Results 21 to 30 of about 83,278 (208)

Advanced Glycation End-Products Suppress Mitochondrial Function and Proliferative Capacity of Achilles Tendon-Derived Fibroblasts [PDF]

, 2019
Debilitating cases of tendon pain and degeneration affect the majority of diabetic individuals. The high rate of tendon degeneration persists even when glucose levels are well controlled, suggesting that other mechanisms may drive tendon degeneration in ...
Cannon, Jason R., Carroll, Chad C., Foguth, Rachel, Kuang, Shihuan, Patel, Shivam H., Sabbaghi, Arman, Saw, Shannon K., Shannahan, Jonathan H., Yue, Feng   +8 more
core   +2 more sources

Association of advanced glycation end products in Dupuytren disease

Journal of Orthopaedic Surgery and Research, 2018
Background Advanced glycation end products are associated with aging, hyperglycemia, and oxidative stress. Accumulation of advanced glycation end products can cause various pathological conditions; however, the association of Dupuytren’s disease with ...
Fumiaki Takase, Yutaka Mifune, Atsuyuki Inui, Yasuhiro Ueda, Takeshi Kataoka, Takeshi Kokubu, Ryosuke Kuroda   +6 more
doaj   +1 more source

Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts

Translational Oncology, 2022
The molecular implications of food consumption on cancer etiology are poorly defined. The rate of nutrition associated non-enzymatic glycoxidation, a reaction that occurs between reactive carbonyl groups on linear sugars and nucleophilic amino, lysyl and
Bradley A. Krisanits, Pamela Woods, Lourdes M. Nogueira, Demarcus D. Woolfork, Courtney E. Lloyd, Andrew Baldwin, Callan C. Frye, Kendell D. Peterson, Sean D. Cosh, Qi-Jin Guo, Laura S. Spruill, Michael B. Lilly, Kristi Helke, Hong Li, George S. Hanna, Mark T. Hamann, Courtney Thomas, Mahtabuddin Ahmed, Monika B. Gooz, Victoria J. Findlay, David P. Turner   +20 more
doaj   +1 more source

Advanced Glycation End Products, Soluble Receptor for Advanced Glycation End Products, and Risk of Colorectal Cancer [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2011
Abstract Background: Advanced glycation end products (AGE) accumulate in human tissue proteins during aging, particularly under hyperglycemia conditions. AGEs induce oxidative stress and inflammation via the receptor for AGEs (RAGE) and soluble RAGE (sRAGE) can neutralize the effects mediated by RAGE–ligand engagement ...
Stephanie J. Weinstein, Philip R. Taylor, Jarmo Virtamo, Barry I. Graubard, Demetrius Albanes, Li Jiao, Rachael Z. Stolzenberg-Solomon   +6 more
openaire   +3 more sources

NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification [PDF]

, 2005
The non-enzymatic reaction between reducing sugars and long-lived proteins in vivo results in the formation of glycation and advanced glycation end products, which alter the properties of proteins including charge, helicity, and their tendency to ...
Howard, Mark J., Smales, Christopher Mark   +1 more
core   +1 more source

Soluble levels of receptor for advanced glycation endproducts and dysfunctional high-density lipoprotein in persons infected with human immunodeficiency virus: ACTG NWCS332. [PDF]

, 2018
The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear.
Aberg, Judith A, Currier, Judith S, Danoff, Ann, Kelesidis, Theodoros, Kendall, Michelle A, Schmidt, Ann Marie   +5 more
core   +1 more source

Advanced Glycation End Products and Receptor for Advanced Glycation End Products in AA Amyloidosis

The American Journal of Pathology, 2003
Advanced glycation end products (AGEs) may be involved in either amyloidogenesis or complications related to amyloid. We hypothesized that AGEs may influence the pathogenesis of AA amyloidosis, and investigated the spatial and temporal relationship between AGEs, carboxy methyl lysine (CML), the AGE receptor (RAGE), and AA amyloid in humans and mice ...
Sophie Mansfeld, B. Stix, Christoph Röcken, Frank Bühling, Kay Stubenrauch, Bernd Weigle, Mona Schwan, Wolfgang Saeger, Rosemarie Kientsch-Engel   +8 more
openaire   +3 more sources

Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease [PDF]

, 2015
Advanced Glycation End-Products (AGEs) are signaling proteins associated to several vascular and neurological complications in diabetic and non-diabetic patients.
Avtaar Singh, Sanjeet Singh, Chello, Massimo, DI DOMENICO, Fabio, Nappi, Francesco, Nenna, Antonio, Spadaccio, Cristiano, Sutherland, Fraser W   +6 more
core   +2 more sources

Advanced Glycation End Products and Diabetic Complications [PDF]

The Korean Journal of Physiology & Pharmacology, 2014
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation end products (AGEs) play an important role in the pathogenesis of diabetic complications like retinopathy, nephropathy ...
Varun Parkash Singh, Nirmal Singh, Anjana Bali, Amteshwar Singh Jaggi   +3 more
openaire   +3 more sources

Advanced glycation end products as a biomarker for incisional hernia [PDF]

, 2017
Background: Incisional hernia is one of the most frequent complications after abdominal surgery, with incidences up to 30%. A reliable biomarker for the prediction of this complication is lacking. Advanced glycosylation end products (AGEs), also known as
Cabezas, M.C., Eker, H.H. (Hasan), Ham, A.C. (Arie) van der, Harlaar, J.J. (Joris Jan), Jeekel, J. (Hans), Lange, J.F. (Johan), Vakalopoulos, K.A. (Konstantinos), Vrijland, W.W. (Wietske)   +7 more
core   +4 more sources