Results 41 to 50 of about 356,678 (297)
Frontiers in Medicine, 2021 Background and Objective: Glucose fluctuation (GF) has been reported to induce renal injury and diabetic nephropathy (DN). However, the mechanism still remains ambiguous.
Wei-long Xu +11 more
doaj +1 more source
Advances in the study of aerobic glycolytic effects in resistance to radiotherapy in malignant tumors [PDF]
PeerJ, 2023 Aerobic glycolysis is a metabolic mode of tumor cells different from normal cells that plays an important role in tumor proliferation and distant metastasis.
Yuyi Liu +5 more
doaj +2 more sources
Science Signaling, 2021 Kidney tumors lacking fumarate hydratase become aggressive due to a metabolic shift arising from altered mitochondrial DNA. A metabolic shift from altered mitochondrial DNA Deficiency in the metabolic enzyme fumarate hydratase distinguishes an aggressive
D. Crooks +26 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both lipid and glucose metabolism in the liver.
Xiaoqing Luo +11 more
semanticscholar +1 more source
Aerobic glycolysis, motility, and cytoskeletal remodeling [PDF]
Cell Cycle, 2014 Cancer cell motility and cytoskeletal remodeling are ubiquitous processes essential in cancer progression to metastasis. The role of metabolism in driving motility processes and cytoskeletal rearrangements is not fully understood, but abnormal usage of cellular energetics is a well-documented hallmark of cancer.1 Shiraishi and colleagues now provide ...
Verdone, James E +2 more
openaire +2 more sources
Journal of Cellular and Molecular Medicine, 2022 Aerobic glycolysis is a well‐known hallmark of hepatocellular carcinoma (HCC). Hence, targeting the key enzymes of this pathway is considered a novel approach to HCC treatment. The effects of sodium butyrate (NaBu), a sodium salt of the short‐chain fatty
Qiang Yu +12 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2020 The Warburg effect (aerobic glycolysis) is a hallmark of cancer and is becoming a promising target for diagnosis and therapy. Phosphoglycerate kinase 1 (PGK1) is the first adenosine triphosphate (ATP)-generating glycolytic enzyme in the aerobic ...
Tianxing Ye +4 more
doaj +1 more source
CircRPN2 inhibits aerobic glycolysis and metastasis in hepatocellular carcinoma.
Cancer Research, 2022 Although circular RNAs (circRNA) are known to modulate tumor initiation and progression, their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood.
Jia Li +11 more
semanticscholar +1 more source
Molecular Therapy: Oncolytics, 2020 Targeting metabolic reprogramming is an emerging strategy in cancer therapy. However, clinical attempts to target metabolic reprogramming have been proved to be challenging, with metabolic heterogeneity of cancer being one of many reasons that causes ...
Ting-Chun Kuo +10 more
doaj +1 more source
Stem cell research & therapeutics, 2022 Background Mitofusin-2 ( MFN2 ) is a kind of GTPase that participates in the regulation of mitochondrial fusion, which is related to a variety of physiological and pathological processes, including energy metabolism, cell differentiation, and embryonic ...
Lidi Deng +4 more
semanticscholar +1 more source