Results 21 to 30 of about 733,038 (191)

Controlling uncertainty in aptamer selection [PDF]

, 2016
The search for high-affinity aptamers for targets such as proteins, small molecules, or cancer cells remains a formidable endeavor. Systematic Evolution of Ligands by EXponential Enrichment (SELEX) offers an iterative process to discover these aptamers ...
Desai, Darash, Ho, Nga, Irani Shemirani, Atena, Spill, Fabian, Weinstein, Zohar B., Zaman, Muhammad H.   +5 more
core   +2 more sources

A Population Dynamics Model for Clonal Diversity in a Germinal Center

Frontiers in Microbiology, 2017
Germinal centers (GCs) are micro-domains where B cells mature to develop high affinity antibodies. Inside a GC, B cells compete for antigen and T cell help, and the successful ones continue to evolve.
Assaf Amitai, Assaf Amitai, Assaf Amitai, Luka Mesin, Gabriel D. Victora, Mehran Kardar, Arup K. Chakraborty, Arup K. Chakraborty, Arup K. Chakraborty, Arup K. Chakraborty   +9 more
doaj   +1 more source

Improved Clonal Selection Algorithm Based on Biological Forgetting Mechanism

Complexity, 2020
The antibody candidate set generated by the clonal selection algorithm has only a small number of antibodies with high antigen affinity to obtain high-frequency mutations.
Chao Yang, Bing-qiu Chen, Lin Jia, Hai-yang Wen   +3 more
doaj   +1 more source

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase [PDF]

, 2017
During antibody affinity maturation, germinal center (GC) B cells cycle between affinity-driven selection in the light zone (LZ) and proliferation and somatic hypermutation in the dark zone (DZ).
Dominguez-Sola, David, Efeyan, Alejo, Ersching, Jonatan, Grabiner, Brian C., Jacobsen, Johanne T., Mesin, Luka, Pasqual, Giulia, Sabatini, David, Victora, Gabriel D.   +8 more
core   +1 more source

Structural basis of IL-23 antagonism by an Alphabody protein scaffold [PDF]

, 2014
Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics.
Bloch, Yehudi, Deroo, Sabrina, Desmet, Johan, Devreese, Bart, Henderikx, Paula, Hettmann, Thore, Lasters, Ignace, Lorent, Eric, Loverix, Stefan, Savvides, Savvas, Somers, Klaartje, Vandenbroucke, Karen, Verstraete, Kenneth, Wen, Yurong   +13 more
core   +1 more source

A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection

iScience, 2023
Summary: Developing CD4+CD8+ double-positive (DP) thymocytes with randomly generated T cell receptors (TCRs) undergo positive (maturation) or negative (apoptosis) selection on the basis of the strength of TCR stimulation.
Shintaro Funasaki, Atsushi Hatano, Hirokazu Nakatsumi, Daisuke Koga, Osamu Sugahara, Kanae Yumimoto, Masaya Baba, Masaki Matsumoto, Keiichi I. Nakayama   +8 more
doaj   +1 more source

Improving Pharmacokinetics of Peptides Using Phage Display

Viruses
Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel ...
Mallika Asar, Jessica Newton-Northup, Mette Soendergaard   +2 more
doaj   +1 more source

A mechanism of T cell dependent selection of antigen engaged Germinal Center B cells. [PDF]

PLoS ONE, 2018
A model of B cell affinity selection is proposed, and an explanation of peripheral tolerance mechanisms through antibody repertoire editing is presented.
Vinod Krishna, Kurtis E Bachman
doaj   +1 more source

Amount of antigen, T follicular helper cells and affinity of founder cells shape the diversity of germinal center B cells: A computational study

Frontiers in Immunology, 2023
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones ...
Amar K. Garg, Tanmay Mitra, Marta Schips, Arnab Bandyopadhyay, Michael Meyer-Hermann, Michael Meyer-Hermann   +5 more
doaj   +1 more source

Learning a Robust Local Manifold Representation for Hyperspectral Dimensionality Reduction

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2017
Local manifold learning has been successfully applied to hyperspectral dimensionality reduction in order to embed nonlinear and nonconvex manifolds in the data.
Danfeng Hong, Naoto Yokoya, Xiao Xiang Zhu   +2 more
doaj   +1 more source