Results 131 to 140 of about 13,748 (218)

SP0049 Dna aggregates as alarmins [PDF]

Annals of the Rheumatic Diseases, 2017
DNA is a large polymeric molecule that displays powerful immunological activities and operates in the context of multi-component aggregates to alarm the immune system and stimulate innate immunity. Although DNA has important roles in normal host defense, DNA can serve as an autoantigen and autoimmunogen by itself or in association with other ...
openaire   +1 more source

Rapid and long‐lasting remission of refractory Hailey‐Hailey disease by IL‐13 inhibition with tralokinumab

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Oliver Brandt, Stephanie M. Huber, Simon M. Mueller   +2 more
wiley   +1 more source

A Systematic Review and Meta‐Analysis on the Induction of Confirmed Eosinophilic Esophagitis as a Side Effect of Allergen Immunotherapy: An EAACI Task Force Report

Allergy, Volume 81, Issue 4, Page 1024-1038, April 2026.
ABSTRACT The European Academy of Allergy and Clinical Immunology (EAACI) established a Task Force to assess the existing data on the relationship between eosinophilic esophagitis (EoE) and allergen immunotherapy (AIT). This systematic review and meta‐analysis aimed to study the incidence of confirmed EoE, developing as a side effect of AIT to food or ...
Carlo Maria Rossi, Ingrid Terreehorst, Evaggelia Apostolidou, Martina Votto, Arzu Bakirtas, Antonella Cianferroni, George N. Konstantinou, Katerina Pantavou, Dario Antolin‐Amerigo, Enrico Heffler, Alberto Alvarez‐Perea, Montserrat Fernandez‐Rivas, Georgios K. Nikolopoulos, Oliver Pfaar, Constantinos Pitsios   +14 more
wiley   +1 more source

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, Volume 81, Issue 4, Page 1000-1023, April 2026.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 proteins

The FEBS Journal, Volume 293, Issue 7, Page 2042-2066, April 2026.
Calcium‐binding S100 proteins are important mediators of inflammation in humans. Distant members of this family have been recently discovered in teleost fish but their resemblance to human proteins has not been explored yet. This study demonstrates that zebrafish‐specific S100i1 and S100i2 (ictacalcins) possess identical structural organization and ...
Liz Hernández, Théo Paris, Maria Demou, Catherine Birck, Christina Begon‐Pescia, Juan Francisco Rodríguez Vidal, Sylwia D. Tyrkalska, Charlotte Bureau, Catherine Gonzalez, Juliette Gracia, Etienne Lelièvre, Victoriano Mulero, Mai Nguyen‐Chi, Laure Yatime   +13 more
wiley   +1 more source

Porphyromonas gingivalis–Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein‐1 Canonical Signaling

Molecular Oral Microbiology, Volume 41, Issue 2, Page 85-93, April 2026.
ABSTRACT Periodontal bacterial pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs) accelerate inflammatory osteoclastogenesis, resulting in alveolar bone loss. The core PAMP and DAMP prototype molecules are periodontal bacterium Porphyromonas gingivalis–derived virulence lipids, for example, phosphoglycerol ...
Chiaki Yamada, Gang Peng, James A. Johnson Jr., Amilia Nusbaum, Natasha Sanz, Hawra AlQallaf, Frank Nichols, Alexandru Movila   +7 more
wiley   +1 more source

TSLP: contrasting roles in cancer

Frontiers in Immunology
Thymic stromal lymphopoietin (TSLP) is an alarmin cytokine possessing a plethora of pleiotropic properties. Human and mouse TSLP exerts their activity via a heterodimeric complex composed of TSLP receptor (TSLPR) chain and IL-7Rα.
Remo Poto, Remo Poto, Remo Poto, Gianni Marone, Gianni Marone, Gianni Marone, Steven F. Ziegler, Steven F. Ziegler, Steven F. Ziegler, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi   +11 more
doaj   +1 more source

Suppressing alarmins [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Calprotectin and Sarcopenia in COPD: Biomarker, Bystander or Target?

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
Irena Sarc, Ramon Langen, Harry Reinier Gosker, Mitja Lainscak   +3 more
wiley   +1 more source

Alarmins and More [PDF]

Clinical Therapeutics, 2016
openaire   +2 more sources