Results 51 to 60 of about 722,561 (200)

Agouti Related Protein (AgRP) is Upregulated in Cushing's Syndrome

Experimental and Clinical Endocrinology & Diabetes, 2005
Alpha melanocyte-stimulating hormone (alpha-MSH) is an agonist at the melanocortin 3 (MC3-R) and melanocortin 4 (MC4-R) receptors. Alpha-MSH stimulates corticosterone release from rat and human adrenal cells. Patients with Cushing's syndrome have elevated levels of serum alpha-MSH.
Dhillo, WS, Gardiner, JV, Castle, L, Bewick, GA, Smith, KL, Meeran, K, Todd, JF, Ghatei, MA, Bloom, S. R.   +8 more
openaire   +4 more sources

Neuroendocrine and Molecular Interactions in Eating Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2014
There are three basic pillars for the development of eating disorders: genetic predisposition, neuro-endocrine-molecular changes in the brain and metabolic response to it.
Selma Bozkurt Zincir
doaj   +1 more source

Agouti-related protein-deficient mice display an age-related lean phenotype [PDF]

Cell Metabolism, 2005
Endogenous modulators of the central melanocortin system, such as the agouti-related protein (AgRP), should hold a pivotal position in the regulation of energy intake and expenditure. Despite this, AgRP-deficient mice were recently reported to exhibit normal food intake, body weight gain, and energy expenditure.
Wortley, Katherine E., Anderson, Keith D., Yasenchak, Jason, Murphy, Andrew, Valenzuela, David, Diano, Sabrina, Yancopoulos, George D., Wiegand, Stanley J., Sleeman, Mark W.   +8 more
openaire   +2 more sources

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

Facing the Challenges of Neuropeptide Gene Knockouts: Why Do They Not Inhibit Reproduction in Adult Teleost Fish?

Frontiers in Neuroscience, 2018
Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed.
Vance L. Trudeau
doaj   +1 more source

Effects of low energy availability on female reproductive function

Reproductive Medicine and Biology, 2022
Background It is known that metabolic and nutritional disturbances induce reproductive dysfunction in females. The main cause of these alterations is reduced gonadotrophin‐releasing hormone (GnRH) secretion from the hypothalamus, and the underlying ...
Takeshi Iwasa, Saki Minato, Junki Imaizumi, Atsuko Yoshida, Takako Kawakita, Kanako Yoshida, Yuri Yamamoto   +6 more
doaj   +1 more source

111In-labeled cystine-knot peptides based on the Agouti-related protein for targeting tumor angiogenesis. [PDF]

J Biomed Biotechnol, 2012
Agouti-related protein (AgRP) is a 4-kDa cystine-knot peptide of human origin with four disulfide bonds and four solvent-exposed loops. The cell adhesion receptor integrin αvβ3 is an important tumor angiogenesis factor that determines the invasiveness ...
Jiang L, Miao Z, Kimura RH, Silverman AP, Ren G, Liu H, Lu H, Cochran JR, Cheng Z.   +8 more
europepmc   +2 more sources

Plasma Levels of Agouti-Related Protein Are Increased in Obese Men [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
To investigate the relationship between peripheral blood levels of agouti-related protein (AGRP) and various parameters of obesity, we measured the plasma level of AGRP in 15 obese and 15 nonobese men and evaluated its relationship with body mass index (BMI), body fat weight, and visceral, sc, and total fat areas measured by computed tomography ...
A, Katsuki, Y, Sumida, E C, Gabazza, S, Murashima, T, Tanaka, M, Furuta, R, Araki-Sasaki, Y, Hori, K, Nakatani, Y, Yano, Y, Adachi   +10 more
openaire   +2 more sources

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin.

PLoS ONE, 2012
Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti ...
Luís Martins, Diana Fernández-Mallo, Marta G Novelle, María J Vázquez, Manuel Tena-Sempere, Rubén Nogueiras, Miguel López, Carlos Diéguez   +7 more
doaj   +1 more source