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Advanced glycation end products and diabetic complications
Expert Opinion on Investigational Drugs, 2002Diabetic complications are major cause of morbidity and mortality in patients with diabetes. While the precise pathogenic mechanism(s) underlying conditions such as diabetic retinopathy, diabetic nephropathy and increased risk of atherosclerosis remain ill-defined, it is clear that hyperglycaemia is a primary factor that initiates and promotes ...
Stitt, Alan, Jenkins, A.J., Cooper, M.E.
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Analytical Biochemistry, 2004
Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown.
Valencia, J.V. +6 more
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Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown.
Valencia, J.V. +6 more
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Advanced glycation end products, diabetes and ageing
Zeitschrift für Gerontologie und Geriatrie, 2007Advanced glycation end products (AGEs) are formed in vivo by a non-enzymatic reaction of proteins with carbohydrates and accumulate in many tissues during ageing. They are discussed as being responsible for many age- and diabetes-related diseases. On the other hand, AGEs are formed by the heating of food and are taken up by the nutrition.
N, Nass +6 more
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Advanced glycation end-products and peritoneal sclerosis
Seminars in Nephrology, 2004Long-term continuous ambulatory peritoneal dialysis (CAPD) often causes peritoneal fibrosis and sclerosis with a loss of function, and some CAPD patients develop sclerosing encapsulating peritonitis. Glucose-based peritoneal dialysis fluids readily produce glucose degradation products by heat sterilization, and glucose degradation products accelerate ...
Sakurako, Nakamura, Toshimitsu, Niwa
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Advanced glycation end products, diabetes, and the brain
Neurology, 2011Type 2 diabetes is associated with declines in cognition, including learning and memory, mental flexibility, and mental speed. The degree of decrement tends to be modest and evolves slowly as a person ages. However, some patients diagnosed with type 2 diabetes experience a different course, with increased risk of more severe cognitive deficits ...
Laura H, Coker, Lynne E, Wagenknecht
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Role of dietary advanced glycation end products
Current Opinion in Lipidology, 2017Refereed/Peer ...
Peter, Clifton, Jennifer, Keogh
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Advanced Glycation End Products and Cardiovascular Disease
Current Diabetes Reviews, 2008Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Advanced glycation end products [AGEs] seem to play an important role for the development and/or progression of CVD mainly through induction of oxidative stress and inflammation.
Melpomeni, Peppa, Sotirios A, Raptis
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Advanced Glycation End Products in Renal Failure
Journal of Renal Nutrition, 2006Cellular and extracellular proteins suffer significant damage in vivo by glycation. Physiological proteolysis of proteins damaged by glycation forms glycation free adducts that are released into plasma for urinary excretion. Inefficient elimination of these free adducts in uremia leads to their accumulation.
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The dynamic roles of advanced glycation end products
Advanced glycation end products (AGEs) are a heterogeneous group of potentially harmful molecules that can form as a result of a non-enzymatic reaction between reducing sugars and proteins, lipids, or nucleic acids. The total body pool of AGEs reflects endogenously produced AGEs as well as exogeneous AGEs that come from sources such as diet and the ...Mariyam, Khalid, Abdu, Adem
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Advanced Glycation End Products in Meat during Processing and Storage: A Review
Food Reviews International, 2023Ming Huang
exaly