Results 1 to 10 of about 11,749 (178)

Agouti-related protein as the glucose signaling sensor in the central melanocortin circuits in regulating fish food intake [PDF]

Frontiers in Endocrinology, 2022
Agouti-related protein (AgRP) is a neuropeptide synthesized by AgRP/NPY neurons and transcribed as 132 amino acids in humans and 142 amino acids (AgRP1) in Japanese seabass (Lateolabrax maculatus) fish.
Juan Han, Xiaofang Liang, Yanzhi Guo, Xiaoliang Wu, Ziqi Li, Tiannuo Hong   +5 more
doaj   +2 more sources

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function [PDF]

iScience, 2019
Summary: The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L. Millhauser, Pietro Paolo Sanna   +9 more
doaj   +2 more sources

Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans. [PDF]

J Clin Endocrinol Metab, 2019
AbstractContextGlucocorticoids regulate energy balance, in part by stimulating the orexigenic neuropeptide agouti-related protein (AgRP). AgRP neurons express glucocorticoid receptors, and glucocorticoids have been shown to stimulate AgRP gene expression in rodents.ObjectiveWe sought to determine whether there is a relationship between plasma AgRP and ...
Page-Wilson G, Peters JB, Panigrahi SK, Jacobs TP, Korner J, Otten M, Bruce JN, Wardlaw SL.   +7 more
europepmc   +3 more sources

Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice [PDF]

Acta Neuropathologica Communications
The spectrum of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) and Huntington disease (HD) are fatal neurodegenerative disorders with no major disease-modifying therapies. Recent work has shown that the hallmark pathological proteins TAR
Jennifer Oraha, Ronja Wagner, Sofia Bergh, Nicola J Lee, Deniz Kirik, Åsa Petersén   +5 more
doaj   +2 more sources

Targeted proteomics analysis in type 1 diabetes identifies lower agouti-related protein levels in individuals with impaired hypoglycaemia awareness [PDF]

Scientific Reports
Impaired awareness of hypoglycaemia (IAH) is a complication of diabetes treatment, whereby individuals are no longer able to feel an oncoming hypoglycaemic event.
Rita D. M. Varkevisser, Agnese Petrera, Stefanie M. Hauck, Dick Mul, Henk-Jan Aanstoot, Andrew Paterson, Bruce H. R. Wolffenbuttel, Melanie M. van der Klauw, Dutch Type 1 Diabetes Biomarker Group   +8 more
doaj   +2 more sources

Association of Inflammatory and Cardiovascular Proteomics Biomarkers With Indices of Heart Rate Variability in the General Population: KORA S4/FF4 Study [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We sought to investigate the association between circulating inflammatory and cardiovascular proteomics biomarkers and cardiac autonomic nervous dysfunction–sensitive heart rate variability indices.
Kolade Oluwagbemigun, Dan Ziegler, Alexander Strom, Margit Heier, Gidon Bönhof, Michael Roden, Wolfgang Rathmann, Christa Meisinger, Annette Peters, Stefanie M. Hauck, Agnese Petrera, Moritz F. Sinner, Stefan Kääb, Barbara Thorand, Christian Herder   +14 more
doaj   +2 more sources

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons. [PDF]

Obesity (Silver Spring)
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Minbashi Moeini M, Lavoie O, Caron A, Williams KW, Michael NJ.   +4 more
europepmc   +2 more sources

The role of the Agouti-Related Protein in energy balance regulation. [PDF]

Cell Mol Life Sci, 2008
The Agouti-Related Protein (AgRP) is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally. AgRP-deficiency, on the other hand, leads to increased metabolic rate and a longer lifespan when mice consume a high fat diet.
Ilnytska O, Argyropoulos G.
europepmc   +4 more sources

Integration of Nutrient Sensing in Fish Hypothalamus

Frontiers in Neuroscience, 2021
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid ...
José L. Soengas
doaj   +1 more source

mTORC1 Signaling in AgRP Neurons Is Not Required to Induce Major Neuroendocrine Adaptations to Food Restriction

Cells, 2023
Hypothalamic mTORC1 signaling is involved in nutrient sensing. Neurons that express the agouti-related protein (AgRP) are activated by food restriction and integrate interoceptive and exteroceptive signals to control food intake, energy expenditure, and ...
Gabriel O. de Souza, Pryscila D. S. Teixeira, Niels O. S. Câmara, Jose Donato   +3 more
doaj   +1 more source