Results 21 to 30 of about 356,678 (297)

Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis

Blood Advances, 2023
Key Points • Combined deletion of pyruvate dehydrogenase kinase (PDK) 2 and 4 inhibits platelet function and arterial thrombosis.• PDK2/4 contributes to platelet biology by regulating pyruvate dehydrogenase phosphorylation and aerobic glycolysis in ...
G. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan   +5 more
semanticscholar   +1 more source

HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m6A-MYC expression

International Journal on Biological Sciences, 2022
Enhanced aerobic glycolysis constitutes an additional source of energy for tumor proliferation and metastasis. Human papillomavirus (HPV) infection is the main cause of cervical cancer (CC); however, the associated molecular mechanisms remain poorly ...
Chenchen Hu, Tian Liu, C. Han, Yuxin Xuan, Dongbo Jiang, Yuanjie Sun, Xi-yang Zhang, Wenxin Zhang, Yiming Xu, Yang Liu, Jingyu Pan, Jing Wang, Jiang-li Fan, Yinggang Che, Yinan Huang, Jiaxing Zhang, Jiaqi Ding, Shuya Yang, Kun Yang   +18 more
semanticscholar   +1 more source

Oleanolic acid suppresses aerobic glycolysis in cancer cells by switching pyruvate kinase type M isoforms. [PDF]

PLoS ONE, 2014
Warburg effect, one of the hallmarks for cancer cells, is characterized by metabolic switch from mitochondrial oxidative phosphorylation to aerobic glycolysis.
Jia Liu, Ning Wu, Leina Ma, Ming Liu, Ge Liu, Yuyan Zhang, Xiukun Lin   +6 more
doaj   +1 more source

Aerobic Glycolysis in Osteoblasts [PDF]

Current Osteoporosis Reports, 2014
Osteoblasts, the chief bone-making cells in the body, are a focus of osteoporosis research. Although teriparatide, a synthetic fragment of the human parathyroid hormone (PTH), has been an effective bone anabolic drug, there remains a clinical need for additional therapeutics that safely stimulates osteoblast number and function.
Emel, Esen, Fanxin, Long
openaire   +2 more sources

Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway

Mediators of Inflammation, 2021
It has been considered that glucose fluctuation (GF) plays a role in renal injury and is related to diabetic nephropathy (DN) development. But the mechanism is still unclear. Aerobic glycolysis has become a topical issue in DN in recent years.
Xiaomei Fu, Jianfang Zhang, Xuanjie Huang, Zhifeng Mo, Ziyang Sang, Wenfei Duan, Wenfeng Huang   +6 more
doaj   +1 more source

FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis

Cell Death and Disease, 2022
Although FOXD1 has been found to be involved in the malignant processes of several types of cancers, its role in pancreatic cancer (PC) is not well understood. This study aimed to investigate the expression and function of FOXD1 in PC.
K. Cai, Shiyu Chen, Changhao Zhu, Lin Li, Chao Yu, Zhiwei He, Chengyi Sun   +6 more
semanticscholar   +1 more source

EIF4A3-induced circARHGAP29 promotes aerobic glycolysis in docetaxel-resistant prostate cancer through IGF2BP2/c-Myc/LDHA signaling.

Cancer Research, 2021
Docetaxel-based chemotherapy is a standard-of-care treatment for metastatic prostate cancer (PCa), and chemoresistance remains a major challenge in clinical practice.
Xingkang Jiang, Shanqi Guo, Shuo Wang, Yangyi Zhang, Haojie Chen, Yong Wang, Ranlu Liu, Y. Niu, Yong Xu   +8 more
semanticscholar   +1 more source

Aerobic glycolysis enhances HBx-initiated hepatocellular carcinogenesis via NF-κBp65/HK2 signalling

Journal of experimental & clinical cancer research : CR, 2022
Background Aerobic glycolysis has been recognized as one of the growth-promoting metabolic alterations of cancer cells. Emerging evidence indicates that nuclear factor κB (NF-κB) plays significant roles in metabolic adaptation in normal cells and cancer ...
Lingjun Chen, Xian-yi Lin, Yiming Lei, Xuan Xu, Qi Zhou, Yan Chen, Huiling Liu, Jie Jiang, Yidong Yang, Feng-ping Zheng, Bin Wu   +10 more
semanticscholar   +1 more source

Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin

Respiratory Research, 2022
Background Up-regulation of aerobic glycolysis has been reported as a characterization of asthma and facilitates airway inflammation. We has been previously reported that short isoform thymic stromal lymphopoietin (sTSLP) could reduce inflammation in ...
Changhui Yu, Wufeng Huang, Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Haijing Zhao, Laiyu Liu, Hangming Dong, Fei Zou, Shaoxi Cai   +10 more
doaj   +1 more source

Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis

Frontiers in Molecular Biosciences, 2022
Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without ...
Ni Fan, Hui Fu, Xuchen Feng, Yatong Chen, Jingyu Wang, Yuqi Wu, Yuhong Bian, Yingpeng Li, Yingpeng Li   +8 more
doaj   +1 more source