Results 31 to 40 of about 2,560 (93)

Age‐related increase of CD38 directs osteoclastogenic potential of monocytic myeloid‐derived suppressor cells through mitochondrial dysfunction in male mice

Aging Cell, Volume 23, Issue 11, November 2024.
Aged M‐MDSCs have increased osteoclastogenesis potential. Transcriptomic analyses revealed the upregulation of mitochondrial oxidative phosphorylation and glucose metabolism genes, especially CD38 or NADase. A specific CD38 inhibitor reduced the mitochondrial oxygen consumption rate and glucose metabolism and inhibited the osteoclastogenic potential of
Ramkumar Thiyagarajan, Lixia Zhang, Omar D. Glover, Kyu Hwan Kwack, Sara Ahmed, Emma Murray, Nanda Kumar Yellapu, Jonathan Bard, Kenneth L. Seldeen, Spencer R. Rosario, Bruce R. Troen, Keith L. Kirkwood   +11 more
wiley   +1 more source

Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity

Pediatric Obesity, Volume 19, Issue 9, September 2024.
Summary Objective Children with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological‐related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association ...
Marcos Olvera‐Rojas, Abel Plaza‐Florido, Patricio Solis‐Urra, Francisco J. Osuna‐Prieto, Francisco B. Ortega   +4 more
wiley   +1 more source

Impaired instructive and protective barrier functions of the endothelial cell glycocalyx pericellular matrix is impacted in COVID‐19 disease

Journal of Cellular and Molecular Medicine, Volume 28, Issue 16, August 2024.
Abstract The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID‐19 disease impacts on endothelial cell properties that lead to much of its associated symptomatology. This places the endothelial cell as a prominent cell type to target therapeutically in the treatment of this disorder.
Margaret M. Smith, James Melrose
wiley   +1 more source

Evolution of fungal tuberculosis necrotizing toxin (TNT) domain‐containing enzymes reveals divergent adaptations to enhance NAD cleavage

Protein Science, Volume 33, Issue 7, July 2024.
Abstract Tuberculosis necrotizing toxin (TNT) is a protein domain discovered on the outer membrane of Mycobacterium tuberculosis (Mtb), and the fungal pathogen Aspergillus fumigatus. TNT domains have pure NAD(P) hydrolytic activity, setting them apart from other NAD‐cleaving domains such as ADP‐ribosyl cyclase and Toll/interleukin‐1 receptor homology ...
Eugenio Ferrario, Juha Pekka Kallio, Mahdi Emdadi, Øyvind Strømland, Johannes G. M. Rack, Mathias Ziegler   +5 more
wiley   +1 more source

Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Allergy, Volume 79, Issue 5, Page 1089-1122, May 2024.
Abstract The accumulation of senescent cells drives inflammaging and increases morbidity of chronic inflammatory lung diseases. Immune responses are built upon dynamic changes in cell metabolism that supply energy and substrates for cell proliferation, differentiation, and activation.
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. C. A. M. Van Esch, C. Stellato   +19 more
wiley   +1 more source

NAD metabolism: Role in senescence regulation and aging

Aging Cell, Volume 23, Issue 1, January 2024.
The biological impact of NAD boosting on aging and cellular senescence is not completely understood. It appears that NAD is necessary for senescent cell function. Therefore, NAD boosting may increase senescence‐induced dysfunction. Combination of NAD boosters with senolytic therapy may be a promising approach to improve NAD‐targeted interventions ...
Claudia Christiano Silva Chini, Heidi Soares Cordeiro, Ngan Le Kim Tran, Eduardo Nunes Chini   +3 more
wiley   +1 more source

Pathological Mechanisms in Sjögren's Disease Likely Involve the ADP-Ribosyl Cyclase Family Members: CD38 and CD157. [PDF]

Int J Mol Sci
Rosecka M, Kolackova M, Afshari M, Jozifkova E, Slezak R, Krejsek J, Radochova V.   +6 more
europepmc   +1 more source

Antibacterial ADP-ribosyl cyclase toxins inhibit bacterial growth by rapidly depleting NAD(P)^. [PDF]

J Biol Chem
Colautti J, Kim Y, Whitney JC.
europepmc   +1 more source

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins. [PDF]

J Biol Chem
Martinkus J, Terradot L, Jurėnas D, Cascales E.   +3 more
europepmc   +1 more source

Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice. [PDF]

Immunohorizons
Yahagi A, Iseki M, Yaku K, Nakagawa T, Itoh M, Mukai T, Ishihara K.   +6 more
europepmc   +1 more source