Results 51 to 60 of about 483,373 (407)
Detection and toxicity evaluation of pyrrolizidine alkaloids in medicinal plants Gynura bicolor and Gynura divaricata collected from different Chinese locations [PDF]
, 2017 Two edible plants in Southeast Asia, Gynura bicolor and G.divaricata, are not only known to be nutritive but also useful as medicinal herbs. Previous phytochemical investigation of Gynura species showed the presence of hepatotoxic pyrrolizidine alkaloids
Chen, Jian +7 more
core +2 more sources
Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum [PDF]
, 2014 Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf ...
Goossens, Alain +11 more
core +4 more sources
Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects
Molecules, 2019 Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity.
Esteban Rodríguez-Arce +4 more
doaj +1 more source
Network-analysis-guided synthesis of weisaconitine D and liljestrandinine. [PDF]
, 2015 General strategies for the chemical synthesis of organic compounds, especially of architecturally complex natural products, are not easily identified. Here we present a method to establish a strategy for such syntheses, which uses network analysis.
Gallego, GM +8 more
core +2 more sources
MoleculesSeven new alkaloids [1, (±)-2, (±)-3, 4, and 5] and one new natural product (6), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic
Xu Chen +10 more
doaj +1 more source
Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives
Marine Drugs, 2020 Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these ...
Cássio R M Souza +2 more
semanticscholar +1 more source
Fatal heart block from intentional yew tree (Taxus baccata) ingestion: a case report [PDF]
, 2019 © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org ...
Chan, Mark +3 more
core +2 more sources
, 2017 Cephalotaxus alkaloids represent a family of plant secondary metabolites known for 60 years. Significant activity against leukemia in mice was demonstrated for extracts of Cephalotaxus. Cephalotaxine (CET) (1), the major alkaloid of this series was isolated from Cephalotaxus drupacea species by Paudler in 1963.
Pérard-Viret, Joelle +4 more
openaire +3 more sources
Nat. Prod. Rep., 2014 This review focuses on the isolation and synthesis of natural products containing a 1-azabicyclo[3.3.0]octane core (July 2001 to December 2012).
Robertson, J, Stevens, K
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source