Results 31 to 40 of about 339,203 (181)

LncRNA HCG18 promotes osteosarcoma growth by enhanced aerobic glycolysis via the miR-365a-3p/PGK1 axis

Cellular & Molecular Biology Letters, 2022
Background Osteosarcoma (OS) is a common primary bone malignancy. Long noncoding RNA HCG18 is known to play an important role in a variety of cancers. However, its role in OS and relevant molecular mechanisms are unclear.
Xiaohui Pan, Jindong Guo, Canjun Liu, Zhanpeng Pan, Zhicheng Yang, Xiang Yao, Jishan Yuan   +6 more
semanticscholar   +1 more source

Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin

Respiratory Research, 2022
Background Up-regulation of aerobic glycolysis has been reported as a characterization of asthma and facilitates airway inflammation. We has been previously reported that short isoform thymic stromal lymphopoietin (sTSLP) could reduce inflammation in ...
Changhui Yu, Wufeng Huang, Zicong Zhou, Shixiu Liang, Zili Zhou, Jieyi Liu, Haijing Zhao, Laiyu Liu, Hangming Dong, Fei Zou, Shaoxi Cai   +10 more
doaj   +1 more source

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

bioRxiv, 2020
Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is a hallmark of proliferative metabolism that is observed across many organisms and conditions. To better understand why aerobic glycolysis
Alba Luengo, Zhaoqi Li, D. Y. Gui, Lucas B. Sullivan, Maria Zagorulya, Brian T. Do, R. Ferreira, Adi Naamati, A. Ali, C. Lewis, Craig J. Thomas, S. Spranger, N. Matheson, M. V. Vander Heiden   +13 more
semanticscholar   +1 more source

Aerobic glycolysis enhances HBx-initiated hepatocellular carcinogenesis via NF-κBp65/HK2 signalling

Journal of experimental & clinical cancer research : CR, 2022
Background Aerobic glycolysis has been recognized as one of the growth-promoting metabolic alterations of cancer cells. Emerging evidence indicates that nuclear factor κB (NF-κB) plays significant roles in metabolic adaptation in normal cells and cancer ...
Lingjun Chen, Xian-yi Lin, Yiming Lei, Xuan Xu, Qi Zhou, Yan Chen, Huiling Liu, Jie Jiang, Yidong Yang, Feng-ping Zheng, Bin Wu   +10 more
semanticscholar   +1 more source

Long non-coding RNAs play an important regulatory role in tumorigenesis and tumor progression through aerobic glycolysis

Frontiers in Molecular Biosciences, 2022
Compared to normal cells, cancer cells generate ATP mainly through aerobic glycolysis, which promotes tumorigenesis and tumor progression. Long non-coding RNAs (LncRNAs) are a class of transcripts longer than 200 nucleotides with little or without ...
Ni Fan, Hui Fu, Xuchen Feng, Yatong Chen, Jingyu Wang, Yuqi Wu, Yuhong Bian, Yingpeng Li, Yingpeng Li   +8 more
doaj   +1 more source

Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c‐myc/hexokinase 2 pathway

Journal of Cellular and Molecular Medicine, 2022
Aerobic glycolysis is a well‐known hallmark of hepatocellular carcinoma (HCC). Hence, targeting the key enzymes of this pathway is considered a novel approach to HCC treatment. The effects of sodium butyrate (NaBu), a sodium salt of the short‐chain fatty
Qiang Yu, Wei-qi Dai, Jie Ji, Liwei Wu, Jiao Feng, Jingjing Li, Yuanyuan Zheng, Yan Li, Ziqi Cheng, Jie Zhang, Jianye Wu, Xuanfu Xu, Chuanyong Guo   +12 more
semanticscholar   +1 more source

EIF4A3-induced circARHGAP29 promotes aerobic glycolysis in docetaxel-resistant prostate cancer through IGF2BP2/c-Myc/LDHA signaling.

Cancer Research, 2021
Docetaxel-based chemotherapy is a standard-of-care treatment for metastatic prostate cancer (PCa), and chemoresistance remains a major challenge in clinical practice.
Xingkang Jiang, Shanqi Guo, Shuo Wang, Yangyi Zhang, Haojie Chen, Yong Wang, Ranlu Liu, Y. Niu, Yong Xu   +8 more
semanticscholar   +1 more source

CircRPN2 inhibits aerobic glycolysis and metastasis in hepatocellular carcinoma.

Cancer Research, 2022
Although circular RNAs (circRNA) are known to modulate tumor initiation and progression, their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood.
Jia Li, Zhi-qiang Hu, Songyang Yu, Li Mao, Zheng-jun Zhou, Peng-Cheng Wang, Y. Gong, Sheng Su, Jian Zhou, Jia Fan, Shaolai Zhou, Xiaowu Huang   +11 more
semanticscholar   +1 more source

HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification

Cell Death Discovery, 2023
Aerobic glycolysis has been shown to play a key role in tumor cell proliferation and metastasis. However, how it is directly regulated is largely unknown.
Jiayu Wang, Mengxin Zhu, Jinghan Zhu, Juntao Li, Xingchao Zhu, Kun Wang, Kanger Shen, Kexi Yang, Xiangyu Ni, Xin Liu, Guangbo Zhang, Qinhua Xi, Tongguo Shi, Weichang Chen   +13 more
doaj   +1 more source

Advances in the study of aerobic glycolytic effects in resistance to radiotherapy in malignant tumors [PDF]

PeerJ, 2023
Aerobic glycolysis is a metabolic mode of tumor cells different from normal cells that plays an important role in tumor proliferation and distant metastasis.
Yuyi Liu, Zhengfu Feng, Pingmei Zhang, Honghao Chen, Song Zhu, Xin Wang   +5 more
doaj   +2 more sources