The effects of temperature acclimation on swimming performance in the pelagic Mahi-mahi (Coryphaena hippurus) [PDF]
Mahi-mahi (Coryphaena hippurus) are a highly migratory pelagic fish, but little is known about what environmental factors drive their broad distribution. This study examined how temperature influences aerobic scope and swimming performance in mahi. Mahi were acclimated to four temperatures spanning their natural range (20, 24, 28, and 32{\deg}C; 5-27 ...
arxiv +1 more source
Life as the Only Reason for the Existence of N2-O2-Dominated Atmospheres [PDF]
The Earth's N2-dominated atmosphere is a very special feature. Firstly, N2 as main gas is unique on the terrestrial planets in the inner solar system and gives a hint for tectonic activity. Studying the origins of atmospheric nitrogen and its stability provides insights into the uniqueness of the Earth's habitat.
arxiv +1 more source
Self-Organization and Fractality in the Metabolic Process of Glycolysis [PDF]
Within a mathematical model, the metabolic process of glycolysis is studied. The general scheme of glycolysis is considered as a natural result of the biochemical evolution. By using the theory of dissipative structures, the conditions of self-organization of the given process are sought.
arxiv +1 more source
Lower glycolysis carries a higher flux than any biochemically possible alternative [PDF]
The universality of many pathways of core metabolism suggests a strong role for evolutionary selection, but it remains unclear whether existing pathways have been selected from a large or small set of biochemical possibilities. To address this question, we construct "in silico" all possible biochemically feasible alternatives to the trunk pathway of ...
arxiv +1 more source
Designing an AI Health Coach and Studying its Utility in Promoting Regular Aerobic Exercise [PDF]
Our research aims to develop interactive, social agents that can coach people to learn new tasks, skills, and habits. In this paper, we focus on coaching sedentary, overweight individuals (i.e., trainees) to exercise regularly. We employ adaptive goal setting in which the intelligent health coach generates, tracks, and revises personalized exercise ...
arxiv +1 more source
Main-chain poly(ionic liquid)-derived nitrogen-doped micro/mesoporous carbons for CO2 capture and selective aerobic oxidation of alcohols [PDF]
Sustainable development and the recent fast growing global demands for energy and functional chemicals urgently call for effective methods for CO2 remediation and efficient metal-free catalysts for selective oxidation of aromatic alcohol. Herein, a unique main-chain poly(ionic liquid) (PIL) is employed as the precursor to prepare nitrogen doped micro ...
arxiv +1 more source
Warburg Effect due to Exposure to Different Types of Radiation [PDF]
Cancer cells maintain a high level of aerobic glycolysis (the Warburg effect), which is associated with their rapid proliferation. Many studies have reported that the suppression of glycolysis and activation of oxidative phosphorylation can repress the growth of cancer cells through regulation of key regulators.
arxiv
Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature [PDF]
Background: Tumours are diverse ecosystems with persistent heterogeneity in various cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and reprogramming of energy-metabolism for aerobic glycolysis. This heterogeneity has consequences for diagnosis, treatment, and disease progression.
arxiv
Competition driven cancer immunoediting [PDF]
It is a well-established fact that tumors up-regulate glucose consumption to meet increasing demands for rapidly available energy by switching to purely glycolytic mode of glucose metabolism. What is often neglected is that cytotoxic cells of the immune system also have increased energy demands and also switch to pure glycolysis when they are in an ...
arxiv
Model for Acid-Mediated Tumour Invasion with Chemotherapy Intervention I: Homogeneous Populations [PDF]
The acid-mediation hypothesis, that is, the hypothesis that acid produced by tumours, as a result of aerobic glycolysis, provides a mechanism for invasion, has so far been considered as a relatively closed system. The focus has mainly been on the dynamics of the tumour, normal-tissue, acid and possibly some other bodily components, without considering ...
arxiv