Agouti-related protein - Open Access .click

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Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling* [PDF]

Endocrinology, 1999
Agouti-related protein (AGRP) is an orexigenic neuropeptide that acts via central melanocortin receptors, and whose messenger RNA (mRNA) levels are elevated in leptin-deficient mice. Fasting associated with a decline in circulating leptin normally causes a 15-fold elevation of hypothalamic Agrp mRNA levels but has no effect in leptin-deficient mice ...
B D, Wilson +6 more
openaire +2 more sources

The emerging role of CAMK1D in diabetes, metabolism and feeding behaviours: A mechanistic systematic review

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
This systematic review synthesizes evidence from published studies, GWAS and grey literature (patents) to show that CAMK1D is implicated in diabetes, obesity, insulin resistance and altered feeding behaviours, with diagnostic potential and mechanistic relevance through regulatory binding and tissue‐specific effects.
Livio Tarchi +13 more
wiley +1 more source

Modeling Obesity and Weight Loss in Mice Using Novel AAV Approaches

Obesity, Volume 34, Issue 2, Page 417-427, February 2026.
ABSTRACT Objective This study utilized AAV gene delivery as an approach to induce and reverse hyperphagia in mice. We hypothesized that the delivery of orexigenic neuropeptides to the brain via AAV precipitates obesity and that the implementation of genetic switches to reverse transgene expression would elicit weight loss.
Hunter G. Sellers +12 more
wiley +1 more source

Hypothalamic Melanocortin System on Feeding Regulation in Birds: A Review

The Journal of Poultry Science, 2011
Regulation of feed intake in chickens represents a complex homeostatic mechanism involving multiple levels of control. Understanding the regulation of feeding behavior can be a very important theme in animal production.
Takashi Bungo +2 more
doaj +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source

The Melanocortin System in Atlantic Salmon (Salmo salar L.) and Its Role in Appetite Control

Frontiers in Neuroanatomy, 2020
The melanocortin system is a key neuroendocrine network involved in the control of food intake and energy homeostasis in vertebrates. Within the hypothalamus, the system comprises two main distinct neuronal cell populations that express the neuropeptides
Tharmini Kalananthan +7 more
doaj +1 more source

Case Series of Nizon‐Isidor Syndrome by Heterozygous Variants in MED12L With Further Evidence of Mitotic Instability in One Case With Diploid–Triploid Mosaicism

American Journal of Medical Genetics Part A, Volume 200, Issue 1, Page 205-214, January 2026.
ABSTRACT Nizon‐Isidor syndrome is a rare disorder caused by heterozygous variants in MED12L, with only eight documented cases in the literature. Here, we present three additional cases of this syndrome. Proband 1 was a 7‐year‐old female who presented with developmental delay, right‐leg hemihypertrophy, laryngeal cleft, esotropia, abnormal skin ...
Russell Stewart +336 more
wiley +1 more source

Melatonin - leptin interaction and obesity-related genes

Trakya University Journal of Natural Sciences
Most living organisms have circadian clocks which maintain rhythm in internal cycles of behavior, physiology, and metabolism, allowing them to anticipate the earth's 24-hour rota-tion.
Emine İnci Balkan, Bülent Gündüz
doaj +1 more source

New Insights Into Ginseng and Clove Supplementation: Alleviating Obesity by Reducing Leptin Resistance and Reshaping the Gut Microbiota

Food Frontiers, Volume 7, Issue 1, January 2026.
AEGC conferred substantial resistance to weight gain and reduced food intake. AEGC may alleviate LR by regulating the levels of LEP and ADP. AEGC elevated the diversity of gut microbiota and reconstructed the composition. Changes such as CAG‐873 in gut microbiota may be the reason why AEGC alleviates LR.
Weifeng Ni +9 more
wiley +1 more source

Determinants of body weight regulation in humans

Archives of Endocrinology and Metabolism, 2016
Body weight is regulated by the ability of hypothalamic neurons to orchestrate behavioral, endocrine and autonomic responses via afferent and efferent pathways to the brainstem and the periphery.
Milene Moehlecke +5 more
doaj +1 more source

animals
intercellular signaling peptides and proteins
humans

proteins
2. zero hunger
hypothalamus

mice
obesity
leptin