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Advanced Glycation End Products of the Maillard Reaction and Their Relation to Aging
Gerontology, 2009Long-term incubation of proteins with glucose leads to advanced glycation end products (AGE). Demonstration of AGE in vivo as well as determination of its main structure are crucial to elucidate its potential link to aging processes and diabetic complications.
S, Horiuchi, N, Araki
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Advanced Glycation End Products (AGEs) and Diabetic Vascular Complications
Current Diabetes Reviews, 2005Diabetic vascular complication is a leading cause of acquired blindness, end-stage renal failure, a variety of neuropathies and accelerated atherosclerosis, which could account for disabilities and high mortality rates in patients with diabetes. Chronic hyperglycemia is essentially involved in the development and progression of diabetic micro- and ...
Sho-ichi, Yamagishi +2 more
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Involvement of Advanced Glycation End-products (AGEs) in Alzheimers Disease
Current Alzheimer Research, 2004The advanced stage of the glycation process (one of the post-translational modifications of proteins) leads to the formation of advanced glycation end-products (AGEs) and plays an important role in the pathogenesis of angiopathy in diabetic patients.
Masayoshi, Takeuchi +7 more
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The role of advanced glycation end products in retinal ageing and disease
Biochimica et Biophysica Acta (BBA) - General Subjects, 2009The retina is exposed to a lifetime of potentially damaging environmental and physiological factors that make the component cells exquisitely sensitive to age-related processes. Retinal ageing is complex and a raft of abnormalities can accumulate in all layers of the retina.
Glenn, Josephine V., Stitt, Alan W.
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Role of Advanced Glycation End Products (AGEs) in Osteoporosis in Diabetes
Current Drug Targets, 2011Recent meta-analyses have revealed that the risk of bone fracture is increased in both type 1 and type 2 diabetic patients. Low bone mineral density (BMD) can not necessarily explain the link, because BMD is increased rather than decreased in type 2 diabetes, while it is consistently low in type 1 diabetes subjects.
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Role of Advanced Glycation End Products in Aging Collagen
Gerontology, 1998The collagen structure of young and old rats was examined using a scanning force microscope (SFM). Rat tail tendons of 8- and 24-month-old Wistar rats were frayed by two blades and examined using a Nanoscope III SFM. In the same tendons, the pentosidine concentrations, a marker of the Maillard reaction, were determined by HPLC.
P. Odetti +5 more
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[Importance of advanced glycation end products--AGE products].
Bratislavske lekarske listy, 1998Recent experimental findings suggest that free oxygen radicals and AGEs may be significantly involved in the onset and development of chronic diabetic complications and Alzheimer's disease. The presented review summarizes knowledge on structure and rise of these products in vitro and in vivo and the chemical and biological properties of advanced ...
V, Jakus, J, Cársky, M, Hrnciarová
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Advanced Glycation End Products (AGEs) in Diabetic Complications
2017Hyperglycemic condition in diabetes accelerates formation of advanced glycation end products (AGEs) that are formed as a result of series of reaction between reducing sugars and proteins. Accumulation of AGEs has been implicated in development of insulin resistance as well as in the pathogenesis of diabetic complications.
Shweta Bhat +3 more
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[Advanced glycation end products (AGEs) and renal failure].
Przeglad lekarski, 2006In the last decade a central role has been attributed to advanced glycation end products (AGE's) in the progression of accelerated atherosclerosis and progresion of chronic renal failure, especially in diabetic nephropathy. Deleterious effects of high AGE's concentration was observed mainly in diabetic hemodialyzed patients. D. M.
Robert, Kurowski, Jacek, Manitius
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