Results 81 to 90 of about 42,909 (288)

One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]

, 2015
Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA, DE SANTIS, Elena, Limana, F, Perrone, Ga, POLLETTA, LUCIA, RUNCI, ALESSANDRA, RUSSO, Matteo Antonio, SANSONE, LUIGI, TAFANI, MARCO   +8 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

AKTIVITAS ANTIFOTOOKSIDASI DAN PENGHAMBATAN PEMBENTUKKAN AGEs (ADVANCED GLYCATION END PRODUCTS) EKSTRAK KULIT BUAH PISANG GOROHO (Musa acuminate) [PDF]

, 2018
AKTIVITAS ANTIFOTOOKSIDASI DAN PENGHAMBATAN PEMBENTUKKAN AGEs (ADVANCED GLYCATION END PRODUCTS) EKSTRAK KULIT BUAH PISANG GOROHO (Musa acuminate)Jane Beatrix Rety Kowaas1), Edi Suryanto2), Defny Silvia Wewengkang3)1)Program studi Farmasi FMIPA Unsrat ...
Kowaas, Jane B.R.
core   +2 more sources

Acetoacetate promotes the formation of fluorescent advanced glycation end products (AGEs) [PDF]

Journal of Biomolecular Structure and Dynamics, 2016
Acetoacetate (AA) is an important ketone body, which produces reactive oxygen species (ROS). Advanced glycation end products (AGEs) are defined as final products of glycation process whose production is influenced by the levels of ROS. The accumulation of AGEs in the body contributes to pathogenesis of many diseases including complications of diabetes,
Mousa, Bohlooli, Mansour, Ghaffari-Moghaddam, Mostafa, Khajeh, Zohre, Aghashiri, Nader, Sheibani, Ali Akbar, Moosavi-Movahedi   +5 more
openaire   +2 more sources

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, EarlyView.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Role of advanced glycation end products related to the onset of diabetic kidney disease complications

Clinical and Biomedical Research, 2017
Advanced glycation end products are known to play an important role in the diabetes complications, such as diabetic nephropathy. Most known pathways of diabetic complications involve oxidative stress, that have pivotal role in cell dysfunction onset and ...
Maria Luiza Almeida de Paula, Ana Marina Rodrigues Villela, Mauricio Massucati Negri, Salim Kanaan, Luciene de Carvalho Cardoso Weide   +4 more
doaj   +2 more sources

Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I [PDF]

, 2012
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability ...
Ferrucci, Luigi, Fried, Linda P., Schaumberg, Debra Ann, Semba, Richard D., Sun, Kai, Varadhan, Ravi   +5 more
core   +4 more sources

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

Advanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang, Chenle Dong, Lefeng Su, Zhiqiang Liu, Lingyi Hu, Qishu Jin, Hao Chen, Chunlong Zhang, Yihao Wu, Jiang Chang, Zhaowenbin Zhang, Jiandong Yuan   +11 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

The Establishment and Application of a Method for the Systematic Evaluation, Screening, and Efficacy Verification of Various Cosmetic Ingredients Based on the Inhibition and Degradation of Advanced Glycation End Products

Cosmetics
Advanced glycation end products (AGEs) formed via glycation reactions negatively impact skin health by diminishing barrier function and elasticity and causing dullness. This study systematically evaluated the inhibitory and degradative capabilities of 24
Linlin Xu, Yuxin Song, Daichi Murata, Linxin Zheng, Guhui Chen, Junyong Song, Congfen He   +6 more
doaj   +1 more source