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Advanced glycation end products and human diseases
Journal of Biological ResearchProteins, lipids, and nucleic acids can undergo non-enzymatic glycation and oxidation, leading to the formation of Advanced Glycation End products (AGEs).
Hamad Abu Zahra
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Research Progress on Natural Products Inhibiting Advanced Glycation End Products [PDF]
Shipin KexueGlycation is the non-enzymatic reaction between sugars (glucose and fructose) and proteins or lipids, giving rise to the formation of advanced glycation end products (AGEs).
QI Yawei, LIU Haochi, LIU Jifeng
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The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]
, 2013 The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
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Dietary Advanced Glycation End Products and Aging [PDF]
Nutrients, 2010 Advanced glycation end products (AGEs) are a heterogeneous, complex group of compounds that are formed when reducing sugar reacts in a non-enzymatic way with amino acids in proteins and other macromolecules. This occurs both exogenously (in food) and endogenously (in humans) with greater concentrations found in older adults.
Luevano-Contreras, Claudia +1 more
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Journal of the Formosan Medical Association, 2015 Blockade of advanced glycation end-products (AGE) is able to reduce diabetic complications and control periodontitis. This study aimed to determine whether the application of aminoguanidine (AG), an AGE inhibitor, or N-phenacylthiazolium bromide (PTB ...
Sheng-Chueh Tsai +6 more
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Advanced glycation end‐products and the kidney [PDF]
European Journal of Clinical Investigation, 2010 Eur J Clin Invest 2010; 40 (8): 742–755AbstractBackground Advanced glycation end‐products (AGEs) are increased in situations with hyperglycemia and oxidative stress such as diabetes mellitus. They are products of nonenzymatic glycation and oxidation of proteins and lipids.
Martin, Busch +3 more
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Research Progress on Advanced Glycation End Products in Aging-related Diseases
Guoji laonian yixue zazhiAging is an inherent physiological phenomenon that occurs throughout human life. Numerous theories have been proposed to elucidate the distinctive features of aging, encompassing oxidative stress, imbalances in protein homeostasis, deterioration of gene ...
Yanling Shen +3 more
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Advanced glycation end-products in diabetic nephropathy [PDF]
Nephrology Dialysis Transplantation, 1996 Advanced glycation end-products (AGEs) are the pigmented and fluorescent adduct formed by a non-enzymatic reaction between sugar and protein. Since AGEs are generated in high glucose milieu, then induce the structural and functional alteration of matnx proteins, and have biological effects on various kinds of cells including mesangial cells, AGEs have ...
S, Sugiyama +6 more
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Advanced glycation end-products induce endoplasmic reticulum stress in human aortic endothelial cells [PDF]
, 2013 Background: Advanced glycation end products (AGEs), the final products of the Maillard reaction, have been shown to impair endothelial proliferation and function, thus contributing to endothelial cell injury present in diabetes, inflammatory and ...
Adamopoulos, Christos +5 more
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Advanced glycation end products
Atherosclerosis, 2016 Patients with peripheral artery disease (PAD) suffer from widespread atherosclerosis. Partly due to the growing awareness of cardiovascular disease, the incidence of PAD has increased considerably during the past decade. It is anticipated that algorithms to identify high risk patients for cardiovascular events require being updated, making use of novel
de Vos, Lisanne C. +4 more
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