Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang +3 more
wiley +1 more source
Influence of Hypoxia on the Airway Epithelium. [PDF]
Procházková K, Uhlík J.
europepmc +1 more source
Decreased Production of Tissue Plasminogen Activator in Endothelial Cells From Nasal Polyps
ABSTRACT Introduction Previous studies have demonstrated that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition which is related to impaired production of tissue plasminogen activator(t‐PA) by epithelial cells.
Qian‐Qian Zhang +9 more
wiley +1 more source
Modulatory effects of CeO<sub>2</sub> nanoparticles on bleomycin-induced active pulmonary disease processes in animal and human airway epithelium models. [PDF]
Guo C +8 more
europepmc +1 more source
Research Progress on Upper Airway Cough Syndrome
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley +1 more source
The Direct and Indirect Role of IgE on Airway Epithelium in Asthma. [PDF]
Domingo C +7 more
europepmc +1 more source
Inflammatory Shift in Chronic Rhinosinusitis Amidst Guangzhou's Urbanization (2000–2018)
ABSTRACT Background Chronic rhinosinusitis (CRS) exhibits temporal and geographic diversity in pathological endotypes with progressive eosinophilic infiltration, while the underlying causes remain unclear. Current pathological endotypes determination relies on mean cell count per high‐power field, requiring accuracy optimization.
Ning Kang +16 more
wiley +1 more source
Bat Tongues and Foraging: Linking Morphology to Hunting Strategies
We linked the bat tongue's mediodorsal lobe (MDL), a muscular prominence, to foraging strategies. Aerial hawkers exhibit tall MDLs and prominent forward‐pointing papillae. The MDL may function as a barrier or filter, preventing unintentional ingestion of non‐food material, aiding in prey handling, and controlling food access during fast flight ...
Danilo Russo +6 more
wiley +1 more source
The apical mucus layer alters the pharmacological properties of the airway epithelium. [PDF]
Guidone D +5 more
europepmc +1 more source
Role for Complement C5 in Eosinophilic Inflammation of Severe Asthma
Complement activation module, particularly C5, is positively associated with eosinophilic inflammation in severe asthma cohorts. Elevated C5 expression correlates with poor lung function improvement and persistent eosinophilic inflammation. Mouse model studies confirm that C5 exacerbates eosinophilic inflammation, highlighting its potential as a ...
Cong Dong +217 more
wiley +1 more source

