Results 151 to 160 of about 722,561 (200)

Novel Agouti-Related-Protein-Based Melanocortin-1 Receptor Antagonist

Journal of Medicinal Chemistry, 2001
The melanocortin receptors are G-protein coupled receptors (GPCRs) that activate the cAMP signal transduction pathway and are stimulated by the melanocortin agonist alpha-melanocyte stimulating hormone (alpha-MSH). Members of these melanocortin receptors are antagonized by agouti (ASP) and agouti-related protein (AGRP), which are the only known ...
R, Thirumoorthy, J R, Holder, R M, Bauzo, N G, Richards, A S, Edison, C, Haskell-Luevano   +5 more
openaire   +2 more sources

The agouti-related protein and body fatness in humans

International Journal of Obesity, 2003
The objective of this study was to examine the impact of a single nucleotide polymorphism (SNP) (-38C>T) in the promoter of the human agouti-related protein (hAgRP) gene on promoter affinity for transcription factors (TFs) and its possible association with body composition phenotypes.Electrophoretic mobility shift assays for the functional studies and ...
G, Argyropoulos, T, Rankinen, F, Bai, T, Rice, M A, Province, A S, Leon, J S, Skinner, J H, Wilmore, D C, Rao, C, Bouchard   +9 more
openaire   +2 more sources

Agouti-related protein is a mediator of diabetic hyperphagia

Regulatory Peptides, 2001
To explore the role of agouti-related protein (AGRP) in diabetic hyperphagia changes in hypothalamic AGRP mRNA levels were examined in diabetic rats. Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was ...
S Y, Qu, Y K, Yang, J Y, Li, Q, Zeng, I, Gantz   +4 more
openaire   +2 more sources

Plasma agouti-related protein levels in women with anorexia nervosa

Psychoneuroendocrinology, 2006
Agouti-related protein (AGRP) is the competitive antagonist of alpha-melanocyte stimulating hormone (alpha-MSH) located at melanocortin receptors 3 and 4 (MC3R and MC4R), and also acts as an MC4R inverse agonist. Hypothalamic AGRP controls food intake and body weight in rodents. It has also been found in human plasma.
Junko, Moriya, Yoshiyuki, Takimoto, Kazuhiro, Yoshiuchi, Tatsuo, Shimosawa, Akira, Akabayashi   +4 more
openaire   +2 more sources

The Agouti-related protein and its role in energy homeostasis

Peptides, 2005
The melanocortin system plays an important role in the regulation of energy homeostasis. The Agouti-related protein (AGRP) is a natural antagonist of the action of alpha-melanocyte stimulating hormone (alpha-MSH) at the melanocortin receptors (MCR).
Adrian M, Stütz, Christopher D, Morrison, George, Argyropoulos   +2 more
openaire   +2 more sources

Agouti-related protein: More than a melanocortin-4 receptor antagonist?

Peptides, 2005
It is well established that agouti-related protein (AGRP) can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. However, there are clearly additional facets to the
Pritchard, Lynn E., White, Anne
openaire   +3 more sources

Serum alpha-melanocyte-stimulating hormone (a-MSH), brain-derived neurotrophic factor (BDNF), and agouti-related protein (AGRP) levels in children with Prader-Willi or Bardet-Biedl syndromes

Journal of Endocrinological Investigation, 2022
D. Turkkahraman, E. Sirazi, G. Aykal
semanticscholar   +1 more source

Central and peripheral interactions between the agouti-related protein and leptin

Biochemical and Biophysical Research Communications, 2004
The agouti-related protein (AgRP) is a powerful appetite modulator expressed in the hypothalamus and the adrenal gland and regulated by leptin. Here we report the robust expression of AgRP in epididymal fat and its upregulation in this tissue by feeding rather than by fasting.
Chantal, Charbonneau, Fulu, Bai, Brenda Smith, Richards, George, Argyropoulos   +3 more
openaire   +2 more sources

Agouti-related protein in the hypothalamic paraventricular nucleus: effect on feeding

Peptides, 2000
Agouti-related protein (Agrp) is an endogenous melanocortin-4 receptor antagonist implicated in the regulation of food intake. Effects of Agrp on feeding under varying conditions were investigated. Agrp (10 to 100 pmol) was injected into the hypothalamic paraventricular nucleus of satiated (a.m. and p.m.
M M, Wirth, S Q, Giraudo
openaire   +2 more sources

Treadmill Exercise’s Reduction of Agouti-Related Protein Expression in Rat Liver

International Journal of Sport Nutrition and Exercise Metabolism, 2009
Agouti-related protein (AGRP) is an orexigenic peptide secreted from the arcuate nucleus (ARC) of the hypothalamus. AGRP increases food intake and plays a role in energy balance, adiposity, weight gain, and growth-hormone release. The objective of the current study was to examine the effects of running exercise on resting hepatic, fundus, and pancreas ...
Abbass, Ghanbari-Niaki, Rozita, Fathi, Sayed Alireza Hossaini, Kakhak, Zhara, Farshidi, Sara, Barmaki, Fatemeh, Rahbarizadeh, Robert R, Kraemer   +6 more
openaire   +2 more sources