Results 51 to 60 of about 98,913 (262)

Canine Coronavirus Activates Aryl Hydrocarbon Receptor during In Vitro Infection

Viruses, 2022
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that interacts with substrates, including microbial metabolites.
Claudia Cerracchio, Francesco Serra, Maria Grazia Amoroso, Filomena Fiorito   +3 more
doaj   +1 more source

Short Heterodimer Partner (SHP) Orphan Nuclear Receptor Inhibits the Transcriptional Activity of Aryl Hydrocarbon Receptor (AHR)/AHR Nuclear Translocator (ARNT)

, 2001
SHP (short heterodimer partner) is an orphan nuclear receptor lacking a DNA binding domain that interacts with nuclear receptors (NR) including thyroid receptor (TR), retinoic acid receptors (RAR and RXR), and estrogen receptors α and β (ERα and ERβ ...
Lee, Jennie E, Tyulmenkov, Valentyn V, Prough, Russell A, Risinger, Kelly E, Klinge, Carolyn M, Falkner, K.Cameron, Jernigan, Sarah C   +6 more
core   +1 more source

Incident Comorbid Diabetes and Outcomes in Multiple Sclerosis: An English Population‐Based Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To compare the incidence of diabetes mellitus and its associations with hospitalisation and mortality in adults with multiple sclerosis (MS) and matched controls. Methods Using English primary care data from the Clinical Practice Research Datalink, linked to hospital and mortality records, we matched adults with MS with up to 10 ...
Yolanda Lau, Sedigheh Zabihi, Morghan Hartmann, Georgina Mathlin, Sube Banerjee, Ebaa Marouf, Clare Hadley, Claudia Cooper, Ruth Dobson   +8 more
wiley   +1 more source

Role of AHR in BaP internalization.

, 2014
(A) Internalization of BaP in to cell through AHR, metabolic conversion to BPDE and interaction of BPDE with DNA. (B) Preferential binding of TiO2NP with AHR.
Richa Gupta (365179), Snober Shabnam Mir (629034), Qazi Mohd. Sajid Jamal (629033), Madan Lal Bramha Bhatt (629035), Qamar Rahman (343083), Mohd. Haris Siddiqui (629036), Anupam Dhasmana (629032), Mohtashim Lohani (343084)   +7 more
core   +1 more source

Frailty Predicts Incident Osteoporotic Fractures in Veterans with Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Objective Rheumatoid arthritis (RA) is associated with an increased risk of frailty and osteoporosis, but the relationship between frailty and incident osteoporotic fractures in RA is underexplored. Methods Data were from the Veterans Affairs (VA) Rheumatoid Arthritis Registry. Frailty was measured using the VA Frailty Index (VAFI).
Katherine D. Wysham, Hannah F. Brubeck, Aaron Baraff, Punyasha Roul, Namrata Singh, James S. Andrews, Grant W. Cannon, Gary A. Kunkel, Ted R. Mikuls, Bryant R. England, Dolores M. Shoback, Patricia P. Katz, Jose M. Garcia, Ariela R. Orkaby, Joshua F. Baker   +14 more
wiley   +1 more source

Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice

Nature Communications, 2023
The human aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is a pivotal regulator of human physiology and pathophysiology. Allosteric inhibition of AhR was previously thought to be untenable.
Karolína Ondrová, Iveta Zůvalová, Barbora Vyhlídalová, Kristýna Krasulová, Eva Miková, Radim Vrzal, Petr Nádvorník, Binod Nepal, Sandhya Kortagere, Martina Kopečná, David Kopečný, Marek Šebela, Fraydoon Rastinejad, Hua Pu, Miroslav Soural, Katharina Maria Rolfes, Thomas Haarmann-Stemmann, Hao Li, Sridhar Mani, Zdeněk Dvořák   +19 more
doaj   +1 more source

AHR–PIN versus Random PINs

, 2013
(A–D) AHR–PINs at various Dmax levels. AHR modifiers are highlighted with bigger green nodes. A total of 48, 46, 34, and three AHR modifiers are interconnected in the AHR–PINs with Dmax values of 4, 3, 2, and 1, respectively.
Mark Craven (51222), Guang Yao (42533), Norman Drinkwater (70459), Christopher A Bradfield (70460)   +3 more
core   +1 more source

Extending Service Beyond Active Duty: Generalizability of Rheumatoid Arthritis Research Conducted Among US Veterans

Arthritis Care &Research, EarlyView.
Biomedical research involving US veterans continues to advance health care beyond the Veterans Health Administration. This is particularly true in rheumatoid arthritis (RA), where veteran‐centric research has uncovered novel insights into pathogenesis, risk factors, and disease manifestations, informing clinical care and research across both veteran ...
Austin M. Wheeler, Joshua F. Baker, Jennifer L. Barton, Maria I. Danila, Tate M. Johnson, Kamini Kuchinad, Kaleb Michaud, Amir A. Razmjou, J. Steuart Richards, Namrata Singh, Isaac D. Smith, Katherine D. Wysham, Grant W. Cannon, Bryant R. England, Amy Joseph, Deana Lazaro, Katherine P. Liao, Courtney Loecker, Andreas Reimold, Beth I. Wallace, Ted R. Mikuls   +20 more
wiley   +1 more source

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

The Aryl Hydrocarbon Receptor Attenuates Acute Cigarette Smoke-Induced Airway Neutrophilia Independent of the Dioxin Response Element

Frontiers in Immunology, 2021
Cigarette smoke is a prevalent respiratory toxicant that remains a leading cause of death worldwide. Cigarette smoke induces inflammation in the lungs and airways that contributes to the development of diseases such as lung cancer and chronic obstructive
Angela Rico de Souza, Hussein Traboulsi, Hussein Traboulsi, Xinyu Wang, Xinyu Wang, Xinyu Wang, Jorg H. Fritz, David H. Eidelman, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole   +11 more
doaj   +1 more source