Results 31 to 40 of about 722,561 (200)
Dmbx1 is essential in agouti-related protein action [PDF]
Proceedings of the National Academy of Sciences, 2007 Dmbx1 is a paired-class homeodomain transcription factor. We show here that mice deficient in Dmbx1 exhibit severe leanness associated with hypophagia and hyperactivity and that isolation of a Dmbx1 −/− mouse from its cohabitants induces self-starvation, sometimes leading to death,
Wakako, Fujimoto +9 more
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Characterization of Agouti-Related Protein Binding to Melanocortin Receptors [PDF]
Molecular Endocrinology, 1999 Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin action that is thought to play an important role in the hypothalamic control of feeding behavior. The exact mechanism of AGRP and Agouti protein action has been difficult to examine, in part because of difficulties in producing homogeneous forms of these molecules that ...
Y K, Yang +6 more
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Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. [PDF]
PLoS ONE, 2012 Beside its role in melanogenesis, the agouti signaling protein (ASIP) has been related to obesity. The potentially crucial role in adipocyte development makes it a tempting candidate for economic relevant, fat related traits in farm animals.
Elke Albrecht +3 more
doaj +1 more source
Frontiers in Systems Neuroscience, 2015 A major question in systems neuroscience is how a single population of neurons can interact with the rest of the brain to orchestrate complex behavioral states. The hypothalamus contains many such discrete neuronal populations that individually regulate
Allison eGraebner +2 more
doaj +1 more source
Role of Agouti-Related Protein-Expressing Neurons in Lactation [PDF]
Endocrinology, 2007 Hypothalamic neurons that express agouti-related protein (AgRP) and neuropeptide Y (NPY) are thought to be important for regulation of feeding, especially under conditions of negative energy balance. The expression of NPY and AgRP increases during lactation and may promote the hyperphagia that ensues.
Colin T, Phillips, Richard D, Palmiter
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Chinese journal of physiology, 2019 The objective of this study was to evaluate the association between adiposity parameters and fasting serum levels of appetite-regulating peptides: leptin, neuropeptide Y (NPY), desacyl ghrelin, peptide YY(1-36), obestatin, cocaine- and amphetamine ...
Anna Lucka, A. Wysokiński
semanticscholar +1 more source
Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 The 5’-adenosine monophosphate-activated protein kinase (AMPK) is a key part of a kinase-signaling cascade that acts to maintain energy homeostasis. The objective of this experiment was to investigate the possible effects of fasting and refeeding on the ...
Liu Lei, Zhu Lixian
doaj +1 more source
The Journal of Poultry Science, 2022 Previous studies in mammalian obesity models have suggested that central transforming growth factor-β (TGF-β) controls the gene expression of appetite-regulating neuropeptides and peripheral energy metabolism.
Takaoki Saneyasu +5 more
doaj +1 more source
Contribution of Melanocortin Receptor Exoloops to Agouti-related Protein Binding [PDF]
Journal of Biological Chemistry, 1999 Agouti-related protein (AGRP) is an endogenous antagonist of melanocortin action that functions in the hypothalamic control of feeding behavior. Although previous studies have shown that AGRP binds three of the five known subtypes of melanocortin receptor, the receptor domains participating in binding and the molecular interactions involved are ...
Y K, Yang +5 more
openaire +2 more sources