Results 181 to 190 of about 98,913 (262)

Validation of targets linked to weight gain in C57BL/6 mice and translational aspects in humans. [PDF]

Proc Natl Acad Sci U S A
Wu Y, Rudolf AM, Wang L, Zhang Z, Niu C, Xia F, Li M, Wang A, Mitchell SE, Zhang H, He Y, Chen C, Speakman JR.   +12 more
europepmc   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Neuroendocrine Carcinoma of the Head and Neck: A Two‐Decade Institutional Experience

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Primary neuroendocrine carcinoma (NEC) of the head and neck is rare (< 1% of cases) and aggressive, with poorly defined management strategies. This study evaluated clinical characteristics, treatment patterns, and survival outcomes in a single‐institution cohort, identifying factors associated with improved survival.
Micah K. Harris, Katie M. Carlson, Nathan Lu, Anthony Tang, Matthew E. Spector, Joshua D. Smith, Jessica H. Maxwell, Kevin J. Contrera, Seungwon Kim, Steven B. Chinn, Angela Mazul, Shaum S. Sridharan   +11 more
wiley   +1 more source

Aryl hydrocarbon receptor (AhR) regulates organic dust and organic dust-associated bacterial extracellular vesicles-induced airway inflammation via ROS-dependent NFκB and STAT3 activation. [PDF]

Respir Res
Meganathan V, Kusampudi S, Stenhouse M, Boggaram V.   +3 more
europepmc   +1 more source

Real‐World Effectiveness, Treatment Course, and Safety of Tapinarof Cream 1% for Atopic Dermatitis and Plaque Psoriasis in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Background Tapinarof cream 1%, a non‐steroidal topical aryl hydrocarbon receptor‐modulating agent, is approved in Japan for atopic dermatitis (AD) and plaque psoriasis. Real‐world data on longitudinal outcomes, treatment continuation, interruption and restart, and adverse‐event timing are limited. Methods This single‐center retrospective study
Kanade Iino, Saori Takamura, Tomoo Fukuda   +2 more
wiley   +1 more source

Cooperation or Conflict? Molecular and Physiological Cross-Talk Between the Aryl Hydrocarbon and Vitamin D Receptors. [PDF]

Pharmaceuticals (Basel)
Alqahtani MA.
europepmc   +1 more source

The Role of Vaginal Oestrogen Therapy in Postmenopausal Women With Pelvic Organ Prolapse: Does It Have Any Impact on Perioperative Outcomes? A Systematic Review of Randomised Controlled Trials

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Pelvic organ prolapse (POP) affects up to 50% of postmenopausal women, negatively impacting sexual function and quality of life. While surgery remains the primary treatment, increasing attention has been given to perioperative vaginal oestrogen therapy and its potential impact on surgical outcomes.
Gilda Sicilia, Salvatore Giovanni Vitale, Maurizio Nicola D'Alterio, Stefania Saponara, Francesco Scicchitano, Anna Maria Fulghesu, Rossella E. Nappi, Stefano Angioni   +7 more
wiley   +1 more source

Hypertensive Disorders of Pregnancy and the Long‐Term Risk of Maternal Retinal and Ophthalmic Disease: A Systematic Review and Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Hypertensive disorders of pregnancy (HDP) are associated with increased long‐term risk of maternal cardio‐metabolic disease, but links with future retinal diseases remain unclear. Objective The objective of this study is to synthesise the published literature on HDP and subsequent retinal and other ophthalmic disease.
Peter Barrett, Cian Carey, Sinéad O'Riordan, Angela Ding Wu, Emma Wallace, Matilda Biba, Karolina Kublickiene, Fergus McCarthy, Ali Khashan   +8 more
wiley   +1 more source

The aryl hydrocarbon receptor is expressed in non-sensory cells in the cochlea and regulates hair cell survival. [PDF]

Front Mol Neurosci
Pandey S, Cox BC.
europepmc   +1 more source

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source