Results 181 to 190 of about 24,686 (257)
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley +1 more source
Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen +2 more
wiley +1 more source
Among 3.8 million dementia‐related deaths in U.S. adults aged ≥65 years during 19992020, diabetes was documented in 6.2%. Mortality increased sharply until 2009 and then stabilized, with substantial age, racial/ethnic, and geographic disparities, highlighting the need for targeted prevention and continued surveillance. ABSTRACT Background Diabetes is a
Aasim Ali +14 more
wiley +1 more source
Clinical Factors and Biomarkers Associated with Depressive Disorders in Older Patients Affected by Chronic Kidney Disease (CKD): Does the Advanced Glycation End Products (AGEs)/RAGE (Receptor for AGEs) System Play Any Role? [PDF]
Buoli M +7 more
europepmc +1 more source
Roles of Microglia in Cerebral Small Vessel Disease
Chronic cerebral hypoperfusion triggers microglial activation in cerebral small vessel disease (CSVD). Activated microglia drive neuroinflammation, oxidative stress, and blood–brain barrier disruption, leading to white matter hyperintensities, enlarged perivascular spaces, and other neuroimaging features.
Chenyang Jin +7 more
wiley +1 more source
Advanced Glycation End Products of Maillard Reaction and Aging.
Takeya, Motohiro, Takahashi, Kiyoshi
openaire +2 more sources
Tendon injuries in diabetes heal poorly, with unclear drivers of extracellular matrix disruption and altered mechanics. This narrative review synthesizes in vitro, animal, and human studies, highlighting serum advanced glycation end products as potential systemic contributors.
Eric J. Gutierrez +3 more
wiley +1 more source
PXDN expression is markedly upregulated in diabetic nephropathy and, versus NF‐κB and oxidative stress markers, shows superior diagnostic performance (AUC 0.79; 90% specificity), supporting PXDN as a sensitive, specific non‐invasive biomarker for early DN.
Zakira Hanin +6 more
wiley +1 more source

