Results 221 to 230 of about 814,837 (335)

Alanine Mutagenesis Identifies Specific Amino Acids of Nemertide Alpha-1 Activity and Its Binding to Target Receptors. [PDF]

J Nat Prod
Laborde Q, Peigneur S, Jacobsson E, Göransson U, Tytgat J, Andersson HS.   +5 more
europepmc   +1 more source

Chiral metal complexes. 15∗. Alanine and proline complexes of [N,N′-di(2-picolyl)-1R, 2R-diaminocyclohexane] cobalt (III)

, 1984
Robert S. Vagg, Terence J. Goodwin, Peter A. Williams   +2 more
openalex   +2 more sources

Formation of β-Alanine by Pine Tissues Supplied With Intermediates in Uracil & Orotic Acid Metabolism [PDF]

, 1962
Robert L. Barnes, Aubrey W. Naylor
openalex   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

The Association Between Amino Acids and the Onset and Progression of Type 2 Diabetes Mellitus: A Comprehensive Analysis Based on UK Biobank Database. [PDF]

J Diabetes Res
Yang J, Wu Z, Fang J, Zhang Z, Huang J, Wang Y, Cui J, Ruan S, Yan Q, Wu Q, Chen S, Hou B, Huang S, Zhang C.   +13 more
europepmc   +1 more source

ALANINE DECREASES THE PROTEIN REQUIREMENT OF INFANTS METABOLISM [PDF]

, 1984
Jon A. Wolff, Susan J. Algert, Drew Kelts, William L. Nyhan   +3 more
openalex   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Building multiscale Markov state models by systematic mapping of temporal communities. [PDF]

Bioinformatics
Nitskansky N, Clein K, Raveh B.
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Targeting emerging amino acid dependencies and transporters in cancer therapy. [PDF]

Front Pharmacol
Akinlalu A, Ogberefor E, Gao T, Sun D.
europepmc   +1 more source