Results 51 to 60 of about 35,433 (223)
Structural and Molecular Evolutionary Analysis of Agouti and Agouti-Related Proteins
Chemistry & Biology, 2006 Agouti (ASIP) and Agouti-related protein (AgRP) are endogenous antagonists of melanocortin receptors that play critical roles in the regulation of pigmentation and energy balance, respectively, and which arose from a common ancestral gene early in vertebrate evolution.
Jackson, Pilgrim J. +6 more
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Regulation of leptin by agouti [PDF]
Physiological Genomics, 2000 Claycombe, Kate J., Bing Zhong Xue, Randall L. Mynatt, Michael B. Zemel, and Naïma Moustaïd-Moussa. Regulation of leptin by agouti. Physiol Genomics 2: 101–105, 2000.—Dominant mutations at the mouse Agouti locus lead to ectopic expression of the Agouti gene and exhibit diabetes, obesity, and yellow coat color. Obese yellow mice are hyperinsulinemic and
K J, Claycombe +4 more
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Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source
The long-term impact of folic acid in pregnancy on offspring DNA methylation : follow-up of the Aberdeen folic acid supplementation trial (AFAST) [PDF]
, 2018 Funding This work was supported by the NIHR Bristol Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol.
Atkinson, Charlotte +14 more
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Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
Dystocia in a Captive Reared Agouti (Dasyprocta leporina) in Trinidad and Tobago, West Indies
Veterinary Sciences, 2020 Dystocia is a complication that occurs at parturition either due to foetal or maternal factors. This condition has been well studies in domesticated species. However, there is very little information on dystocia in the agouti (Dasyprocta leporina).
Kegan Romelle Jones +2 more
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Melanism in peromyscus is caused by independent mutations in agouti. [PDF]
PLoS ONE, 2009 Identifying the molecular basis of phenotypes that have evolved independently can provide insight into the ways genetic and developmental constraints influence the maintenance of phenotypic diversity.
Evan P Kingsley +3 more
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Detecting epistasis via Markov bases [PDF]
, 2010 Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
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Wildlife Biology, EarlyView.With urbanization reducing the amount of available wildlife habitat, and outdoor recreation increasing the human activity within wildlife habitats, it is important to understand the effects of human activity on animal behavior. This study examined how the reduction in human presence in urban parks in Gainesville, Florida, affected the temporal ...
Maya Fives, Matthew Hallett
wiley +1 more source