Results 81 to 90 of about 7,503 (205)

Evaluation of platelet function in essential thrombocythemia under different analytical conditions

Platelets, 2020
Background. Studies of platelet aggregation (PA) in essential thrombocythemia (ET) reported contrasting results, likely due to differences in analytical conditions. Objective. We investigated platelet aggregation using different techniques and analytical
Federico Lussana, Eti Alessandra Femia, Mariateresa Pugliano, Gianmarco Podda, Cristina Razzari, Norma Maugeri, Anna Lecchi, Sabrina Caberlon, Giancarla Gerli, Marco Cattaneo   +9 more
doaj   +1 more source

Perioperative changes of response to antiplatelet medication in vascular surgery patients.

PLoS ONE, 2020
IntroductionReduced antiplatelet activity of aspirin (ALR) or clopidogrel (CLR) is associated with an increased risk of thromboembolic events. The reported prevalence data for low-responders vary widely and there have been few investigations in vascular ...
Thomas Hummel, Saskia Hannah Meves, Andreas Breuer-Kaiser, Jan-Ole Düsterwald, Dominic Mühlberger, Achim Mumme, Horst Neubauer   +6 more
doaj   +1 more source

In vitro effect of Altered Platelet Count on Multiple Electrode Impedance Aggregometry in Dogs [PDF]

, 2017
The objective of this study was to assess platelet aggregation by impedance aggregometry using canine whole blood with adjusted platelet counts. Citrated venous samples from 24 healthy dogs were aliquoted into unmanipulated and manipulated fractions with
Nash, Katherine Jane
core  

Relationships between optical aggregometry (type Born) and flow cytometry in evaluating ADP-induced platelet activation [PDF]

, 2008
Background: Platelet response to activating agents is used to monitor the efficacy of anti-aggregation therapies. The aim of our study has been to demonstrate the existence of relationships between early events of ADP-induced platelet activation ...
De Filippis, Rossella, Buffa, Manuela, Della Pina, Francesca, Rizza, Antonio, Clerico, Aldo, Gianetti, Jacopo, Sbrana, Silverio   +6 more
core   +1 more source

Clopidogrel anti-platelet effect: An evaluation by optical aggregometry, impedance aggregometry, and the Platelet Function Analyzer (PFA-100™)

Platelets, 2007
Platelet aggregation inhibition by clopidogrel may be suboptimal in 4-30% of patients. Traditionally, optical aggregometry is used to assess clopidogrel's anti-platelet effects by inhibition of ADP-induced aggregation in platelet rich plasma. Red blood cells are an important source of ADP and, thus, are known to modulate platelet function.
Anna, Dyszkiewicz-Korpanty, Horatiu, Olteanu, Eugene P, Frenkel, Ravindra, Sarode   +3 more
openaire   +2 more sources

Dasatinib inhibits coated-platelet generation in patients with chronic myeloid leukemia

Platelets, 2019
Since the introduction of tyrosine kinase inhibitors, the overall survival of patients with chronic myeloid leukemia has markedly improved. However long term use of these drugs results in various adverse events. Treatment with second generation dasatinib
Gabriella Mezei, Ildiko Beke Debreceni, Adrienne Kerenyi, Gyula Remenyi, Robert Szasz, Arpad Illes, Janos Kappelmayer, Peter Batar   +7 more
doaj   +1 more source

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients

Brazilian Journal of Medical and Biological Research
Clopidogrel and aspirin are the most commonly used medications worldwide for dual antiplatelet therapy after percutaneous coronary intervention. However, clopidogrel hyporesponsiveness related to gene polymorphisms is a concern.
J.F.M. Marchini, M.R. Pinto, G.C. Novaes, A.V. Badran, R.B. Pavão, G.L. Figueiredo, I.M. Lago, M.O. Lima-Filho, D.C. Lemos, M. Tonani, C.M. Antloga, L. Oliveira, J.C. Lorenzi, J.A. Marin-Neto   +13 more
doaj   +1 more source

Comparison of platelet aggregometry measurements in different pathological groups and healthy control.

, 2014
Platelet aggregation measurements induced by ADP, ASPI and Collagen agonists are shown in the different pathological groups and healthy control. Aggregometry measurements are expressed as area under the curve (AUC, arbitrary units).
Dafydd Thomas (118889), Ceri Battle (532277), Simon Davidson (637044), Gareth R. Davies (637040), Keith Morris (64015), Gavin M. Mills (637041), Matthew Lawrence (472874), Karl Hawkins (637042), Phillip Adrian Evans (637045), Phylip Rhodri Williams (637043)   +9 more
core   +1 more source

Platelet aggregation response to cyclooxygenase inhibition and thromboxane receptor antagonism using impedance aggregometry: A pilot study

Physiological Reports
Impedance aggregometry is an alternative to light transmission aggregometry that allows analysis of platelet function in whole blood samples. We hypothesized (1) impedance aggregometry would produce repeatable results, (2) inhibition of cyclooxygenase ...
Auni C. Williams, Kat G. Fisher, Lacy M. Alexander, W. Larry Kenney   +3 more
doaj   +1 more source

Simple and accessible screening method for congenital thrombopathies using an impedance haematology counter – reply: The differences between impedance aggregometry in whole blood versus aggregometry in PRP. Is there a need for caution?

, 2014
Brahimi et al. in this journal formed a hypothesis that “the platelet count is underestimated, by an automated cell counter, each time platelet aggregates are present in the sample tube.” The addition of a platelet agonist to a stimulated sample tube ...
Kubisz, Peter, Skornova, Ingrid, Ocenasova, Amalia, Stasko, Jan   +3 more
core   +1 more source