Results 41 to 50 of about 3,569 (120)

Single‐Cell RNAseq Identifies Heterogeneity in Myoblasts From Older Adults With Differences Related to Muscle Mass and Function

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Ageing is associated with the loss of muscle mass and function, with consequences for metabolic health, frailty and independence in later life. The aim of this study was to investigate the transcriptional heterogeneity of human proliferating muscle satellite/stem cells (myoblasts) from older adults and how this heterogeneity may ...
Mark A. Burton, Emma S. Garratt, Hanan Y. Sharkh, Matthew O. Hewitt, Elie Antoun, Leo D. Westbury, Elaine M. Dennison, Nicholas C. Harvey, Cyrus Cooper, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop   +11 more
wiley   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source

Exploiting Lactic Acid Bacteria for Regulating Autophagy to Improve Health in Foods and Supplements: A Recent Update

Food Frontiers, Volume 7, Issue 1, January 2026.
ABSTRACT Lactic acid bacteria (LAB) are frequently used as health supplements. They enhance digestion, regulate immunity, improve gut microbiota, and prevent and manage diseases. Autophagy has a crucial role in the prevention and treatment of tumors, cardiovascular diseases, and pathogenic infections.
Yang Chen, Fangyi Chen, Mengchen Li, Junfeng Xiao, Yang Mu, Chao Wang, Lusha Xia, Mingye Peng, Mengzhou Zhou   +8 more
wiley   +1 more source

Genomic Perspective on Heterogeneity of Organs and Body Aging

Aging Cell, Volume 25, Issue 1, January 2026.
Organ‐specific and whole‐body intrinsic aging metrics reveal heterogeneous organ aging, which potentially can arise from the interplay between static germline variation, somatic mutations, epigenetic drift, transposable elements, and mitochondrial DNA changes, highlighting genomic pathways for precision, organ‐targeted aging interventions.
Shabnam Salimi, Daniel Raftery, Luigi Ferrucci   +2 more
wiley   +1 more source

Conservation of a common motif in enzymes catalyzing ADP-ribose transfer. Identification of domains in mammalian transferases.

The Journal of biological chemistry, 1995
Bacterial toxin ADP-ribosyltransferases, e.g. diphtheria toxin (DT) and pertussis toxin, have in common consensus sequences involved in catalytic activity, which are localized to three regions. Region I is notable for a histidine or arginine; region II, approximately 50-75 amino acids downstream, is rich in aromatic/hydrophobic amino acids; and region ...
T, Takada, K, Iida, J, Moss
openaire   +1 more source

Influence of spermine and histones on a nuclear nucleosidase with ADP‐ribose transferase activity in ehrlich ascites cells [PDF]

FEBS Letters, 1968
Bock, K.W., Gäng, V.
openaire   +2 more sources

Inhibitors of nuclear ADP‐ribosyl transferase retard DNA repair after N‐methyl‐N‐nitroso‐urea [PDF]

FEBS Letters, 1981
Gray, Douglas A., Durkacz, Barbara W., Shall, Sydney   +2 more
openaire   +2 more sources

Targeting MARylation and DePARylation in Cancer Therapy: New Promising Therapeutic Opportunities. [PDF]

Cancers (Basel)
Cabeza-Fernández V, Ríos-Sola FJ, Martín-Oliva D, Borrego-Pérez J, Oliver FJ, YéLamos J, Rodríguez-Vargas JM.   +6 more
europepmc   +1 more source

Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited. [PDF]

Mol Psychiatry
Cohen-Armon M, Segal M.
europepmc   +1 more source