Results 21 to 30 of about 211,860 (282)
PLoS ONE, 2014 Lymphopenia-induced proliferation (LIP), a mechanism to maintain a constant number of T cells in circulation, occurs in both normal aging and autoimmune disease.
Ting-Ting Sheu +3 more
doaj +1 more source
Premature aging and immune senescence in HIV-infected children [PDF]
, 2016 Objective: Several pieces of evidence indicate that HIV-infected adults undergo premature aging. The effect of HIV and antiretroviral therapy (ART) exposure on the aging process of HIV-infected children may be more deleterious since their immune system ...
Cam\uf3s, Mireia +11 more
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PREMATURE AGING MARKERS IN WOMEN OF REPRODUCTIVE AGE WITH HYPOPITUITARISM
Alʹmanah Kliničeskoj Mediciny, 2016 Background: Premature aging reduces quality of human life, leads to development of “old age diseases” in younger age, and also shortens life expectancy.
D. S. Mikhaylova, I. A. Ilovayskaya
doaj +1 more source
Vascular fibrosis in aging and hypertension: molecular mechanisms and clinical implications [PDF]
, 2016 Aging is the primary risk factor underlying hypertension and incident cardiovascular disease. With aging, the vasculature undergoes structural and functional changes characterized by endothelial dysfunction, wall thickening, reduced distensibility, and ...
Harvey, Adam +4 more
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RETINOPATHY OF PREMATURITY AND MATERNAL AGE [PDF]
Retina, 2010 To determine the risk factors, especially maternal risk factors, associated with the development of retinopathy of prematurity (ROP) in premature babies.A matched case-control study involving premature patients was undertaken retrospectively. The case group consisted of premature babies with the subsequent development of ROP.
Jane Zea-Chin Kuo +8 more
openaire +3 more sources
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome
Protein & Cell, 2018 Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting in the production of a truncated protein product ...
Zeming Wu +14 more
doaj +1 more source
case report: Werner’s Syndrome [PDF]
, 2013 Werner’s syndrome (WS) is an extremely rare and autosomalrecessive premature aging syndrome characterizedby scleroderma-like skin changes, alopecia, legulcers, short stature, cataract, early atherosclerosis, osteoporosis,hypogonadism and increased ...
Alpaslan Kemal Tuzcu +3 more
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Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome [PDF]
, 2019 Hutchinson–Gilford progeria syndrome (HGPS) is a genetic disorder characterized by premature aging features. Cells from HGPS patients express progerin, a truncated form of Lamin A, which perturbs cellular homeostasis leading to nuclear shape alterations,
Aguado J. +12 more
core +1 more source
Functional relevance of miRNAs in premature ageing [PDF]
Mechanisms of Ageing and Development, 2017 Ageing is a complex biological process characterized by the progressive loss of biological fitness due to the accumulation of macromolecular and cellular damage that affects most living organisms. Moreover, ageing is an important risk factor for many pathologies, including cardiovascular diseases, neurological disorders, and cancer. However, the ageing
Caravia, Xurde M. +3 more
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Lamin A/C, laminopathies and premature ageing. [PDF]
Histology and histopathology, 2008 Lamin A/C belongs to type V intermediate filaments and constitutes the nuclear lamina and nuclear matrix, where a variety of nuclear activities occur. Lamin A/C protein is firstly synthesized as a precursor and is further proteolytically processed by the zinc metallo-proteinase Ste24 (Zmpste24).
Zhou, Z, Liu, B
openaire +4 more sources