Results 201 to 210 of about 24,686 (257)

An Angiotensin II Receptor Blocker Suppresses Glucose‐Induced Oxidative Stress in Human Rotator Cuff‐Derived Cells

Journal of Orthopaedic Research, Volume 44, Issue 7, July 2026.
ABSTRACT Rotator cuff tears are among the most common shoulder disorders, and their incidence increases with age. Hyperglycemic conditions are known to enhance oxidative stress and inflammatory signaling in various tissues, potentially contributing to tendon degeneration.
Shunsaku Takigami, Yutaka Mifune, Atsuyuki Inui, Kohei Yamaura, Issei Shinohara, Masaya Kusunose, Shuya Tanaka, Shin Osawa, Tomoyuki Matsumoto, Ryosuke Kuroda   +9 more
wiley   +1 more source

Matrine Attenuates Neurological Deficits and Neuroinflammation by Inhibiting the HMGB1/RAGE Axis and Ferroptosis in Intracerebral Hemorrhage Mice

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 7, July 2026.
ABSTRACT Intracerebral hemorrhage (ICH) is a life‐threatening stroke subtype that lacks effective drug therapy. In the context of ICH, neuroinflammation, and ferroptosis are key contributors to secondary brain injury. In this study, we assessed the neuroprotective effects of matrine (MAT) and its mechanism of action involving the HMGB1/RAGE axis in an ...
Pan‐Di Chen, Tao‐Tao Shi, Dan‐Yang Hu, Xiao‐Na Su, Jian‐Xiang Jin, Mao‐Song Chen, Hao Wang, Wei Chen   +7 more
wiley   +1 more source

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Bone Aging by Advanced Glycation End Products

Bone Aging by Advanced Glycation End Products
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Advanced glycation end products (AGEs) in oral pathology

Archives of Oral Biology, 2018
Maillard advanced glycation end products (AGEs) are connected with high dry temperature food processing, color and flavor modification of food products. Oral cavity pathology is strongly influenced by dietary intake. The aim of the present paper is to update current data regarding the sources and metabolism of AGEs, their impact on oral cavity tissues,
Jared Gerlach, Massimo Collino, Aranka Ilea   +2 more
exaly   +3 more sources