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Advanced glycation end products: A nephrologist's perspective
American Journal of Kidney Diseases, 2000Advanced glycation end products (AGEs) are a heterogeneous group of molecules that accumulate in plasma and tissues with advancing age, diabetes, and renal failure. There is emerging evidence that AGEs are potential uremic toxins and may have a role in the pathogenesis of vascular and renal complications associated with diabetes and aging.
D S, Raj +3 more
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Serum advanced glycation end products (AGEs) are associated with insulin resistance
Diabetes/Metabolism Research and Reviews, 2011 Background: In addition to the important role of advanced glycation end products (AGEs) in the pathogenesis of diabetic vascular complications, recent data suggest that advanced glycation end products can also impair insulin action in vitro.
Wong, Y +7 more
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Analytical Biochemistry, 2004
Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown.
Valencia, J.V. +6 more
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Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown.
Valencia, J.V. +6 more
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Advanced Glycation End Products
2011Prolonged hyperglycemia, dyslipidemia and oxidative stress in diabetes result in the increased production and accumulation of advanced glycation end products (AGEs) in the kidney. Covalent AGE modifications significantly influence the structure and function of key protein targets.
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Advanced glycation end products and diabetic retinopathy
Amino Acids, 2011Retinopathy is a serious microvascular complication of diabetes and a major cause of blindness in young adults, worldwide. Early diabetic retinopathy is characterized by a loss of pericytes from retinal capillaries, the appearance of acellular capillaries and microaneurysms, and a breakdown of the blood-retinal barrier. In later stages, this can evolve
Ross, Milne, Seymour, Brownstein
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Advanced Glycation End Products and Insulin Resistance
Current Pharmaceutical Design, 2008Non-enzymatic modification of proteins by reducing sugars, a process that is also known as Maillard reaction, leads to the formation of advanced glycation end products (AGEs) in vivo. There is a growing body of evidence that formation and accumulation of AGEs progress during normal aging, and at an extremely accelerated rate under diabetes, thus being ...
Hiroyuki, Unoki, Sho-ichi, Yamagishi
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Advanced glycation end products, diabetes and ageing
Zeitschrift für Gerontologie und Geriatrie, 2007Advanced glycation end products (AGEs) are formed in vivo by a non-enzymatic reaction of proteins with carbohydrates and accumulate in many tissues during ageing. They are discussed as being responsible for many age- and diabetes-related diseases. On the other hand, AGEs are formed by the heating of food and are taken up by the nutrition.
N, Nass +6 more
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Advanced glycation end-products and peritoneal sclerosis
Seminars in Nephrology, 2004Long-term continuous ambulatory peritoneal dialysis (CAPD) often causes peritoneal fibrosis and sclerosis with a loss of function, and some CAPD patients develop sclerosing encapsulating peritonitis. Glucose-based peritoneal dialysis fluids readily produce glucose degradation products by heat sterilization, and glucose degradation products accelerate ...
Sakurako, Nakamura, Toshimitsu, Niwa
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Advanced glycation end products, diabetes, and the brain
Neurology, 2011Type 2 diabetes is associated with declines in cognition, including learning and memory, mental flexibility, and mental speed. The degree of decrement tends to be modest and evolves slowly as a person ages. However, some patients diagnosed with type 2 diabetes experience a different course, with increased risk of more severe cognitive deficits ...
Laura H, Coker, Lynne E, Wagenknecht
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Advanced glycation end products and diabetic complications
Expert Opinion on Investigational Drugs, 2002Diabetic complications are major cause of morbidity and mortality in patients with diabetes. While the precise pathogenic mechanism(s) underlying conditions such as diabetic retinopathy, diabetic nephropathy and increased risk of atherosclerosis remain ill-defined, it is clear that hyperglycaemia is a primary factor that initiates and promotes ...
Stitt, Alan, Jenkins, A.J., Cooper, M.E.
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