Results 41 to 50 of about 722,561 (200)

AgRP neurons are not indispensable for body weight maintenance in adult mice

Cell Reports, 2023
Summary: In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in ...
Jing Cai, Jing Chen, Joshua Ortiz-Guzman, Jessica Huang, Benjamin R. Arenkiel, Yuchen Wang, Yan Zhang, Yuyan Shi, Qingchun Tong, Cheng Zhan   +9 more
doaj   +1 more source

Transcriptional Regulation of Agouti-Related Protein (Agrp) in Transgenic Mice [PDF]

Endocrinology, 2004
AbstractAgouti-related protein (Agrp) encodes a hypothalamic neuropeptide that promotes positive energy balance by stimulating food intake and reducing energy expenditure. Agrp expression in the brain is restricted to neurons within the arcuate nucleus of the hypothalamus, and expression levels are elevated as a consequence of food deprivation.
Christopher B, Kaelin, Allison Wanting, Xu, Xin-Yun, Lu, Gregory S, Barsh   +3 more
openaire   +2 more sources

Blood levels of agouti-related peptide (AgRP), obestatin, corticosteroid-binding globulin (CBG), and cortisol in patients with bipolar disorder (BD): a case–control study

Psychiatry and Clinical Psychopharmacology, 2019
OBJECTIVES: Bipolar disorder (BD) is a chronic psychiatric disorder with a high prevalence of obesity. There are a number of hypotheses regarding the association between obesity and BD.
Evrim Özkorumak Karagüzel, Birgül Vanizor Kural, Ahmet Tiryaki, İlkay Keleş Altun, Serap Yaman Özer, Filiz Civil Arslan   +5 more
doaj   +1 more source

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus

Molecular Metabolism, 2017
Objectives: Phytocannabinoids, such as THC and endocannabinoids, are well known to promote feeding behavior and to control energy metabolism through cannabinoid type 1 receptors (CB1R).
Yury M. Morozov, Marco Koch, Pasko Rakic, Tamas L. Horvath   +3 more
doaj   +1 more source

A genetic variant of fatty acid amide hydrolase (FAAH) exacerbates hormone-mediated orexigenic feeding in mice

eLife, 2023
Fatty acid amide hydrolase (FAAH) degrades the endocannabinoid anandamide. A polymorphism in FAAH (FAAH C385A) reduces FAAH expression, increases anandamide levels, and increases the risk of obesity.
Georgia Balsevich, Gavin N Petrie, Daniel E Heinz, Arashdeep Singh, Robert J Aukema, Avery C Hunker, Haley A Vecchiarelli, Hiulan Yau, Martin Sticht, Roger J Thompson, Francis S Lee, Larry S Zweifel, Prasanth K Chelikani, Nils C Gassen, Matthew N Hill   +14 more
doaj   +1 more source

PGC-1α expression in murine AgRP neurons regulates food intake and energy balance

Molecular Metabolism, 2016
Objective: Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Jonathan F. Gill, Julien Delezie, Gesa Santos, Christoph Handschin   +3 more
doaj   +1 more source

Coordinated regulation of hepatic energy stores by leptin and hypothalamic agouti-related protein.

J Neurosci, 2013
Warne JP, Varonin JM, Nielsen SS, Olofsson LE, Kaelin CB, Chua S, Barsh GS, Koliwad SK, Xu AW.   +8 more
europepmc   +2 more sources

Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats

Turkish Journal of Kinesiology, 2017
The hypothalamus is a strong central controller of appetite that secretes different neuropeptides including AGRP. Plasma levels of AGRP are effective in controlling obesity and hunger.
Javad Mehrabani, Maryam Sedighianrad, Nasrin Ramezani, Hadi Nobari, Reza Bagheri   +4 more
doaj   +2 more sources

Genetic characterization of coat color genes in Brazilian Crioula sheep from a conservation nucleus [PDF]

Pesquisa Agropecuária Brasileira, 2017
: The objective of this work was to identify single nucleotide polymorphisms (SNPs) in resequencing data from MC1R, ASIP, and TYRP1 genes derived from Crioula sheep (Ovis aris) with different coat colors.
Lilian Cristina Gomes Cavalcanti, José Carlos Ferrugem Moraes, Danielle Assis de Faria, Concepta Margaret McManus, Alcebiades Renato Nepomuceno, Carlos José Hoff de Souza, Alexandre Rodrigues Caetano, Samuel Rezende Paiva   +7 more
doaj   +1 more source

Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI

BMC Medical Genetics, 2009
Background The agouti related protein (AGRP) is an endogenous antagonist of the melanocortin 4 receptor and is one of the most potent orexigenic factors.
Ignatovica Vita, Pirags Valdis, Kapa Ivo, Kalnina Ineta, Schiöth Helgi B, Klovins Janis   +5 more
doaj   +1 more source