Results 81 to 90 of about 66,077 (262)

Avoiding hypoglycemia: a key to success for glucose-lowering therapy in type 2 diabetes

Vascular Health and Risk Management, 2013
Bo Ahrén Department of Clinical Sciences, Lund, Faculty of Medicine, Lund University, Lund, Sweden Abstract: Type 2 diabetes carries a risk for hypoglycemia, particularly in patients on an intensive glucose control plan as a glucose-lowering ...
Ahrén B
doaj  

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

Advanced Science
Sphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters.
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson   +12 more
doaj   +1 more source

Impact of extended insurance coverage on survival outcomes among patients with metastatic colorectal cancer in Taiwan

British Journal of Clinical Pharmacology, EarlyView.
Aims Predetermined treatment duration limits (PTDLs) are often used by Taiwan's National Health Insurance Administration to contain healthcare costs, but they may compromise patient outcomes. Therefore, we studied Taiwan's 2017 extension of the bevacizumab PTDL from 24 to 36 weeks in metastatic colorectal cancer (mCRC) to evaluate whether prolonged ...
Wei‐Ming Huang, Chen‐Han Chueh, Chien‐Yu Tseng, Christopher N. Kaufmann, Earl J. Morris, Chiao‐En Wu, Yi‐Wen Tsai   +6 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin

Diabetes, Metabolic Syndrome and Obesity, 2010
Bo AhrénDepartment of Clinical Sciences, Lund University, Lund, SwedenAbstract: Inhibition of dipeptidyl peptidase-4 (DPP-4) prevents the inactivation of glucagonlike peptide-1 (GLP-1).
Bo Ahrén
doaj  

Mediating Effect of the Stay-at-Home Order on the Association between Mobility, Weather, and COVID-19 Infection and Mortality in Indiana and Kentucky: March to May 2020

Atmosphere
(1) Background: The association of COVID-19 infection and mortality with mobility and weather in Indiana and Kentucky was compared for the period from 1 March to 15 May 2020.
Shaminul H. Shakib, Bert B. Little, Seyed Karimi, William Paul McKinney, Michael Goldsby, Maiying Kong   +5 more
doaj   +1 more source

AHR Sequencing of pcDNA-AHR

Human AHR nucleic acid sequences were obtained from NCBI and primers were designed on Snapgene based on Nhe I and Hind III upstream and downstream digestion sites (Supplementary table 2). Total RNA from THP-1 cells was extracted using R401-01, and cDNA was synthesized using HiScript II 1st Strand cDNA Synthesis Kit (+gDNA wiper).
openaire   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma

Journal of Translational Medicine, 2019
The aryl hydrocarbon receptor (AhR) is a well-known ligand-activated cytoplasmic transcription factor that contributes to cellular responses against environmental toxins and carcinogens.
Hui Zhao, Lin Chen, Tian Yang, Ya-Long Feng, Nosratola D. Vaziri, Bao-Li Liu, Qing-Quan Liu, Yan Guo, Ying-Yong Zhao   +8 more
doaj   +1 more source

Rethinking Climate Change on the Role of Human Power Generation, Alternative Perspectives, Potential Solutions, and a Plea for Action

Chemie Ingenieur Technik, EarlyView.
All energy matters Let us broaden the discussion on solutions to climate change. Greenhouse gases have upset the delicate equilibrium of the Earth's energy balance. Consequently, all sources of heat affect the temperature of the Earth. Although the amount of additional heat generated by humans is a fraction of that produced by the sun, it is generated ...
Martin Bertau, Gerald Steiner, Tom Harwood   +2 more
wiley   +1 more source