Results 71 to 80 of about 339,203 (181)

Notch1/TAZ axis promotes aerobic glycolysis and immune escape in lung cancer

Cell Death and Disease, 2021
Oncogenic signaling pathway reprograms cancer cell metabolism to promote aerobic glycolysis in favor of tumor growth. The ability of cancer cells to evade immunosurveillance and the role of metabolic regulators in T-cell functions suggest that oncogene ...
M. Xie, Xinge Fu, K. Jiang
semanticscholar   +1 more source

Warburg effect and lactylation in cancer: mechanisms for chemoresistance

Molecular Medicine
In the clinical management of cancers, the emergence of chemoresistance represents a profound and imperative “pain point” that requires immediate attention. Understanding the mechanisms of chemoresistance is essential for developing effective therapeutic
Wenjie Zhang, Min Xia, Jiahui Li, Gaohua Liu, Yan Sun, Xisha Chen, Jing Zhong   +6 more
doaj   +1 more source

Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer

Frontiers in Pharmacology, 2019
Aerobic glycolysis plays a decisive role in cancer growth. However, its role in cancer metastasis was rarely understood. Cantharidin a natural compound from an arthropod insect cantharis exerts potent anticancer activity.
Yanhong Pan, Qian Zheng, Wenting Ni, Zhonghong Wei, Suyun Yu, Qi Jia, Meng Wang, Aiyun Wang, Wenxing Chen, Wenxing Chen, Yin Lu, Yin Lu   +11 more
doaj   +1 more source

GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

Frontiers in Oncology, 2020
Self-sustained cell proliferation constitutes one hallmark of cancer enabled by aerobic glycolysis which is characterized by imbalanced glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) activity, named the Warburg effect.
Annika Sünderhauf, Annika Raschdorf, Maren Hicken, Heidi Schlichting, Franziska Fetzer, Ann-Kathrin Brethack, Sven Perner, Sven Perner, Claudia Kemper, Claudia Kemper, Claudia Kemper, Berhane Ghebrehiwet, Christian Sina, Christian Sina, Stefanie Derer   +14 more
doaj   +1 more source

Stiffer Matrix Accelerates Migration of Hepatocellular Carcinoma Cells through Enhanced Aerobic Glycolysis Via the MAPK-YAP Signaling

Cancers, 2020
Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells are two fundamental mediators of tumor progression, including hepatocellular carcinoma (HCC).
Qiuping Liu, Qing Luo, Bin Deng, Y. Ju, Guanbin Song   +4 more
semanticscholar   +1 more source

Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2

Nature Communications, 2020
Interacting with proteins is a crucial way for long noncoding RNAs (lncRNAs) to exert their biological responses. Here we report a high throughput strategy to characterize lncRNA interacting proteins in vivo by combining tobramycin affinity purification ...
Chunqing Wang, Yongmei Li, Shuai Yan, Hao Wang, Xianfeng Shao, M. Xiao, Baicai Yang, Guoxuan Qin, R. Kong, Ruibing Chen, Ning Zhang   +10 more
semanticscholar   +1 more source

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Cancer Management and Research, 2021
Peng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu, Linjiang Song Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s ...
Huang P, Zhu S, Liang X, Zhang Q, Luo X, Liu C, Song L   +6 more
doaj  

RETRACTED ARTICLE: The miR-30a-5p/CLCF1 axis regulates sorafenib resistance and aerobic glycolysis in hepatocellular carcinoma

Cell Death and Disease, 2020
HCC (hepatocellular carcinoma) is a major health threat for the Chinese population and has poor prognosis because of strong resistance to chemotherapy in patients.
Zhongqiang Zhang, Xiaolang Tan, Jing Luo, H. Yao, Z. Si, Jingshan Tong   +5 more
semanticscholar   +1 more source

Modularity of the metabolic gene network as a prognostic biomarker for hepatocellular carcinoma [PDF]

arXiv, 2017
Abnormal metabolism is an emerging hallmark of cancer. Cancer cells utilize both aerobic glycolysis and oxidative phosphorylation (OXPHOS) for energy production and biomass synthesis. Understanding the metabolic reprogramming in cancer can help design therapies to target metabolism and thereby to improve prognosis.
arxiv  

Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Proceedings of the National Academy of Sciences of the United States of America, 1994
Glutamate, released at a majority of excitatory synapses in the central nervous system, depolarizes neurons by acting at specific receptors. Its action is terminated by removal from the synaptic cleft mostly via Na(+)-dependent uptake systems located on ...
L. Pellerin, P. Magistretti
semanticscholar   +1 more source