Results 171 to 180 of about 4,726 (204)

Assay for ADP-Ribosyl Cyclase by Reverse-Phase High-Performance Liquid Chromatography

Analytical Biochemistry, 2001
Cyclic ADP-ribose (cADPR), a natural metabolite of beta-NAD(+), is a second messenger for Ca(2+) signaling in T cells. As a tool for purification and identification of ADP-ribosyl cyclase(s) in T cells, a sensitive and specific enzymatic assay using 1,N(6)-etheno-NAD(+) as substrate was developed.
K, Schweitzer, G W, Mayr, A H, Guse
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Mono(ADP-ribosyl)ation of Gi by eukaryotic cysteine-specific mono(ADP-ribosyl)transferase attenuates inhibition of adenylate cyclase by epinephrine

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
Eukaryotic cysteine-specific mono(ADP-ribosyl)transferase, named ADP-ribosyltransferase C (Tanuma, S., Kawashima, K. and Endo, H. (1988) J. Biol. Chem. 263, 5485-5489), attenuates inhibition of adenylate cyclase in human platelet membranes by epinephrine. This attenuation appeared to result from mono(ADP-ribosyl)ation by ADP-ribosyltransferase C of the
S, Tanuma, H, Endo
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Structural Studies of Intermediates along the Cyclization Pathway of Aplysia ADP-Ribosyl Cyclase

Journal of Molecular Biology, 2012
Cyclic ADP-ribose (cADPR) is a calcium messenger that can mobilize intracellular Ca²⁺ stores and activate Ca²⁺ influx to regulate a wide range of physiological processes. Aplysia cyclase is the first member of the ADP-ribosyl cyclases identified to catalyze the cyclization of NAD⁺ into cADPR.
Graeff, R, Chen, Z, Hao, Q, Kotaka, M, Lee, HC, Zhang, LH   +5 more
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ADP ribosyl cyclase activity in rat parotid acinar cells.

European journal of morphology, 1999
Cyclic ADP-ribose is an intracellular compound responsible for Ca2+ release in a wide variety of cell types. It may be implicated in releasing Ca2+ from ryanodine-sensitive pools in exocrine acinar cells. A bifunctional enzyme CD38 can synthesize cADP-ribose and we have characterized its properties by applying a technique in which nicotinamide guanine ...
Looms, D.K., Nauntofte, Birgitte, Dissing, S.   +2 more
openaire   +1 more source

Cyclic ADP-ribose, the ADP-ribosyl cyclase pathway and calcium signalling

Molecular and Cellular Endocrinology, 1994
Cyclic adenosine diphosphate-ribose, an endogenous metabolite of nicotinamide adenine dinucleotide was first characterized as a potent Ca2+ mobilizing agent in sea urchin eggs. Mounting evidence points to it being an endogenous activator of Ca(2+)-induced Ca2+ release by non-skeletal muscle ryanodine receptors in several invertebrate and mammalian cell
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ADP-Ribosyl Cyclases - A Family of cADPR and NAADP Metabolizing Enzymes

2002
ADP-ribosyl cyclase cyclizes NAD to produce cyclic ADP-ribose (cADPR) and releases nicotinamide in the process [1]. It is a ubiquitous enzyme widely present in animal cells [1, 2] and has even been identified in Euglena, a protozoan [4]. The first cyclase purified was from Aplysia ovotestis [1, 5].
Hon Cheung Lee, Cyrus B. Munshi, Richard Graeff   +2 more
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Intermediates along the NAD+ cyclisation reaction pathway of ADP-ribosyl cyclase

2011
Calcium is a ubiquitous, versatile intracellular signal regulating numerous cellular processes [1]. The versatility of Ca2+ signalling emerges from the use of an extensive repertoire of signalling components known as a Ca2+ signalling toolkit that can be assembled in combinations to create signals with different spatial and temporal profiles ...
Zhang, L, Lee, HC, Graeff, R, Kotaka, M, Hao, Q   +4 more
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Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention

Ca-A Cancer Journal for Clinicians, 2017
Cynthia Morata-Tarifa, Joyce M Slingerland   +1 more
exaly  

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Ca-A Cancer Journal for Clinicians, 2020
Aaron J Grossberg, William L Hwang, Anirban Maitra   +2 more
exaly