Results 131 to 140 of about 253,250 (328)
Advanced Science, EarlyView.Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li +7 more
wiley +1 more source
Orbital: The Electronic Journal of Chemistry, 2010 Selectivity of alkylation at the N1 position in pyrimidines (thymine and uracil) was achieved by the application of N3-benzoyl thymine and N3-benzoyl uracil as substrates, where the N3 atom was temporarily protected, exposing the N1 atom as the ...
Fábio D. P. Soares +3 more
doaj
Advanced Science, EarlyView.A density functional theory (DFT)‐based framework is proposed to predict CO2 capture performance of piperazine derivatives. 2,6‐dimethylpiperazine (26DMPZ) is identified as a promising candidate: CO2‐induced precipitation in water eliminates the need for organic solvents; the low‐solubility, unstable dicarbamate enhances CO2 capture efficiency and ...
Feng Xie +5 more
wiley +1 more source
Advanced Science, EarlyView.Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu +10 more
wiley +1 more source
Copper-catalyzed arylation of alkyl halides with arylaluminum reagents
Beilstein Journal of Organic Chemistry, 2015 We report a Cu-catalyzed coupling between triarylaluminum reagents and alkyl halides to form arylalkanes. The reaction proceeds in the presence of N,N,N’,N’-tetramethyl-o-phenylenediamine (NN-1) as a ligand in combination with CuI as a catalyst.
Bijay Shrestha, Ramesh Giri
doaj +1 more source
Iron catalyzed β-C(sp2)–H alkylation of enamides
, 2021 Sylvain Bertho +6 more
openalex +2 more sources
Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment
Advanced Science, EarlyView.Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr. +20 more
wiley +1 more source
Cymenes. 1. Modern state of processes for producing cymenes
Тонкие химические технологии, 2012 The article analyzes methods for the preparation of cymenes based on using petrochemical raw materials: toluene and propylene/isopropanol. It is concluded that at present advanced technologies for the production of individual cymenes are absent, and the ...
T. N. Nesterova +5 more
doaj
Genome‐Wide Association Analyses Reveal the Genetic Basis of EMS Mutagenesis Efficiency in Rice
Advanced Science, EarlyView.Based on large‐scale screening of 420 rice accessions, GWAS identified the Rc locus as a key regulator of EMS mutagenesis efficiency. Functional Rc alleles enhance both seed survival and genome‐wide mutation frequency by boosting antioxidant enzyme activities (CAT, SOD, POD) and reducing oxidative damage.
Peizhou Xu +9 more
wiley +1 more source