Results 51 to 60 of about 2,414,823 (352)
Epidemiology of Dog and Cat Abandonment in Spain (2008–2013)
Animals, 2015 Millions of pets are abandoned worldwide every year, which is an important animal welfare and financial problem. This paper was divided into three studies.
Jaume Fatjó +6 more
doaj +1 more source
Applied Sciences, 2023 Understanding the patterns of noncovalent adsorption of double-stranded nucleic acids (dsDNA) on gold nanoparticles (GNPs) was the aim of this study. It was found that the high-affinity motifs in DNA can and do act as an “anchor” for the fixation of the ...
Ekaterina A. Gorbunova +3 more
doaj +1 more source
Affinity Weighted Embedding [PDF]
, 2013 Supervised (linear) embedding models like Wsabie and PSI have proven successful at ranking, recommendation and annotation tasks. However, despite being scalable to large datasets they do not take full advantage of the extra data due to their linear ...
Weiss, Ron, Weston, Jason, Yee, Hector
core
Clustering via kernel decomposition [PDF]
, 2006 Spectral clustering methods were proposed recently which rely on the eigenvalue decomposition of an affinity matrix. In this letter, the affinity matrix is created from the elements of a nonparametric density estimator and then decomposed to obtain ...
Girolami, M. +2 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Current applications of antibody microarrays
Clinical Proteomics, 2018 The concept of antibody microarrays is one of the most versatile approaches within multiplexed immunoassay technologies. These types of arrays have increasingly become an attractive tool for the exploratory detection and study of protein abundance ...
Ziqing Chen +3 more
doaj +1 more source
Impact of peptide:HLA complex stability for the identification of SARS-CoV-2-specific CD8+T cells
Frontiers in Immunology, 2023 Induction of a lasting protective immune response is dependent on presentation of epitopes to patrolling T cells through the HLA complex. While peptide:HLA (pHLA) complex affinity alone is widely exploited for epitope selection, we demonstrate that ...
Olivia Lie-Andersen +13 more
doaj +1 more source
Effect of thiols on beta 2-adrenoceptors in human mononuclear leucocytes [PDF]
, 1988 The effect of the disulfide reducing agent dithiothreitol (DTT) and other thiols on binding of the beta-adrenoceptor antagonist (-)-125iodocyanopindolol (125ICYP) to human mononuclear leucocytes (MNL) was investigated.
Anhäupl, T. +3 more
core
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Bio-Layer Interferometry Analysis of the Target Binding Activity of CRISPR-Cas Effector Complexes
Frontiers in Molecular Biosciences, 2020 CRISPR-Cas systems employ ribonucleoprotein complexes to identify nucleic acid targets with complementarity to bound CRISPR RNAs. Analyses of the high diversification of these effector complexes suggest that they can exhibit a wide spectrum of target ...
Hanna Müller-Esparza +8 more
doaj +1 more source