Results 31 to 40 of about 356,678 (297)

WWOX loss activates aerobic glycolysis [PDF]

Molecular & Cellular Oncology, 2014
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch.
Abu-Remaileh, Muhannad, Seewaldt, Victoria L, Aqeilan, Rami I   +2 more
openaire   +2 more sources

Ion channel Piezo1 activation promotes aerobic glycolysis in macrophages

Frontiers in Immunology, 2022
Altered microenvironmental stiffness is a hallmark of inflammation. It is sensed by the mechanically activated cation channel Piezo1 in macrophages to induce subsequent immune responses.
Shaoqiu Leng, Xiaoyu Zhang, Shuwen Wang, J. Qin, Qiang Liu, Anli Liu, Zi Sheng, Q. Feng, Xiang Hu, J. Peng   +9 more
semanticscholar   +1 more source

mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma

Theranostics, 2022
Background: Hepatocellular Carcinoma (HCC) is a major form of liver cancer and a leading cause of cancer-related death worldwide. New insights into HCC pathobiology and mechanism of drug actions are urgently needed to improve patient outcomes.
Hong Zhang, Xiaoyang Su, S. Burley, X. S. Zheng   +3 more
semanticscholar   +1 more source

Aerobic glycolysis and lymphocyte transformation [PDF]

Biochemical Journal, 1978
1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-14C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was
Hume, David A., Radik, Judith L., Ferber, Ernst, Weidemann, Maurice J.   +3 more
openaire   +3 more sources

NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma

BMC Cancer, 2021
Background Increased expression of the transcription factor Forkhead box M1 (FOXM1) has been reported to play an important role in the progression and development of multiple tumors, but the molecular mechanisms that regulate FOXM1 expression remain ...
Xiangsheng Su, Yihang Yang, Qing Yang, Bo Pang, Shicheng Sun, Yanjun Wang, Qiujiang Qiao, Changfa Guo, Huanting Liu, Qi Pang   +9 more
doaj   +1 more source

Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy

International Journal of Molecular Medicine, 2021
Metabolism reprogramming influences the severity of organ dysfunction, progression to fibrosis, and development of disease in acute kidney injury (AKI).
Chuyi Tan, Jia Gu, Tao Li, Huan Chen, Ke Liu, Mei-dong Liu, Huali Zhang, Xianzhong Xiao   +7 more
semanticscholar   +1 more source

Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

Journal of experimental & clinical cancer research : CR, 2020
Liver cancer has become the sixth most diagnosed cancer and the fourth leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is responsible for up to 75–85% of primary liver cancers, and sorafenib is the first targeted drug for advanced
Jiao Feng, Jingjing Li, Liwei Wu, Qiang Yu, J. Ji, Jianye Wu, Wei-qi Dai, Chuanyong Guo   +7 more
semanticscholar   +1 more source

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Cell Reports, 2018
Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear.
Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, Claudio Punzo   +6 more
doaj   +1 more source

Development of an Aerobic Glycolysis Index for Predicting the Sorafenib Sensitivity and Prognosis of Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is a deadly tumor with high heterogeneity. Aerobic glycolysis is a common indicator of tumor growth and plays a key role in tumorigenesis.
Yu Pan, Yu Pan, Yu Pan, Yu Pan, Yu Pan, Yu Pan, Geng-yuan Hu, Geng-yuan Hu, Geng-yuan Hu, Shi Jiang, Shi Jiang, Shi Jiang, Shi Jiang, Shi Jiang, Shi Jiang, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Hendi Maher, Hendi Maher, Hendi Maher, Hendi Maher, Hendi Maher, Hendi Maher, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Jie Zhao, Jie Zhao, Jie Zhao, Jie Zhao, Jie Zhao, Liu-xin Cai, Liu-xin Cai, Liu-xin Cai, Liu-xin Cai, Liu-xin Cai, Ying-hua Xu, Jun-jie Xu, Jun-jie Xu, Jun-jie Xu, Jun-jie Xu, Jun-jie Xu, Xiu-jun Cai, Xiu-jun Cai, Xiu-jun Cai, Xiu-jun Cai, Xiu-jun Cai   +59 more
doaj   +1 more source

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

bioRxiv, 2020
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo, Zhaoqi Li, D. Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, R. Ferreira, Adi Naamati, A. Ali, C. Lewis, Craig J. Thomas, S. Spranger, N. Matheson, M. V. Vander Heiden   +13 more
semanticscholar   +1 more source