Alpha-Melanocyte-Stimulating Hormone and Agouti-Related Protein: Do They Play a Role in Appetite Regulation in Childhood Obesity? [PDF]
J Clin Res Pediatr Endocrinol, 2016 Objective: The hypothalamus plays a crucial role in the regulation of feeding behavior. The anorexigenic neuropeptide alpha-melanocyte-stimulating hormone (α-MSH) and the orexigenic neuropeptide agouti-related protein (AgRP) are among the major peptides ...
Vehapoğlu A, Türkmen S, Terzioğlu Ş.
europepmc +2 more sources
Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.
Endocrinology, 2018 Maier MT +6 more
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A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands. [PDF]
J Med Chem, 2017 Ericson MD +3 more
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Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles. [PDF]
ACS Chem Neurosci, 2018 The melanocortin-3 and melanocortin-4 receptors (MC3R and MC4R), endogenous agonists derived from the proopiomelanocortin gene transcript, and naturally occurring antagonists agouti and agouti-related protein (AGRP) have been linked to biological ...
Ericson MD +4 more
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Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor. [PDF]
J Med Chem, 2017 Ericson MD +4 more
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Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice
Frontiers in Neuroscience, 2023 IntroductionOcclusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment.
Junya Kusumoto +9 more
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Peroxisome proliferator-activated receptor γ controls ingestive behavior, agouti-related protein, and neuropeptide Y mRNA in the arcuate hypothalamus. [PDF]
J Neurosci, 2015 Peroxisome proliferator-activated receptor γ (PPARγ) is clinically targeted for type II diabetes treatment; however, rosiglitazone (ROSI), a PPARγ agonist, increases food intake and body/fat mass as side-effects. Mechanisms for these effects and the role
Garretson JT +5 more
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Agouti-related protein prevents self-starvation [PDF]
Molecular Psychiatry, 2003 Food restriction leads to a paradoxical increase in physical activity and further suppression of food intake, such as observed in anorexia nervosa.(1,2) To understand this pathophysiological process, we induced physical hyperactivity and self-starvation in rats by restricting food in the presence of running wheels.
Kas, M.J.H. +3 more
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Does an acute bout of high intensity interval exercise suppress appetite in obese women?
Pedagogy of Physical Culture and Sports, 2020 Purpose: The aim of this study was to investigate the 24 hour response of appetite and energy intake and the amount of Agouti-Related Protein to the high intensity interval exercise in obese untrained women.
Sepideh Khalaj, Bahman Mirzaei
doaj +1 more source
Agouti-Signalling Protein Overexpression Reduces Aggressiveness in Zebrafish
Biology, 2023 Feeding motivation plays a crucial role in food intake and growth. It closely depends on hunger and satiation, which are controlled by the melanocortin system.
Ana Rocha +3 more
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