TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Estimating the risk of aflatoxin-induced liver cancer in Tanzania based on biomarker data.
PLoS ONE, 2021 Evidence about the magnitude of the aflatoxin menace can help policy makers appreciate the importance of the problem and strengthen policies to support aflatoxin mitigation measures. In this study, we estimated aflatoxin-induced liver cancer risk in 2016
Martin E Kimanya +5 more
doaj +1 more source
Reducing child undernutrition through dietary diversification, reduced aflatoxin exposure, and improved hygiene practices: the immediate impacts in central Tanzania [PDF]
, 2020 Open Access Article; Published online: 28 Nov 2019The study aimed to quantify the immediate effects of dietary diversification, food safety, and hygiene interventions on child undernutrition in four rural villages in Kongwa district of central Tanzania ...
Anitha, S. +11 more
core +1 more source
, 2022 The aflatoxin producing fungi Aspergillus flavus, A. parasiticus, and A. nomius, although they are also produced by other species of Aspergillus as well as by Emericella spp.(Telemorph). There are many types of aflatoxins, but the four main ones are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1), and aflatoxin G2 (AFG2, while aflatoxin ...
A., Ramadan, Nadeem, A., -eri, Hadeel
openaire +3 more sources
Crop Journal, 2018 Simple sequence repeats (SSRs) are important molecular markers for assessing genetic diversity in Arachis hypogaea L. and many other crops and constructing genetic linkage maps for important agricultural traits.
Houmiao Wang +9 more
doaj +1 more source
Dietary aflatoxin exposure of lactating mothers of children 0–6 months in Makueni County, Kenya
Maternal and Child Nutrition, 2023 The southeastern region of Kenya is prone to aflatoxin outbreaks, yet maternal and infant aflatoxin intake levels remain unclear. We determined dietary aflatoxin exposure of 170 lactating mothers breastfeeding children aged 6 months and below in a ...
Isaac O. Ogallo +3 more
doaj +1 more source
Complex regulation of the aflatoxin biosynthesis gene cluster of Aspergillus flavus in relation to various combinations of water activity and temperature [PDF]
, 2009 A microarray analysis was performed to study the effect of varying combinations of water activity and temperature on the activation of aflatoxin biosynthesis genes in Aspergillus flavus grown on YES medium. Generally A.
Abdel-Hadi, Ahmed +3 more
core +1 more source
Determination of aflatoxin level in peanut using immunoaffinity column combined with ELISA
Environment Conservation Journal, 2011 Peanut (Arachis hypogaea L.) is a largest source of edible oil in India, extensively consumed in the central and western parts of the country. The variability in the total aflatoxin and aflatoxin B1 levels in the different peanut samples collected was ...
Harish Chandra +4 more
doaj +1 more source
BMC Veterinary Research, 2022 Background The adverse effect of aflatoxin in broilers is well known. However, dietary supplementation of Saccharomyces cell wall and/or Nanocurcumin may decrease the negative effect of aflatoxin B1 because of the bio-adsorbing feature of the functional ...
Aya Ashry +6 more
doaj +1 more source
Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation [PDF]
, 2011 Mycotoxins are secondary metabolites present worldwide in agricultural commodities and produced by filamentous fungi that cause a toxic response (mycotoxicosis) when ingested by animals.
Guyonvarc’h, Alain +4 more
core +2 more sources