Results 41 to 50 of about 339,203 (181)

Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer

Advancement of science, 2022
Aerobic glycolysis (Warburg effect), a hallmark of cancer, plays a critical role in cancer cell growth and metastasis; however, direct inhibition of the Warburg effect remains largely unknown.
Xiujuan Zhang, Fei Luo, Shaliu Luo, Ling Li, Xinxin Ren, Jing Lin, Yingchun Liang, Chao Ma, Lihua Ding, Deyu Zhang, Tianxing Ye, Yanni Lin, Bilian Jin, Shan Gao, Q. Ye   +14 more
semanticscholar   +1 more source

Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa

Cell Reports, 2018
Aerobic glycolysis accounts for ∼80%–90% of glucose used by adult photoreceptors (PRs); yet, the importance of aerobic glycolysis for PR function or survival remains unclear.
Lolita Petit, Shan Ma, Joris Cipi, Shun-Yun Cheng, Marina Zieger, Nissim Hay, Claudio Punzo   +6 more
doaj   +1 more source

HOXA3 and KDM6A cooperate in transcriptional control of aerobic glycolysis and glioblastoma progression.

Neuro-Oncology, 2022
BACKGROUND Alterations in transcriptional regulators of glycolytic metabolism have been implicated in brain tumor growth, but the underlying molecular mechanisms remain poorly understand.
Rui Yang, Guanghui Zhang, Z. Dong, S. Wang, Yanping Li, F. Lian, Xiaoran Liu, Haibin Li, Xiaonan Wei, H. Cui   +9 more
semanticscholar   +1 more source

NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma

BMC Cancer, 2021
Background Increased expression of the transcription factor Forkhead box M1 (FOXM1) has been reported to play an important role in the progression and development of multiple tumors, but the molecular mechanisms that regulate FOXM1 expression remain ...
Xiangsheng Su, Yihang Yang, Qing Yang, Bo Pang, Shicheng Sun, Yanjun Wang, Qiujiang Qiao, Changfa Guo, Huanting Liu, Qi Pang   +9 more
doaj   +1 more source

Development of an Aerobic Glycolysis Index for Predicting the Sorafenib Sensitivity and Prognosis of Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Hepatocellular carcinoma (HCC) is a deadly tumor with high heterogeneity. Aerobic glycolysis is a common indicator of tumor growth and plays a key role in tumorigenesis.
Yu Pan, Yu Pan, Yu Pan, Yu Pan, Yu Pan, Yu Pan, Geng-yuan Hu, Geng-yuan Hu, Geng-yuan Hu, Shi Jiang, Shi Jiang, Shi Jiang, Shi Jiang, Shi Jiang, Shi Jiang, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Shun-jie Xia, Hendi Maher, Hendi Maher, Hendi Maher, Hendi Maher, Hendi Maher, Hendi Maher, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Zhong-jie Lin, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Qi-jiang Mao, Jie Zhao, Jie Zhao, Jie Zhao, Jie Zhao, Jie Zhao, Liu-xin Cai, Liu-xin Cai, Liu-xin Cai, Liu-xin Cai, Liu-xin Cai, Ying-hua Xu, Jun-jie Xu, Jun-jie Xu, Jun-jie Xu, Jun-jie Xu, Jun-jie Xu, Xiu-jun Cai, Xiu-jun Cai, Xiu-jun Cai, Xiu-jun Cai, Xiu-jun Cai   +59 more
doaj   +1 more source

Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy

International Journal of Molecular Medicine, 2021
Metabolism reprogramming influences the severity of organ dysfunction, progression to fibrosis, and development of disease in acute kidney injury (AKI).
Chuyi Tan, Jia Gu, Tao Li, Huan Chen, Ke Liu, Mei-dong Liu, Huali Zhang, Xianzhong Xiao   +7 more
semanticscholar   +1 more source

Quercetin Antagonizes Glucose Fluctuation Induced Renal Injury by Inhibiting Aerobic Glycolysis via HIF-1α/miR-210/ISCU/FeS Pathway

Frontiers in Medicine, 2021
Background and Objective: Glucose fluctuation (GF) has been reported to induce renal injury and diabetic nephropathy (DN). However, the mechanism still remains ambiguous.
Wei-long Xu, Su Liu, Nan Li, Li-fang Ye, Min Zha, Chang-yin Li, Yue Zhao, Qiang Pu, Jin-jing Bao, Xing-jie Chen, Jiang-yi Yu, Ying-hao Pei   +11 more
doaj   +1 more source

The fatty acid receptor CD36 promotes HCC progression through activating Src/PI3K/AKT axis-dependent aerobic glycolysis

Cell Death and Disease, 2021
Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both lipid and glucose metabolism in the liver.
Xiaoqing Luo, Enze Zheng, Li Wei, H. Zeng, H. Qin, Xiaoyu Zhang, Meng Liao, Lin Chen, Lei Zhao, X. Ruan, Ping Yang, Yaxi Chen   +11 more
semanticscholar   +1 more source

The therapeutic implications of immunosuppressive tumor aerobic glycolysis

Cellular & Molecular Immunology, 2021
In 2011, Hanahan and Weinberg added “Deregulating Cellular Energetics” and “Avoiding Immune Destruction” to the six previous hallmarks of cancer. Since this seminal paper, there has been a growing consensus that these new hallmarks are not mutually ...
Bradley I. Reinfeld, W. Rathmell, Tae Kon Kim, J. Rathmell   +3 more
semanticscholar   +1 more source

MicroRNA-16-1-3p Represses Breast Tumor Growth and Metastasis by Inhibiting PGK1-Mediated Warburg Effect

Frontiers in Cell and Developmental Biology, 2020
The Warburg effect (aerobic glycolysis) is a hallmark of cancer and is becoming a promising target for diagnosis and therapy. Phosphoglycerate kinase 1 (PGK1) is the first adenosine triphosphate (ATP)-generating glycolytic enzyme in the aerobic ...
Tianxing Ye, Tianxing Ye, Yingchun Liang, Deyu Zhang, Xuewu Zhang   +4 more
doaj   +1 more source