Results 231 to 240 of about 8,200,615 (297)

Progress in Synthesis and Pharmacology of Telmisartan

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This review provides synthesis and understanding of telmisartan as an antihypertensive drug through two mechanisms of actions: RAAS inhibitor and PPARγ receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty ...
Megha, Richa Srivastava, Ram Singh
wiley   +1 more source

The impact of junk food on male fertility in mice: therapeutic interventions targeting advanced glycation end-products and oxidative stress. [PDF]

Sci Rep
Darmishonnejad Z, Hassan Zadeh V, Tavalaee M, Moazamian A, Aitken RJ, Drevet JR, Gharagozloo P, Nasr-Esfahani MH.   +7 more
europepmc   +1 more source

USP18 Serves as a Key Mediator of cGAS‐STING for Cardiac Aging in Diabetes

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Diabetes accelerates cardiac aging, but the molecular mechanisms that link metabolic stress to myocardial senescence remain insufficiently defined. This study investigated factors driving diabetes‐associated cardiac aging with a focus on the role of USP18.
Xunxi Deng, Zhiyi Yin, Shi Tai, Hejun Jiang, Yuying Zhou, Yongjun Wang, Liyao Fu   +6 more
wiley   +1 more source

Advanced glycation end-products and sclerostin are elevated across diabetes phenotypes and associated with vertebral fractures in type 2 diabetes. [PDF]

BMC Endocr Disord
Taskin Kursun S, Imre E, Gogas Yavuz D.
europepmc   +1 more source

Extracellular high mobility group box 1 as a UV‐induced alarmin driving cutaneous inflammation and photoaging via TLR4 signaling

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
UV irradiation triggers the active release of HMGB1 from skin cell nuclei into the extracellular space. Extracellular HMGB1 binds TLR4 receptors on neighboring cells, initiating a signaling cascade that upregulates proinflammatory cytokines (IL‐1β, IL‐6, IL‐8, and TNF‐α). This chronic inflammatory state drives neutrophil infiltration and collagen fiber
Qian Liufu, Zhaoping Qin, Yan Yan, Yiru Xu, Tianyuan He, Yingchun Liu, Yaping Xiang, Chunfang Guo, Taihao Quan   +8 more
wiley   +1 more source

Hyperglycemia, receptor for advanced glycation end products, and small airways dysfunction in asthma. [PDF]

Ann Allergy Asthma Immunol
Salas PS, Villareal DT, Tejwani V, Koirala A, Coarfa C, McCormack MC, Hanania NA, Wu TD.   +7 more
europepmc   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, Volume 12, Issue 3, Page 219-230, September 2026.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

Association of Corneal Biomechanical Properties with Fingertip-Measured Advanced Glycation End Products and Carotenoids in Glaucoma Patients. [PDF]

J Clin Med
Takagi K, Ohtani H, Ida C, Koike M, Murakami K, Tanito M.   +5 more
europepmc   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source