Results 51 to 60 of about 2,425,944 (351)

α_1L-adrenoceptors mediate contraction of human erectile tissue [PDF]

, 2018
α1-adrenoceptor antagonists can impact upon sexual function and have potential in the treatment of erectile dysfunction. Human erectile tissue contains predominantly α1A-adrenoceptors, and here we examined whether contractions of this tissue are mediated
Campbell, Alistair, Chapple, Christopher R., Chess-Williams, Russ, Davis, Beverley J., Naylor, Alisdair L., Sellers, Donna J., Sillar, David   +6 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Dietary Inulin Supplementation Modulates Fecal Microbiota and Vaccine Response in Cats—A Double-Blind Randomized Controlled Pilot Study

Pets
Twenty-six cats were fed either a control or an inulin-supplemented diet (0.6%) for six weeks with measurements of fecal short-chain fatty acids (SCFAs) and microbiota.
Isabelle C. Jeusette, Emmanuelle Apper, Marina L. Meli, Regina Hofmann-Lehmann, Anna Salas-Mani, Anna Fernández-Pinteño, Olga Francino, Celina Torre   +7 more
doaj   +1 more source

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy

mAbs, 2022
Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibodies
Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup   +7 more
doaj   +1 more source

HELIN Cataloging Policies and Procedures Manual [PDF]

, 2011
HELIN Cataloging Manual - Nov.
HELIN Consortium. Cataloging Affinity Group
core   +1 more source

One Complete and Seven Draft Genome Sequences of Subdivision 1 and 3 Acidobacteria Isolated from Soil. [PDF]

, 2020
We report eight genomes from representatives of the phylum Acidobacteria subdivisions 1 and 3, isolated from soils. The genome sizes range from 4.9 to 6.7 Mb.
Clum, Alicia, Daum, Chris, Eichorst, Stephanie A, Goodwin, Lynne A, Huntemann, Marcel, Ivanova, Natalia, Kyrpides, Nikos, Mikhailova, Natalia, Palaniappan, Krishnaveni, Pillay, Manoj, Reddy, TBK, Shapiro, Nicole, Stamatis, Dimitrios, Trojan, Daniela, Varghese, Neha, Woebken, Dagmar, Woyke, Tanja   +16 more
core  

Carbon nanotube decorated magnetic microspheres as an affinity matrix for biomolecules [PDF]

, 2013
Carbon nanotube (CNT) decorated magnetic microspheres were fabricated to develop a multimodal platform that utilizes non-covalent molecular interactions of CNTs to magnetically separate biomolecules.
Kolkar Mohammed, Javed Hussain Niazi, Ünal, Hayriye   +1 more
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex

Frontiers in Neuroscience, 2015
Traditionally myelin is viewed as insulation around axons however more recent studies have shown it plays an important role in plasticity, axonal metabolism and neuroimmune signalling.
Caitlin R Siu, Justin L Balsor, David G Jones, Kathryn M Murphy, Kathryn M Murphy   +4 more
doaj   +1 more source

Structural and Functional Aspects of G-Quadruplex Aptamers Which Bind a Broad Range of Influenza A Viruses

Biomolecules, 2020
An aptamer is a synthetic oligonucleotide with a unique spatial structure that provides specific binding to a target. To date, several aptamers to hemagglutinin of the influenza A virus have been described, which vary in affinity and strain specificity ...
Anastasia A. Novoseltseva, Nikita M. Ivanov, Roman A. Novikov, Yaroslav V. Tkachev, Dmitry A. Bunin, Alexandra S. Gambaryan, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov, Elena G. Zavyalova   +9 more
doaj   +1 more source