Results 221 to 230 of about 803,336 (334)

Chloroplast Fibrillin‐Mediated α‐Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance

Advanced Science, EarlyView.
ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu, Xuedong Liu, Qin Yan, Xi Chen, Lianyi Zang, Jingang Hu, Xiaoping Zhu, Zaifeng Fan, Tao Zhou   +8 more
wiley   +1 more source

Effects of risperidone on amino acid metabolism, glucose, and kidney function in healthy adults: A pilot randomized controlled trial. [PDF]

PLoS One
Oshima M, Toyama T, Nakade Y, Miyagi S, Ogura H, Nakagawa S, Yuasa T, Koshino A, Horikoshi K, Minami T, Sako K, Tsuge S, Tamai A, Nishioka R, Miyagawa T, Ito K, Kitajima S, Mizushima I, Hara A, Sakai N, Shimizu M, Tokumaru T, Tsubomoto M, Kikuchi M, Kinoshita M, Nakada M, Mita M, Iwata Y, Wada T.   +28 more
europepmc   +1 more source

Nucleotide sequence of a cDNA for the bovine myristoylated alanine-rich C kinase substrate (MARCKS)

, 1989
Deborah J. Stumpo, Jonathan M. Graff, Katherine A. Albert, Paul Greengard, Perry J. Blackshear   +4 more
openalex   +2 more sources

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Dosing strategies for β-alanine supplementation in strength and power performance: a systematic review. [PDF]

J Int Soc Sports Nutr
Ong SW, Chen WL, Chien KY, Hsu CW.
europepmc   +1 more source

Development of a MALDI-TOF-MS Method for the Analysis of Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Search of BMAA Incorporation in Biological Samples

, 2015
Laura Conklin
openalex   +2 more sources

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Separation and detection of Gram-negative bacteria via vancomycin-functionalized magnetic beads and aminopeptidase test strips. [PDF]

Front Bioeng Biotechnol
Xu X, Zhu A, Bai L, Li S, Ge W, Yang Y, Liu X, Qin Z, Li Z, Li J.   +9 more
europepmc   +1 more source

Modulation of the Bacterial Mechanosensitive Channel of Small Conductance (MSCS) by Cardiolipin - Electrophysiological, Alanine Mutagenesis and Modelling Studies [PDF]

, 2014
Pietro Ridone, Samantha Maguire, Boris Martinac, Andrew R. Battle   +3 more
openalex   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source