Results 31 to 40 of about 4,363 (152)

Phenotypic Characterization of Acute Systemic and Renal Vascular Responses to Angiotensin II, Norepinephrine, and Endothelin‐1 in Mice Lacking the ADP Ribosyl Cyclase CD38

The FASEB Journal, 2008
Vasoconstriction is mediated by increases in cytosolic calcium concentration ([Ca 2+ ] i ). ADP ribosyl cyclases regulate [Ca2+] i via metabolite activation of Ca 2 ...
Tiffany L Thai, William J Arendshorst
openaire   +1 more source

Impaired learning and memory in CD38 null mutant mice [PDF]

, 2016
CD38 is an enzyme that catalyzes the formation of cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate, both of which are involved in the mobilization of Ca2+ from intracellular stores.
Jang, Eun-Hye, Kaang, Bong-Kiun, Kang, Minkyung, Kim, Jae-Ick, Kim, Sang Jeong, Kim, Somi, Kim, TaeHyun, Kim, Uh-Hyun, Lee, Bolam, Lee, Hye-Ryeon, Lee, Yong-Seok, Lim, Chae Seok, Rah, So-Young, Ryu, Hyun-Hee, Yoo, Juyoun   +14 more
core   +1 more source

Nitric oxide and synaptic function [PDF]

, 1994
The free radical gas nitric oxide (NO) is a recently identified neuronal messenger that carries out diverse signaling tasks in both the central and peripheral nervous systems.
Madison, Daniel V., Schuman, Erin M.
core   +1 more source

Integration of B-cell receptor-induced ERK1/2 phosphorylation and mutations of SF3B1 gene refines prognosis in treatment-na\uefve chronic lymphocytic leukemia [PDF]

, 2016
ADP-ribosyl Cyclase 1; Disease Progression; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Variable[no abstract ...
Ambrosetti, Achille, Cavallini, Chiara, Cesano, Alessandra, Facco, Monica, Falisi, Erika, Gaidano, Gianluca, Lovato, Ornella, Mimiola, Elda, Perbellini, Omar, Pizzolo, Giovanni, Purvis, Norman, Putta, Santosh, Romanelli, Maria Giovanna, Rossi, Davide, Scupoli, Maria T., Semenzato, Gianpietro Carlo, Trentin, Livio, Visco, Carlo   +17 more
core   +3 more sources

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Design, synthesis and biological characterization of novel inhibitors of CD38 [PDF]

, 2011
Human CD38 is a novel multi-functional protein that acts not only as an antigen for B-lymphocyte activation, but also as an enzyme catalyzing the synthesis of a Ca 2+ messenger molecule, cyclic ADP-ribose, from NAD +.
Cheung Lee, H, Dong, M, Hao, Q, Kriksunov, IA, Kwong, AKY, Lam, CMC, Leung, FP, Pu, XP, Si, YQ, Sun, SY, Yang, ZJ, Yue, J, Zhang, LH, Zhang, LR, Zhou, Y   +14 more
core   +1 more source

Cyclic ADP ribose is a novel regulator of intracellular Ca 2+ oscillations in human bone marrow mesenchymal stem cells [PDF]

, 2011
Bone marrow mesenchymal stem cells (MSCs) are a promising cell source for regenerative medicine. However, the cellular biology of these cells is not fully understood. The present study characterizes the cyclic ADP-ribose (cADPR)-mediated Ca 2+ signals in
Lau, CP, Lee, HC, Li, GR, Sun, HY, Tao, R, Tse, HF   +5 more
core   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, Volume 13, Issue 11, 23 February 2026.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Differential gene expression in the murine gastric fundus lacking interstitial cells of Cajal. [PDF]

, 2011
BACKGROUND: The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric slow waves.
Caldas, Carlos, Daigo, Yataro, Fujino, Masayuki A, Ponder, Bruce AJ, Sanders, Kenton M, Takayama, Ichiro, Ward, Sean M   +6 more
core   +1 more source

Membrane-translocating peptides and toxins: from nature to bedside [PDF]

, 2008
Today, different functional classes of bioactive peptides and toxins isolated from diverse sources of living organisms are known. In medicine, these polypeptides present the potential to be used structurally unmodified or to serve as templates for ...
Hayashi, Mirian Akemi Furuie, Kerkis, Alexandre, Kerkis, Irina, Prieto-Silva, Álvaro Rossan, Rádis-Baptista, Gandhi, Tetsuo, Yamane   +5 more
core   +1 more source