B R, Sodam, P J, Bevis, C L, Huang, S, Epstein, F A, Lai, N G, Avadhani, M, Zaidi   +12 more
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Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase

Nature, 1986
Although cholera toxin induces a marked stimulation of adenylate cyclase activity in rat adipocyte plasma membranes, the holotoxin induces only a slight increase of cyclic AMP accumulation in intact cells. A similar apparent anomaly is seen with pertussis toxin, which has been shown to inhibit the Gi subunit of adenylate cyclase, and has a greater ...
C, Jacquemin, H, Thibout, B, Lambert, C, Correze   +3 more
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Assay for ADP-Ribosyl Cyclase by Reverse-Phase High-Performance Liquid Chromatography

Analytical Biochemistry, 2001
Cyclic ADP-ribose (cADPR), a natural metabolite of beta-NAD(+), is a second messenger for Ca(2+) signaling in T cells. As a tool for purification and identification of ADP-ribosyl cyclase(s) in T cells, a sensitive and specific enzymatic assay using 1,N(6)-etheno-NAD(+) as substrate was developed.
K, Schweitzer, G W, Mayr, A H, Guse
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Mono(ADP-ribosyl)ation of Gi by eukaryotic cysteine-specific mono(ADP-ribosyl)transferase attenuates inhibition of adenylate cyclase by epinephrine

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
Eukaryotic cysteine-specific mono(ADP-ribosyl)transferase, named ADP-ribosyltransferase C (Tanuma, S., Kawashima, K. and Endo, H. (1988) J. Biol. Chem. 263, 5485-5489), attenuates inhibition of adenylate cyclase in human platelet membranes by epinephrine. This attenuation appeared to result from mono(ADP-ribosyl)ation by ADP-ribosyltransferase C of the
S, Tanuma, H, Endo
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Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase

Journal of Molecular Biology, 2012
Cyclic ADP-ribose (cADPR) is a calcium messenger that can mobilize intracellular Ca²⁺ stores and activate Ca²⁺ influx to regulate a wide range of physiological processes. Aplysia cyclase is the first member of the ADP-ribosyl cyclases identified to catalyze the cyclization of NAD⁺ into cADPR.
Graeff, R, Chen, Z, Hao, Q, Kotaka, M, Lee, HC, Zhang, LH   +5 more
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