Results 171 to 180 of about 92,710 (320)

Stereoselectivity in beta-adrenoceptor of beta-adrenergic partial agonists, befunolol and carteolol! isolated rabbit ciliary body and guinea-pig taenia caecum.

, 1991
Hisashi Hagiwara, Katsuo Koike, Issei Takayanagi   +2 more
openalex   +1 more source

Beta-adrenergic agonist protects retinal pigment epithelium against hydroxycholoroquine toxicity via cAMP-PKA signal pathway

, 2020
Ruihua Zhang, Dan‐Ning Hu, Richard B. Rosen   +2 more
openalex   +1 more source

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential. [PDF]

Biomolecules
Cho YY, Kim S, Kim P, Jo MJ, Park SE, Choi Y, Jung SM, Kang HJ.   +7 more
europepmc   +1 more source

Dexmedetomidine suppresses glucose‐stimulated insulin secretion in pancreatic β‐cells

FEBS Open Bio, Volume 15, Issue 4, Page 634-646, April 2025.
Dexmedetomidine decreases insulin release and affects glucose metabolism; however, the specific mechanism remains largely unknown. This study shows clinically relevant doses of dexmedetomidine suppressed glucose‐stimulated insulin secretion. There was no significant difference in oxygen consumption rate, intracellular ATP levels, or caspase‐3/7 ...
Munenori Kusunoki, Kiichi Hirota, Tomohiro Shoji, Takeo Uba, Yoshiyuki Matsuo, Mikio Hayashi   +5 more
wiley   +1 more source

Catecholamines in sepsis: pharmacological insights and clinical applications-a narrative review. [PDF]

J Anesth Analg Crit Care
Belfiore J, Taddei R, Biancofiore G.
europepmc   +1 more source

Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives

Advanced Science, Volume 12, Issue 15, April 17, 2025.
Graphic illustration showing the strategic approaches based on the currently investigated evidence of psychedelics that suggests the challenges and how to address the prescription of mental disorders. These applicable avenues may provide substantial insight into distinguishing between brain networks and psychedelics.
Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo   +5 more
wiley   +1 more source

Comparison of efficacy and safety of mirabegron and vibegron in the treatment of Overactive Bladder (OAB) in older women: A systematic review and meta-analysis. [PDF]

PLoS One
Zhang J, Chi J, Lou K, Zhao J, Gao F, Cui Y.   +5 more
europepmc   +1 more source

TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study pinpoints TRIM56 as a viable candidate for promoting white adipose tissue browning and as a promising therapeutic target for addressing obesity and metabolic disorders. Functioning as an E3 ubiquitin ligase, TRIM56 facilitates the degradation of the TLE3 protein, thereby accelerating the thermogenic process and enhancing energy expenditure ...
Haojie Qin, Yi Zhong, Jinhui Huang, Yanli Miao, Meng Du, Kai Huang   +5 more
wiley   +1 more source

Tachycardia-Induced Cardiomyopathy Following Prolonged Ritodrine Infusion During Pregnancy: A Case Report. [PDF]

Cureus
Nakao M, Izawa M, Takamisawa I, Horiuchi C, Ohmori A, Katsuragi S.   +5 more
europepmc   +1 more source