Results 91 to 100 of about 722,561 (200)

Structural and Molecular Evolutionary Analysis of Agouti and Agouti-Related Proteins

Chemistry & Biology, 2006
Agouti (ASIP) and Agouti-related protein (AgRP) are endogenous antagonists of melanocortin receptors that play critical roles in the regulation of pigmentation and energy balance, respectively, and which arose from a common ancestral gene early in vertebrate evolution.
Jackson, Pilgrim J., Douglas, Nick R., Chai, Biaoxin, Binkley, Jonathan, Sidow, Arend, Barsh, Gregory S., Millhauser, Glenn L.   +6 more
openaire   +2 more sources

Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals.
Naira da Silva Mansano, Calvin Vinh Lieu, Alfonso Abizaid   +2 more
wiley   +1 more source

Food intake regulation during pregnancy and lactation in mice with reduced activity of the melanocortin system

Вавиловский журнал генетики и селекции, 2016
Hypothalamic melanortin receptor (MCR) activation inhibits appetite. Neuropeptide Y (NPY) and Agouti Related Protein (AgRP) are coexpressed in some hypothalamic neurons and stimulate feeding, NPY via inhibition of MCR-expressing neurons, and AgRP via ...
E. N. Makarova, I. V. Romanova, N. M. Bazhan   +2 more
doaj   +1 more source

The gatekeepers of growth: The neural roles and regulation of growth hormone‐releasing hormone neurons

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract The neuroendocrine control of growth is mediated by the hypothalamic–pituitary–somatic (HPS) axis. This involves the hypothalamic release of growth hormone‐releasing hormone (GHRH), which stimulates the pituitary secretion of growth hormone (GH).
Bradley B. Jamieson
wiley   +1 more source

Editorial: Glucosensing impact on glucose metabolism: From fish to mammals

Frontiers in Endocrinology, 2023
Xiao-Chen Yuan, Ya-Xiong Tao
doaj   +1 more source

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Frontiers in Neuroscience, 2017
The understanding of the mechanisms whereby energy balance is regulated is essential to the unraveling of the pathophysiology of obesity. In the last three decades, focus was put on the metabolic role played by the hypothalamic neurons expressing ...
Damien Lanfray, Denis Richard
doaj   +1 more source

Effects of Agouti Related Protein and Androgens on Growth

Journal of Applied Sciences, 2003
A dominant mutation at the agouti locus on mouse chromosome 2 is a promoter of overeating and increased linear growth. Agouti related protein, which can be produced using bacteria can be used to reproduce the same growing effect. Androgens are known to promote leanness and increased growth.
openaire   +1 more source

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier

Cell Reports, 2017
Neurons expressing agouti-related protein (AgRP) are essential for feeding. The majority of these neurons are located outside the blood-brain barrier (BBB), allowing them to directly sense circulating metabolic factors. Here, we show that, in adult mice,
Ernie Yulyaningsih, Ivan A. Rudenko, Martin Valdearcos, Emma Dahlén, Eirini Vagena, Alvin Chan, Arturo Alvarez-Buylla, Christian Vaisse, Suneil K. Koliwad, Allison W. Xu   +9 more
doaj   +1 more source

Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

Cell Reports
Summary: Rapid gut-brain communication is critical to maintain energy balance and is disrupted in diet-induced obesity. In particular, the role of carbohydrate overconsumption in the regulation of interoceptive circuits in vivo requires further ...
Carolyn M. Lorch, Nikolas W. Hayes, Jessica L. Xia, Stefan W. Fleps, Hayley E. McMorrow, Haley S. Province, Joshua A. Frydman, Jones G. Parker, Lisa R. Beutler   +8 more
doaj   +1 more source

Agouti and Agouti-related Protein: Analogies and Contrasts [PDF]

Journal of Biological Chemistry, 2000
D M, Dinulescu, R D, Cone
openaire   +2 more sources