Results 71 to 80 of about 98,913 (262)

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Combined Use of Intranasal Methylprednisolone and Allopregnanolone: Revisiting Anti-inflammatory and Remyelinating Treatment in a Murine Model of Multiple Sclerosis

Frontiers in Bioscience-Landmark
Background: Multiple sclerosis (MS) is a demyelinating, neuroinflammatory, progressive disease that severely affects human health of young adults.
Iván Nicolás Pérez-Osorio, José Alejandro Espinosa-Cerón, Camila Álvarez-Gutiérrez, Rodrigo Gonzalez-Flores, Hugo Besedovsky, Gladis Fragoso, Mónica A. Torres-Ramos, Edda Sciutto   +7 more
doaj   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

PPIs are AHR activators.

, 2019
A) CYP1B1 mRNA expression after 6h PPI treatment. Cells were treated with an AHR ligand positive control (FICZ) or proton pump inhibitors for 24h before RNA was isolated from cell lysates and analyzed for CYP1B1 mRNA expression using qPCR.
Collynn F. Woeller (7392527), Elisa Roztocil (7392509), Steven E. Feldon (7392515), Christine L. Hammond (7406342), Richard P. Phipps (7392512)   +4 more
core   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

AhR−/−mice have a horizontal pendular nystagmus.

, 2013
(A) Positions of the eyes of the AhR+/+ mice in both horizontal (EHp) and vertical (EVp) plans in the absence of head movements in the dark. (B) Positions of the eyes of 2 different AhR−/− mice showing spontaneous nystagmus at low frequency in light ...
Antoine Mialot (105606), Pedro Fernandez-Salguero (105608), Jean-Maurice Petit (105607), Mathieu Beraneck (105613), Aline Chevallier (105605), Robert Barouki (105609), Xavier Coumoul (9804)   +6 more
core   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Recombinant expression of functional mouse AhR LBD in E. coli [PDF]

, 2012
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic halogenated aromatic hydrocarbon, which is a potent toxin to different species such as fish, birds, and mammalians.
Elhawari, Wail
core  

AhR (Aryl Hydrocarbon Receptor) Polymorphisms: A Possible Role in TCDD (Dioxins)-AhR Binding and Carcinogenesis

, 2014
Carcinogenicity of dioxins seems to be largely mediated by their binding to the aryl hydrocarbon receptor (AhR), a cytosolic transcriptional regulator of cell growth, differentiation, and migration.
Ruggero Ridolfi, Floriana Boscaino, Luca Malorni, Giuseppe Palmieri, Antonio Malorni, Sergio Canzanella, Livia Malorni, Rosaria Cozzolino   +7 more
core   +1 more source

Aryl Hydrocarbon Receptor Promotes IL-10 Expression in Inflammatory Macrophages Through Src-STAT3 Signaling Pathway

Frontiers in Immunology, 2018
The aryl hydrocarbon receptor (AhR) is an important immune regulator with a role in inflammatory response. However, the role of AhR in IL-10 production by inflammatory macrophages is currently unknown.
Junyu Zhu, Li Luo, Lixing Tian, Shangqi Yin, Xiaoyuan Ma, Xiaoyuan Ma, Shaowen Cheng, Wanqi Tang, Jing Yu, Wei Ma, Xiaoying Zhou, Xia Fan, Xue Yang, Jun Yan, Xiang Xu, Chuanzhu Lv, Huaping Liang   +16 more
doaj   +1 more source