An emerging role for agmatine [PDF]
Kidney International, 1999 Polyamines, required components of proliferation, are autoregulated by the protein antizyme. To date, agmatine is the only molecule other than the polyamines that can induce antizyme, and thus influence cell homeostasis and growth. Agmatine has effectively suppressed proliferation in immortalized and transformed cell lines.
Satriano, Joseph +2 more
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Organic Process Research & Development, 2022 Agmatine peptides play a significant role in the therapeutic design. Imparting an agmatine moiety to a peptide molecule through amine amidination with electrophilic guanylating agents could be challenging given the lability of the various nucleophilic ...
Yi Yang, Lena Hansen
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Evaluation of agmatine efficacy in contrast-induced nephropathy: experimental evidence in rat model [PDF]
Acta Cirúrgica BrasileiraPurpose: To investigate the biochemical and histopathological efficacy of agmatine as a protective agent in experimental rat contrast-induced nephropathy (CIN) model. Methods: Twenty-eight male Sprague Dawley rats were randomized into four groups: sham (
Murat Yeniçeri +4 more
doaj +3 more sources
Effect of Agmatine on Acute and Mononeuropathic Pain
Annals of the New York Academy of Sciences, 2003 Abstract: Agmatine is a polycationic amine synthesized from L‐arginine by arginine decarboxylase in brain and several tissues. It binds to N‐methyl‐D‐aspartate (NMDA) subtype of glutamatergic, a2‐adrenergic and imidazoline (I) receptors. The present study was designed to investigate effect of agmatine on acute and mononeuropathic pain after chronic ...
Feyza, Aricioglu +3 more
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Solid-state cultivation-specific agmatine production by Aspergillus oryzae: current understanding and perspectives [PDF]
Amino AcidsAgmatine, a natural polyamine generated from arginine by arginine decarboxylase (ADC), has attracted increasing attention because of its pleiotropic beneficial effects on neuroprotection, lifestyle-related diseases, and gut-brain axis-mediated pathways ...
Naoki Akasaka +3 more
doaj +2 more sources
The effects of agmatine treatment on cisplatin-induced hepatotoxicity: an experimental rat study [PDF]
São Paulo Medical JournalBACKGROUND: Cisplatin is a widely used chemotherapeutic agent whose clinical utility is limited by dose-dependent hepatotoxicity, primarily driven by oxidative stress and inflammation.
Murat Yeniceri +4 more
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The Effects of L-NAME and Agmatine in The Nucleus Accumbens Core Regıon on Morphine Withdrawal Syndrome [PDF]
Namık Kemal Tıp Dergisi, 2020 Aim:The mesocorticolimbic dopaminergic system, especially the nucleus accumbens, is an important region in opioid dependence and withdrawal. Studies have shown that nitric oxide synthase inhibitors modulate the development of tolerance to opioids, opioid
Mahluga JAFAROVA DEMİRKAPU +11 more
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Pharmacology, Medicinal Chemistry, and Therapeutic Potential of Imidazoline Receptor Ligands [PDF]
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Building on the excellent review article by Dardonville and Rozas (2004), this paper summarizes the most representative ligands of imidazoline receptors (IR; I1, I2, and I3) and updates their pharmacological profiles. Although not exhaustive, it provides a solid starting point for understanding the significance of I2 IRs as promising therapeutic ...
Maria‐Eleni Kouridaki +2 more
wiley +2 more sources
The Gene Cluster for Agmatine Catabolism ofEnterococcus faecalis: Study of Recombinant Putrescine Transcarbamylase and Agmatine Deiminase and a Snapshot of Agmatine Deiminase Catalyzing Its Reaction [PDF]
Journal of Bacteriology, 2007 ABSTRACTEnterococcus faecalismakes ATP from agmatine in three steps catalyzed by agmatine deiminase (AgDI), putrescine transcarbamylase (PTC), and carbamate kinase (CK). An antiporter exchanges putrescine for agmatine. We have cloned theE. faecalisef0732 and ef0734 genes of the reported gene cluster for agmatine catabolism, overexpressed them ...
Llácer, José Luis +5 more
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Rhizobacteria‐Induced Systemic Priming Against Fungal Pathogens Involves Hydroxycinnamic Acid Amides [PDF]
Plant, Cell &Environment, Volume 49, Issue 8, Page 4907-4921, August 2026.ABSTRACT The rhizosphere, a narrow region of soil surrounding roots, contains diverse microorganisms with a composition that is distinct from the surrounding soil. Some rhizosphere bacteria can trigger a heightened state of immunity in the whole plant, termed Induced Systemic Resistance (ISR).
Mackenzie Eli William Loranger +5 more
wiley +2 more sources