Results 81 to 90 of about 2,425,944 (351)

Proof of concept of using a membrane-sensing peptide for sEVs affinity-based isolation

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: One main limitation in biomarker studies using EVs is the lack of a suitable isolation method rendering high yield and purity samples in a quick and easily standardized procedure.
Beatriz Benayas, Beatriz Benayas, Joaquín Morales, Alessandro Gori, Alessandro Strada, Paola Gagni, Roberto Frigerio, Carolina Egea, Pilar Armisén, Marina Cretich, María Yáñez-Mó   +10 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

APPLICATION OF REVERSE MOLECULAR DOCKING FOR THE IDENTIFICATION OF PROTEIN TARGETS OF S-ETHYLTHIOSULFANYLATE INVOLVED IN BIOSURFACTANT BIOSYNTHESIS [PDF]

Biotechnologia Acta
Aim. The study is focused on determining the effect of the ligand S-ethylthiosulfanylate on protein targets involved in the synthesis of biosurfactants and evaluating their potential interaction. Materials and Methods.
Yanvarov Y.B., Havryliak V.V.
doaj   +1 more source

Antibody-antigen interactions: What is the required time to equilibrium? [PDF]

, 2010
The use of antibodies is widespread in many areas including in-vivo and in-vitro diagnostics, quantitative analysis in research laboratories and as therapeutic substances.
Hanna Bjö, Karl Andersson, Magnus Malmqvist   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Fluorescent Probes for Insect Ryanodine Receptors: Candidate Anthranilic Diamides

Molecules, 2014
Diamide insecticides with high efficacy against pests and good environmental safety are broadly applied in crop protection. They act at a poorly-defined site in the very complex ryanodine (Ry) receptor (RyR) potentially accessible to a fluorescent probe.
Yi Wang, Lei Guo, Suzhen Qi, Hao Zhang, Kechang Liu, Ruiquan Liu, Pei Liang, John E. Casida, Shangzhong Liu   +8 more
doaj   +1 more source

Affine grassmannians

Journal of Combinatorial Theory, Series A, 1995
Let \({\mathbf P \mathbf G}(V)\) be an \((n + 1)\)-dimensional projective space arising from a right \((n + 2)\)-dimensional vector space over some skewfield \(D\). Let \(0 \leq k \leq n\) and let \({\mathcal H}\) be a collection of \(k\)-dimensional subspaces of \({\mathbf P \mathbf G} (V)\) with the property that for every \((k-1)\)-dimensional ...
openaire   +2 more sources

Feminist scholarship, bridge-building and political affinity [PDF]

, 2009
In this short essay we consider, first, the reasons why feminist IR academics should seek to build bridges with each other, with other academics and with those outside the university.
Eschle, C., Maiguashca, Bice
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19

Nature Communications
Autoantibodies have been shown to be implied in COVID-19 but the emerging autoantibody repertoire remains largely unexplored. We investigated the new-onset autoantibody repertoire in 525 healthcare workers and hospitalized COVID-19 patients at five time ...
August F. Jernbom, Lovisa Skoglund, Elisa Pin, Ronald Sjöberg, Hanna Tegel, Sophia Hober, Elham Rostami, Annica Rasmusson, Janet L. Cunningham, Sebastian Havervall, Charlotte Thålin, Anna Månberg, Peter Nilsson   +12 more
doaj   +1 more source